[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637477":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":12,"locations":18,"responsibleParty":30,"collaborators":7,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":7,"enrollmentInfo":44,"targetDuration":7,"studyType":47,"phases":7,"briefSummary":48,"conditions":49,"keywords":7,"overallStatus":52,"whyStopped":7,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"periodontal charting for the diagnosis of periodontitis","No additional interventions",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Professor Rotundo Roberto","CONTACT","0201751500","rotundo.roberto@hsr.it",[19],{"facility":5,"status":7,"city":20,"state":7,"zip":21,"country":22,"countryCode":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":7},"Milan","20132","Italy","IT",{"type":25,"coordinates":26},"Point",[27,28],12.59836,42.78235,{"lat":28,"lon":27},{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Rotundo Roberto","Associate Professor","100637477","periodontal-disease-in-patients-with-lynch-syndrome-100637477",false,"NCT07600710","Periodontal Disease in Patients With Lynch Syndrome","Periodontal Disease in Patients With Lynch Syndrome: a Retrospective Observational, Monocentric Case-control Study","SMILy_25","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. All sexes eligible\n3. Established diagnosis of LS performed as part of clinical practice, with a germline pathogenic\u002Flikely pathogenic variant in one of the following genes: MLH1, MSH2, MSH6, PMS2, and EpCAM\n4. LS subjects undergoing surveillance gastrointestinal endoscopy according to clinical practice and international guidelines.\n5. Subjects underwent dental and periodontal examination\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years;\n2. Absence of sufficient periodontal clinical or radiographic data to establish a periodontal diagnosis;\n3. Subjects affected by systemic, autoimmune, chronic inflammatory, neurological, or severe psychiatric disorders, or by any other clinical condition that may interfere with study participation or data interpretation\n4. Subjects with systemic conditions known to strongly affect periodontal status (e.g. uncontrolled diabetes, autoimmune inflammatory diseases, ongoing cancer therapy) were excluded to reduce major confounding factors that could independently alter periodontal outcomes.","ALL","18 Years",{"count":45,"type":46},25,"ESTIMATED","OBSERVATIONAL","The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a \"chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus\"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.",[50,51],"Lynch Syndrome","Periodontal Disease","NOT_YET_RECRUITING","2026-05-18",{"date":55,"type":56},"2026-05-22","ACTUAL",{"date":58,"type":46},"2026-06-01",{"date":60,"type":46},"2026-07-31",{"name":32,"class":6},1]