[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554368":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":42,"locations":48,"responsibleParty":66,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":92,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL","In the experimental group, subjects will undergo periodontal initial treatment under local anesthesia combined with glucocorticoid local blockade therapy (such as triamcinolone acetonide injection), local use of triamcinolone acetonide ointment, and 1% sodium bicarbonate rinse (avoiding systemic use during visits) after baseline examination, while receiving the following professional oral hygiene guidance:\n\nInstructions and demonstrations for using manual toothbrushes Instructions and demonstrations for using dental floss or interdental brushes A periodontist with rich clinical experience will perform periodontal initial treatment under local anesthesia.",[13,14,15],"Other: Periodontal initial treatment under local anesthesia","Drug: Glucocorticoid Therapy","Behavioral: oral hygiene instruction",{"label":17,"type":18,"description":19,"interventionNames":20},"Control group","ACTIVE_COMPARATOR","In the control group, participants will undergo routine glucocorticoid local blockade therapy (such as triamcinolone acetonide injection), local administration of triamcinolone acetonide ointment, and 1% sodium bicarbonate rinse (avoiding systemic medication during visits) after baseline examination, while receiving the following professional oral hygiene guidance:\n\nInstructions and demonstrations for using manual toothbrushes Instructions and demonstrations for using dental floss or interdental brushes Based on ethical considerations, all participants will receive full mouth periodontal initial treatment at the end of the trial.",[14,15],[22,27,32],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"Periodontal initial treatment under local anesthesia","Removal of plaque retention factors, supragingival scaling and subgingival scraping under local anesthesia with articaine (combined with manual and ultrasound methods), and polishing",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Glucocorticoid Therapy","Local blockade therapy with Betamethasone Sodium Phosphate Injection (containing 1.4mg Betamethasone equivalent), local use of 1% Triamcinolone Acetate Ointment, and rinsing with 1% Sodium Bicarbonate (avoiding systemic use during visits)",[17,9],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":26},"BEHAVIORAL","oral hygiene instruction","Instructions and demonstrations for using manual toothbrushes Instructions and demonstrations for using dental floss or interdental brushes",[17,9],[38],{"name":39,"affiliation":40,"role":41},"Linjun Shi, Doctor","Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","PRINCIPAL_INVESTIGATOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":26,"email":47},"Hong Zhen, Doctor","CONTACT","+86-021-53315576","shjyiec@163.com",[49],{"facility":50,"status":26,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Shanghai Ninth People's Hospital","Shanghai","Shanghai Municipality","200011","China","CN",{"type":57,"coordinates":58},"Point",[59,60],121.45806,31.22222,{"lat":60,"lon":59},[63],{"name":39,"role":45,"phone":64,"phoneExt":26,"email":65},"+86 18149733306","drshilinjun@126.com",{"type":67,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100554368","periodontal-initial-treatment-combined-with-glucocorticoid-therapy-for-erosive-oral-lichen-planus-100554368",false,"NCT06498180","Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus","A Randomized Self-control Study of Periodontal Initial Treatment Under Local Anesthesia Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus","Inclusion Criteria:\n\n* Existence of erosive oral lichen planus that lasts for more than 2 months\n* Erosive lesions are located in the buccal mucosa and gingival buccal sulcus of the bilateral mandibular posterior teeth area\n* The erosive lesions are mild to moderate (single or multiple small area erosions; 3mm ≤ longest diameter ≤ 10mm; 9mm2 ≤ total area of erosions ≤ 100mm2), and the degree of erosion on both sides is similar (the difference in the size of erosion on both sides does not exceed ± 25%)\n* The plaque index in the area of erosive lesions is ≥ 3; Dental calculus index ≥ 2; Gingival index ≥ 2;\n* Accompanied by stage II-IV extensive periodontitis\n\nExclusion Criteria:\n\n* Pregnant women, lactating women, or women planning to conceive during the trial period\n* Patients with coagulation dysfunction or other uncontrolled systemic diseases who cannot undergo periodontal treatment\n* Has undergone basic periodontal treatment within the past 6 months\n* Individuals with a history of allergy to local anesthetic drugs such as articaine\n* Individuals with contraindications to glucocorticoids\n* Patients with lesion area erosion caused by trauma or chemical stimulation\n* Patients with mental disorders who are difficult to cooperate with treatment","ALL","18 Years","75 Years",{"count":79,"type":80},29,"ESTIMATED","INTERVENTIONAL",[83],"NA","The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for erosive oral lichen planus. It will also understand the safety of this treatment regimen.\n\nThis study is a single-center, parallel-group, randomized self-controlled trial. The researchers will compare the treatment of periodontal initial therapy combined with glucocorticoid therapy under local anesthesia with traditional glucocorticoid therapy to see if the treatment of periodontal initial therapy combined with glucocorticoid therapy under local anesthesia promotes the healing of erosive oral lichen planus.\n\nParticipants will:\n\nOne side received periodontal initial treatment combined with glucocorticoid under local anesthesia, while the other side received traditional glucocorticoid therapy Clinical examination at 2, 4, 8, and 12 weeks after treatment Note down the size of their erosion lesion area and periodontal clinical parameters",[86,87],"Oral Lichen Planus","Periodontal Diseases",[89,90,91],"Periodontal initial therapy","Erosive oral lichen planus","Local anesthesia","NOT_YET_RECRUITING","2024-07-11",{"date":95,"type":96},"2024-07-12","ACTUAL",{"date":98,"type":80},"2024-12-31",{"date":100,"type":80},"2028-03-31",{"name":5,"class":6},1]