[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570223":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":29,"collaborators":7,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":36,"acronym":7,"eligibilityCriteria":37,"healthyVolunteers":34,"sex":38,"minAge":7,"maxAge":7,"enrollmentInfo":39,"targetDuration":7,"studyType":42,"phases":7,"briefSummary":43,"conditions":44,"keywords":49,"overallStatus":11,"whyStopped":7,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":61},{"fullName":5,"class":6},"First Affiliated Hospital of Kunming Medical University","OTHER",null,[9],{"facility":10,"status":11,"city":12,"state":13,"zip":14,"country":15,"countryCode":16,"cosmosGeoPoint":17,"geoPoint":22,"contacts":23},"The first affiliated hospital of KUNMING medical university","RECRUITING","Kunming","Yunnan","650032","China","CN",{"type":18,"coordinates":19},"Point",[20,21],102.71833,25.03889,{"lat":21,"lon":20},[24],{"name":25,"role":26,"phone":27,"phoneExt":7,"email":28},"Haixia Jiang","CONTACT","+86-18875200060","18875200060@163.com",{"type":30,"investigatorFullName":25,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Clinical Professor of The first affiliated hospital of KUNMING medical university","100570223","perioperative-il-33-is-associated-with-the-early-stage-of-postoperative-neurocognitive-dysfunction-after-major-abdominal-surgery-100570223",false,"NCT06704451","Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery","Inclusion Criteria:Patients were included if they had an American Society of Anesthesiologists status of Ⅱto Ⅳ and requiring a Gastrointestinal or a Hepatic surgery .\n\nExclusion Criteria:\n\n1. history of mental diseases;\n2. patients with current Neurological disease;\n3. patients who refused or were unable to finish the neurocognitive evaluation;\n4. preoperative Mini-Mental Stare Examination (MMSE) less than required score (illiteracy \\\u003C17; primary school \\\u003C 20; middle school and higher \\\u003C 24).","ALL",{"count":40,"type":41},150,"ESTIMATED","OBSERVATIONAL","Perioperative neurocognitive dysfunction(PND) are common complications of major surgery among patients, could be a long-term disease, which sometimes lasts for several years, and it is meaningful to find a biomarker of PND at the early stage.As far as we know, the relationship between IL-33 and PND is not clear yet in the gastrointestinal and hepatic area. Thus, the investigators designed this study to find out the association between IL-33 and occurrence of PND, and determine whether IL-33 could be a biomarker of the early stage of PND.Study population included 150 subjects. Neuropsychological questionnaire were administrated one day before surgery and three days after surgery. And the end of the operation peripheral venous blood was sampled to measure IL-33 inflammatory protein expression in peripheral blood monocytes. Analyze the data and draw conclusions.",[45,46,47,48],"Postoperative Neurocognitive Dysfunction","Cognitive Dysfunction","Postoperative Complications","Neuropsychological Tests",[50,45,47,51],"Interleukin-33","Inflammasomes","2024-11-24",{"date":54,"type":55},"2024-11-26","ACTUAL",{"date":57,"type":55},"2014-08-18",{"date":59,"type":41},"2025-12-30",{"name":5,"class":6},1]