[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513925":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":38,"centralContacts":42,"locations":48,"responsibleParty":76,"collaborators":78,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":92,"sex":98,"minAge":99,"maxAge":27,"enrollmentInfo":100,"targetDuration":27,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":51,"whyStopped":27,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (immunonutrition and oral chlorhexidine decontamination, IN&CD)","EXPERIMENTAL","Patients in this group will receive immunonutrition supplementation from the day of allocation at the preoperative anesthesia clinic until the day before surgery (usually 1-3 weeks), which is oral intake of ORAL IMPACT™ 2 servings per day. Patients will also receive oral chlorhexidine decontamination using 0.12% chlorhexidine oral rinse twice daily from the day before surgery until postoperative day 3.",[13,14],"Dietary Supplement: immunonutrition supplement of ORAL IMPACT™","Other: oral chlorhexidine decontamination",{"label":16,"type":10,"description":17,"interventionNames":18},"Group B (immunonutrition and routine oral care, IN&RC)","Patients in this group will receive immunonutrition supplementation from the day of allocation at the preoperative anesthesia clinic until the day before surgery (usually 1-3 weeks), which is oral intake of ORAL IMPACT™ 2 servings per day. For oral health care, they will receive routine oral care which is routine toothbrushing twice daily.",[13],{"label":20,"type":10,"description":21,"interventionNames":22},"Group C (routine nutrition advice and oral chlorhexidine decontamination, RN&CD)","Patients in this group will be advised to follow a standard nutrition advice with a total intake of 30kcal\u002Fkg\u002Fd and protein intake of 1.2g\u002Fkg\u002Fd. They will also receive oral chlorhexidine decontamination using 0.12% chlorhexidine oral rinse twice daily from the day before surgery until postoperative day 3.",[14],{"label":24,"type":25,"description":26,"interventionNames":27},"Group D (routine nutrition advice and routine oral care, RN&RC)","NO_INTERVENTION","Patients in this group will be advised to follow a standard nutrition advice with a total intake of 30kcal\u002Fkg\u002Fd and protein intake of 1.2g\u002Fkg\u002Fd. They will also receive routine oral care which is routine toothbrushing twice daily.",null,[29,34],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":27},"DIETARY_SUPPLEMENT","immunonutrition supplement of ORAL IMPACT™","For intervention group, patients will take immunonutrition supplement after recruitment until the day before surgery.",[9,16],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":27},"oral chlorhexidine decontamination","For intervention group, patients will use 0.12% chlorhexidine for oral rinse twice daily from the day before surgery until 3 days after surgery.",[9,20],[39],{"name":40,"affiliation":5,"role":41},"Yuguang Huang, Dr","PRINCIPAL_INVESTIGATOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":27,"email":47},"Lu Che, Dr","CONTACT","69152020","tracymaobao@126.com",[49,66],{"facility":50,"status":51,"city":52,"state":53,"zip":27,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"The Second Hospital of Hebei Medical University","RECRUITING","Shijiazhuang","Hebei","China","CN",{"type":57,"coordinates":58},"Point",[59,60],114.47861,38.04139,{"lat":60,"lon":59},[63],{"name":64,"role":45,"phone":27,"phoneExt":27,"email":65},"Chaolei Liu","verna521@163.com",{"facility":5,"status":51,"city":67,"state":27,"zip":27,"country":54,"countryCode":55,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Beijing",{"type":57,"coordinates":69},[70,71],116.39723,39.9075,{"lat":71,"lon":70},[74],{"name":75,"role":45,"phone":27,"phoneExt":27,"email":47},"Lu Che, M.D",{"type":77,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[79,81,82,84,86,88],{"name":80,"class":6},"Fujian Provincial Hospital",{"name":50,"class":6},{"name":83,"class":6},"Shenzhen Nanshan District Shekou People's Hospital",{"name":85,"class":6},"Ningbo No.2 Hospital",{"name":87,"class":6},"Peking University International Hospital",{"name":89,"class":6},"Guizhou Provincial People's Hospital","100513925","perioperative-oral-decontamination-and-immunonutrition-point-in-elderly-100513925",false,"NCT05971810","Perioperative Oral Decontamination and ImmunoNuTrition (POINT) in Elderly","Perioperative Oral Decontamination and ImmunoNuTrition (POINT) on Postoperative Pulmonary Complications in Elderly: a Multicenter Randomized Controlled Trial","POINT","Inclusion Criteria:\n\n1. age≥65 years;\n2. undergoing major non-cardiac surgery;\n3. scheduled for general anesthesia and endotracheal intubation;\n4. American Society of Anesthesiologists (ASA) physical status classification I-IV;\n5. with intermediate to high risk of respiratory complications assessed by Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score;\n6. informed consent obtained.\n\nExclusion Criteria:\n\n1. emergency surgery;\n2. preoperative pneumonia;\n3. allergic to chlorhexidine;\n4. severe hepatic\u002Frenal dysfunction, incapable of oral feeding, with autoimmune diseases, taking immunosuppressant or immunoregulation medications, or with other contraindication to immunonutrition supplementation;\n5. expected intervention of immunonutrition\\\u003C3 days.","ALL","65 Years",{"count":101,"type":102},592,"ESTIMATED","INTERVENTIONAL",[105],"NA","The goal of this multicenter randomized controlled trial is to explore the efficacy of perioperative oral decontamination and immunonutrition supplement to prevent postoperative pulmonary complications in elderly patients(≥65 years) receiving elective non-cardiac operations. Participants will be either given immunonutrition supplement versus routine nutrition advice, and oral chlorhexidine decontamination versus routine oral care randomly. The two interventions will be compared with control groups separately regarding postoperative pulmonary complications and other outcomes.",[108,109],"Postoperative Complications","Pulmonary Complication",[111,112,113],"immunonutrition","oral decontamination","postoperative pulmonary complications","2025-01-25",{"date":116,"type":117},"2025-01-28","ACTUAL",{"date":119,"type":117},"2023-08-23",{"date":121,"type":102},"2025-09-01",{"name":5,"class":6},2]