[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628411":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":24,"responsibleParty":43,"collaborators":24,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":24,"eligibilityCriteria":51,"healthyVolunteers":48,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":24,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":24,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":24},{"fullName":5,"class":6},"Fudan University","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Conventional Ventilation Group","In this group, no PEEP is applied during anesthesia induction; conventional PEEP of 5 cmH₂O is used intraoperatively; and conventional face-mask oxygen therapy (at an oxygen flow rate of 5 L\u002Fmin) is administered after tracheal extubation.",[12],"Other: Conventional Ventilation",{"label":14,"type":15,"description":16,"interventionNames":17},"POP Group","EXPERIMENTAL","Perioperative Prophylactic Positive Airway Pressure Group. In this group, a PEEP of 10 cmH₂O is applied during general anesthesia induction; EIT-guided individualized PEEP is utilized during surgery; and following tracheal extubation, high-flow nasal cannula (HFNC) oxygen therapy (with an FiO₂ of 40%) is administered to maintain positive end-expiratory pressure.",[18],"Other: Perioperative positive pressure ventilation",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Conventional Ventilation","No PEEP is applied during anesthesia induction; conventional PEEP of 5 cmH₂O is used during surgery; and after tracheal extubation, conventional face mask oxygen therapy (at an oxygen flow rate of 5 L\u002Fmin) is administered.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Perioperative positive pressure ventilation","A PEEP of 10 cmH₂O is applied during general anesthesia induction; EIT-guided individualized PEEP is utilized during surgery; and following tracheal extubation, high-flow nasal cannula (HFNC) oxygen therapy (with an FiO₂ of 40%) is administered to maintain positive end-expiratory pressure.",[14],[30],{"name":31,"affiliation":32,"role":33},"Jun Zhang","Fudan University Shanghai Cancer Centre","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Jun Zhang Fudan University, Professor","CONTACT","13817153025","snapzhang@aliyun.com",{"name":41,"role":37,"phone":24,"phoneExt":24,"email":42},"Li Yang","liyangmagic@sina.com",{"type":44,"investigatorFullName":31,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Professor","100628411","perioperative-prophylactic-positive-pressure-ventilation-reduces-postoperative-pulmonary-complications-100628411",false,"NCT07461285","Perioperative Prophylactic Positive Pressure Ventilation Reduces Postoperative Pulmonary Complications.","Inclusion Criteria:\n\n* Patients who have signed the informed consent form and are willing to comply with the study protocol;\n* Age ≥ 18 years and ≤ 90 years;\n* ASA physical status classification I to III;\n* Scheduled for major elective abdominal surgery;\n* Undergoing general anesthesia with endotracheal intubation;\n* ARISCAT (Assessement of Respiratory Risk in Surgical Patients in Catalonia) score ≥ 45;\n* Anticipated surgery duration ≥ 2 hours.\n\nExclusion Criteria:\n\n* Untreated ischemic heart disease; severe cardiovascular or cerebrovascular disease;\n* Severe asthma, pulmonary bullae\u002Fbullous lung disease, pneumothorax, bronchopleural fistula, etc.;\n* Severe underlying hepatic or renal disease;\n* Age \\\u003C 18 years or \\> 90 years;\n* Refusal to participate in the clinical study.","ALL","18 Years","90 Years",{"count":56,"type":57},206,"ESTIMATED","INTERVENTIONAL",[60],"NA","The incidence of postoperative pulmonary complications (PPCs) ranges from 5% to 33%. PPCs significantly prolong hospital stay, increase the economic burden, and are associated with postoperative mortality at 30 days and 1 year. The occurrence of PPCs is associated with multiple perioperative factors. A multimodal approach may provide better prevention against PPCs. We hypothesize that perioperative prophylactic positive pressure ventilation can reduce the incidence of PPCs in patients undergoing high-risk abdominal surgery.",[63],"Postoperative Pulmonary Complications (PPCs)",[65,66,67],"Postoperative pulmonary complications","positive pressure ventilation","abdominal surgery","NOT_YET_RECRUITING","2026-03-07",{"date":71,"type":72},"2026-03-10","ACTUAL",{"date":74,"type":57},"2026-03-20",{"date":76,"type":57},"2026-09-30",{"name":31,"class":6}]