[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552761":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":20,"responsibleParty":36,"collaborators":7,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":7,"eligibilityCriteria":43,"healthyVolunteers":40,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":7,"studyType":50,"phases":7,"briefSummary":51,"conditions":52,"keywords":7,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},{"fullName":5,"class":6},"St. Jude Children's Research Hospital","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Andrew Heitzer, Phd","PRINCIPAL_INVESTIGATOR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Andrew Heitzer, PhD","CONTACT","888-226-4343","referralinfo@stjude.org",{"name":19,"role":15,"phone":16,"phoneExt":7,"email":17},"Stephanie Guthrie, RN, BSN",[21],{"facility":5,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"RECRUITING","Memphis","Tennessee","38105","United States","US",{"type":29,"coordinates":30},"Point",[31,32],-90.04898,35.14953,{"lat":32,"lon":31},[35],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},{"type":37,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100552761","peripheral-arterial-tonometry-and-neurocognition-in-sickle-cell-disease-100552761",false,"NCT06477289","Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease","Inclusion Criteria:\n\n* Diagnosed with sickle cell disease of any genotype\n* Participant in the Sickle Cell Clinical Research and Intervention Program\n* Between 12-25 years of age at the time of enrollment\n* English is the primary language\n* Access to an electronic device with WiFi\n\nExclusion Criteria:\n\n* History of an intellectual disability\n* History of a traumatic brain injury or seizure disorder\n* History of a stroke\n* Undergoing potential curative treatment for SCD (stem cell transplant or gene therapy)\n* Currently prescribed an intervention for a sleep disorder\n* Inability or unwillingness of research participant or legal guardian\u002Frepresentative to give written informed consent.","ALL","12 Years","25 Years",{"count":48,"type":49},65,"ESTIMATED","OBSERVATIONAL","This study will examine sleep disordered breathing and sleep quality in participants (ages 12-25) diagnosed with sickle cell disease of any genotype. We will utilize remote peripheral arterial tonometry (PAT) and questionnaires to evaluate difficulties with sleep. PAT assessments will occur remotely in the homes of participants.\n\nNeurocognitive, behavioral, and neuroimaging evaluations will occur on the same day as a routine clinic visit.\n\nPrimary Objective:\n\nEvaluate the relationship between nocturnal oxyhemoglobin saturation (SpO2) and neurocognitive functioning (working memory and verbal comprehension) in individuals (ages 12-25) diagnosed with sickle cell disease controlling for age, genotype, and social vulnerability.\n\nSecondary Objective:\n\nAssess differences in white matter integrity, silent cerebral infarcts, neuroinflammation, and functional connectivity among individuals (ages 12-25) diagnosed with sickle cell disease with and without sleep disordered breathing after controlling for age.\n\nAssess differences in self- and caregiver-reported mood and pain severity among individuals (ages 12-25) diagnosed with sickle cell disease with and without sleep disordered breathing after controlling for age.\n\nExploratory Objectives:\n\nExplore the relationship between nocturnal oxyhemoglobin saturation (SpO2) and neurocognitive functioning (attention, processing speed, verbal memory, visual memory, motor dexterity) in individuals (ages 12-25) diagnosed with sickle cell disease controlling for age, genotype, and social vulnerability.\n\nAssess the feasibility of an optical imaging tool (Speckle Contrast Optical Spectroscopy - Open-Motion 3.0) to measure cerebral blood flow and blood volume in patients diagnosed with sickle cell disease (ages 12-25).\n\nAssess the concordance between measurement of cerebral blood flow and volume using speckle contrast optical spectroscopy and arterial spin labeling brain MRI.",[53],"Sickle Cell Disease","2026-06-25",{"date":56,"type":57},"2026-06-29","ACTUAL",{"date":59,"type":57},"2024-09-16",{"date":61,"type":49},"2028-06",{"name":5,"class":6},1]