[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640087":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":18,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":7,"eligibilityCriteria":32,"healthyVolunteers":28,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":7,"studyType":39,"phases":7,"briefSummary":40,"conditions":41,"keywords":44,"overallStatus":50,"whyStopped":7,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":7},{"fullName":5,"class":6},"Women's Hospital School Of Medicine Zhejiang University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Junfen Xu","CONTACT","+86 13567147767","xjfzu@zju.edu.cn",{"type":15,"investigatorFullName":16,"investigatorTitle":17,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Wang Hui","Professor",[19,21,23],{"name":20,"class":6},"Jiaxing Maternity and Child Health Care Hospital",{"name":22,"class":6},"Ningbo Women & Children's Hospital",{"name":24,"class":25},"Zhejiang PuLuoTing Health Technology Co., Ltd.","UNKNOWN","100640087","peripheral-blood-cytof-immune-model-for-cervical-lesion-detection-in-hpv1618-women-100640087",false,"NCT07606677","Peripheral Blood CyTOF Immune Model for Cervical Lesion Detection in HPV16\u002F18+ Women","Mass Cytometry-based Peripheral Blood Immune Model for Accurate Detection of Cervical Lesions in HPV16\u002F18-positive Women: a Multicenter Study","Inclusion Criteria:\n\n* Availability of cervical cytology results\n* Consent to colposcopy and cervical biopsy\n* Signed informed consent\n\nExclusion Criteria:\n\n* Confirmed diagnosis of CIN2 or worse\n* Prior cervical ablation, cervical conization, chemoradiotherapy, or immunotherapy\n* Other malignancy within the past 2 years not in complete remission\n* Presence of other systemic immune disease or active infection\n* Pregnancy or lactation\n* Inability to comply with follow-up and examinations\n* Inability to comply with study procedures, restrictions, and requirements, as determined by the investigator","FEMALE","25 Years","65 Years",{"count":37,"type":38},1465,"ESTIMATED","OBSERVATIONAL","This prospective, multicenter cohort study will recruit eligible HPV16\u002F18-positive women from three tertiary hospitals in China. Peripheral blood samples and clinical data (cytology, HPV genotyping, colposcopy-directed biopsy) will be collected, followed by standardized mass cytometry (CyTOF) to develop and evaluate an immune model across cervical lesion grades.",[42,43],"CIN 2\u002F3","Cervical Cancer (Early Detection)",[45,46,47,48,49],"cervical cancer","Cervical Intraepithelial Neoplasia","HPV16\u002F18","Mass cytometry","Immune model","NOT_YET_RECRUITING","2026-05-18",{"date":53,"type":54},"2026-05-26","ACTUAL",{"date":56,"type":38},"2026-05-15",{"date":58,"type":38},"2028-03-31",{"name":5,"class":6}]