[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623012":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":30,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"SEPTIC PATIENTS",null,"This cohort includes adult participants admitted to the intensive care unit with sepsis or septic shock, defined according to Sepsis-3 criteria with a Sequential Organ Failure Assessment (SOFA) score of 2 or higher at inclusion.\n\nParticipants will receive standard ICU care according to local protocols. Peripheral perfusion will be assessed using capillary refill time and end-tidal carbon dioxide measurements at predefined time points (baseline, 6 hours, and 24 hours). In addition, paired arterial and venous blood gas samples will be collected at the same time points to evaluate markers of tissue perfusion, including lactate levels and the veno-arterial carbon dioxide difference.\n\nNo experimental treatments or protocol-driven changes to clinical management will be introduced.",[13],"Other: PERIPHERAL PERFUSION EVALUATION",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"PERIPHERAL PERFUSION EVALUATION","This intervention consists of a predefined, multimodal peripheral perfusion assessment combining bedside clinical evaluation and blood gas analysis. Capillary refill time is measured at standardized time points, together with concurrent end-tidal carbon dioxide recording. Paired arterial and venous blood gas samples are obtained at the same time points to calculate the veno-arterial carbon dioxide difference and assess lactate levels. The intervention is limited to repeated physiological measurements during the first 24 hours of ICU admission and does not include any therapeutic intervention or protocol-driven change in clinical management",[9],[20],{"name":21,"affiliation":22,"role":23},"Alexandra Elena Lazăr","George Emil Palade University of Medicine, Pharmacy, Science and Technology from Tirgu Mures, Romania","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Alexandra Elena Lazăr, Consultant, Assoc prof","CONTACT","+40737067900","alexandralazar7@gmail.com",[31],{"facility":32,"status":10,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Emergebcy Clinical County Hospital - Intensive Care Clinic","Târgu Mureş","Mureș County","540136","Romania","RO",{"type":39,"coordinates":40},"Point",[41,42],24.55747,46.54245,{"lat":42,"lon":41},[45],{"name":21,"role":27,"phone":46,"phoneExt":10,"email":29},"0737067900",{"type":48,"investigatorFullName":21,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Associate prof","100623012","peripheral-perfusion-and-outcomes-in-icu-patients-with-sepsis-100623012",false,"NCT07391098","Peripheral Perfusion and Outcomes in ICU Patients With Sepsis","Peripheral Perfusion and Outcomes in ICU Patients With Sepsis (PERFUSE-ICU)","PERFUSE-ICU","Inclusion Criteria:\n\n* adults aged 18 years or older\n* admission to the intensive care unit\n* sepsis or septic shock, defined according to Sepsis-3 criteria\n* SOFA score ≥ 2 at inclusion\n* presence of an arterial line and a central venous catheter suitable for blood sampling\n* possibility to perform peripheral perfusion assessment (CRT) at predefined time points\n\nExclusion Criteria:\n\n* age under 18 years\n* pregnancy\n* expected ICU stay less than 24 hours\n* limitations of therapy at ICU admission (e.g., DNR or comfort-only care)\n* improper central venous catheter position (catheter tip not located in the superior vena cava)\n* absence of arterial or central venous access required for paired blood gas sampling\n* refusal of consent, when applicable according to local ethics requirements","ALL","18 Years",{"count":61,"type":62},80,"ESTIMATED","OBSERVATIONAL","People with sepsis who are treated in the intensive care unit (ICU) often have impaired blood flow to the skin and other tissues. These alterations in tissue perfusion may be associated with disease severity and clinical outcomes.\n\nThe aim of this study is to see whether simple signs of blood flow to the skin, such as capillary refill time and blood test measurements, are linked to outcomes in people with sepsis treated in the ICU.\n\nAdults with sepsis who are admitted to the ICU will be invited to take part. Researchers will collect routine clinical data and blood test results during the first day of ICU treatment. No extra procedures or treatments will be performed as part of the study.\n\nThe results of this study may improve understanding of early signs of impaired circulation in sepsis and their relation with recovery and survival.",[66,67],"SEPSIS","Septic Patients",[69,70,71,72,73,74,75],"Peripheral perfusion","Capillary refill time","Veno-arterial carbon dioxide difference","Sepsis outcomes","Tissue hypoperfusion","Intensive care unit","Veno-arterial carbon dioxide difference ΔCO₂ gap","NOT_YET_RECRUITING","2026-02-05",{"date":79,"type":80},"2026-02-09","ACTUAL",{"date":82,"type":62},"2026-02-02",{"date":84,"type":62},"2026-09-30",{"name":21,"class":6},1]