[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596594":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"European Institute of Oncology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prostate patients",null,"prostate patients undergoing RT",[13],"Other: prostate patient",{"label":15,"type":10,"description":16,"interventionNames":17},"breast patients","breast patients undergoing RT",[18],"Other: breast patients",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"prostate patient","patients with prostate cancer treated with RT at IEO",[9],{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":10},"patients with breast cancer treated with RT at IEO",[15],[28],{"name":29,"affiliation":5,"role":30},"Giulia Marvaso","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Giulia Marvaso, MD","CONTACT","+390294372696","giulia.marvaso@ieo.it",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":41,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Milan","Italy","20141","IT",{"type":45,"coordinates":46},"Point",[47,48],9.18951,45.46427,{"lat":48,"lon":47},[51],{"name":29,"role":34,"phone":35,"phoneExt":10,"email":36},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100596594","personalization-of-external-beam-radiation-therapy-in-localised-tumours-100596594",false,"NCT07047495","Personalization of External Beam Radiation Therapy in Localised Tumours","MINIONS - Patient-specific Microstructural and radIobiological Model for persoNalised External Beam radiatION Therapy in Localised tumourS","MINIONS","Inclusion criteria for prostate patients:\n\n* Unifocal infiltrating ductal breast carcinoma, non-special histotype\n* clinical stage T1-T2,N0\n* No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent.\n* Patients aged \\>18 years\n* Good general condition (ECOG 0-2)\n* Expected active treatment (crioablation or surgery or radiotherapy ).\n\nExclusion Criteria:\n\n* Exclusion criteria for prostate patients:\n\n  * Nodule involvement and metastasis (cN1 and\u002For cM1)\n  * Concomitant inflammation of the intestine\n  * Significant systemic diseases or ongoing oral anticoagulant therapy\n  * Non-compliance of dose constraints in the treatment plan\n  * Previous invasive cancer, unless the patient has had no disease for at least 3 years\n  * Mental disorders that cannot ensure valid informed consent\n\nExclusion criteria for breast patients:\n\n* Histology other than non-special histotype and non-epithelial tumors (sarcoma, lymphoma)\n* Male sex\n* High-risk mutation carrier patients\n* Bilateral breast cancer\n* synchronous distant metastases\n* Neoadjuvant therapy\n* autoimmune connective tissue diseases\n* previous radiotherapy to the chest\n* Mental disorders that cannot ensure valid informed consent\n* No previous thoracic radiotherapy","ALL","18 Years",{"count":65,"type":66},35,"ESTIMATED","OBSERVATIONAL","The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT).\n\nWithin the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples\u002Forganoids will be irradiated with RT for biological validation.",[70,71],"Breast Adenocarcinoma","Prostate Cancer (Adenocarcinoma)","2025-06-24",{"date":74,"type":75},"2025-07-02","ACTUAL",{"date":77,"type":66},"2025-07",{"date":79,"type":66},"2030-07",{"name":5,"class":6},1]