[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053544":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":41,"responsibleParty":69,"collaborators":71,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":34,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":111,"whyStopped":34,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Barcelonabeta Brain Research Center, Pasqual Maragall Foundation","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Participants in the control arm will receive general recommendations on dementia risk reduction at the beginning of the study, reflecting standard preventive advice.\n\nThey will have access to a mobile application providing information on dementia risk factors; however, the application will not include personalized feedback or interactive intervention components.\n\nParticipants will also be provided with a wearable fitness tracker to support monitoring of physical activity and sleep.",[13],"Behavioral: Lifestyle Recommendations and Counseling",{"label":15,"type":16,"description":17,"interventionNames":18},"Personalized intervention","EXPERIMENTAL","Participants in the experimental arm will receive a 6-month personalized, multimodal intervention tailored to their individual dementia risk profile.\n\nThe intervention includes components targeting key domains of brain health, including nutrition, physical activity, cognitive training, and psychoeducation, with the intensity and combination of components adapted according to risk level.\n\nParticipants will have access to a mobile application providing personalized feedback on lifestyle behaviors and interactive support to promote adherence to the intervention.\n\nParticipants will also be provided with a wearable fitness tracker to support monitoring of physical activity and sleep.",[19],"Behavioral: Multimodal Lifestyle Intervention",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Multimodal Lifestyle Intervention","The intervention is a 6-month personalized, multimodal dementia risk reduction program based on individual risk stratification. Risk profiles are defined using modifiable and non-modifiable risk factors for Alzheimer's disease, allowing participants to be categorized into low, intermediate, or high-risk groups.\n\nAll participants in the intervention arm will receive structured and personalized counseling delivered through a mobile application.\n\nParticipants in the intermediate- and high-risk groups will additionally be invited to:\n\n(i) complete individual 30-minute cognitive training sessions 2 to 3 times per week via a telematic platform, and (ii) attend monthly psychoeducational group sessions led by a psychologist or trained nurse.\n\nParticipants in the high-risk group will further be invited to attend individual nutrition counseling visits (one session per month) and supervised group-based physical activity sessions in a gymnasium setting (one session per week).",[15],[27],"Non-pharmacological intervention",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Lifestyle Recommendations and Counseling","Standard recommendations on dementia risk reduction will be provided at the beginning of the study, based on general guidance for maintaining brain health. Participants will have access to a mobile application providing educational information on dementia risk factors and healthy lifestyle behaviors. The content will be static and non-interactive, without personalized feedback or tailored recommendations",[9],[33],"General Lifestyle Recommendations",null,[36],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Oriol Grau Rivera","CONTACT","+34 933 26 31 90","ograu@barcelonabeta.org",[42],{"facility":43,"status":34,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Fundació Pasqual Maragall","Barcelona","Catalonia","08005","Spain","ES",{"type":50,"coordinates":51},"Point",[52,53],2.15899,41.38879,{"lat":53,"lon":52},[56,59,62,65,67],{"name":57,"role":38,"phone":39,"phoneExt":34,"email":58},"Anna Soteras Prat","asoteras@barcelonabeta.org",{"name":60,"role":61,"phone":34,"phoneExt":34,"email":34},"Oriol Grau-Rivera, PhD","PRINCIPAL_INVESTIGATOR",{"name":63,"role":64,"phone":34,"phoneExt":34,"email":34},"Ana Fernández-Arcos, PhD","SUB_INVESTIGATOR",{"name":66,"role":64,"phone":34,"phoneExt":34,"email":34},"Natàlia Soldevila Domènech, PhD",{"name":68,"role":64,"phone":34,"phoneExt":34,"email":34},"Andrea Horta-Barba, PhD",{"type":70,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[72,74],{"name":73,"class":6},"Hospital del Mar",{"name":75,"class":76},"Hospital del Mar Research Institute","UNKNOWN","100053544","personalized-brain-health-service-and-dementia-prevention-100053544",false,"NCT07698431","Personalized Brain Health Service and Dementia Prevention","Implementation of a Brain Health Service for Personalized Stratification and Prevention of Dementia Risk: The B-HEALTH Project","B-HEALTH","Inclusion Criteria:\n\n* Participants aged 55 to 85 with subjective cognitive complaints and normal screening test performance at the hospital.\n* Participants must have a minimal educational level for a neuropsychological assessment and a minimal digital literacy for the usage of smartphones, computers and Internet.\n\nExclusion Criteria:\n\n* Objective cognitive impairment.\n* Clinically relevant neurological disorders.\n* Major psychiatric disorders.\n* History of drug\u002Falcohol abuse.\n* Unstable medical conditions that could fully explain cognitive complaints, as determined by the investigator.","ALL","55 Years","85 Years",{"count":89,"type":90},120,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study evaluates the feasibility of implementing a Brain Health Service (BHS) to assess and reduce dementia risk in individuals with Subjective Cognitive Decline (SCD). A total of 120 participants will be recruited from the Cognitive Disorders Unit at Hospital del Mar and randomly assigned to either a personalized intervention group or a control group receiving general prevention advice.\n\nThe study will assess individual biological and lifestyle-related risk factors for dementia and use validated tools to estimate each participant's risk profile. Participants in the intervention group will be offered a structured dementia risk communication and counseling process, with the option to receive or decline their individual risk estimate.\n\nThe intervention consists of a 6-month multimodal program combining digital and in-person strategies tailored to each participant's risk level. These strategies include personalized recommendations to improve lifestyle factors such as diet, physical activity, sleep, social engagement, and cognitive stimulation.\n\nThe main objectives are to evaluate the feasibility of delivering this type of service, including recruitment, adherence, and retention; to assess the psychological impact of communicating dementia risk; and to examine changes in lifestyle behaviors and cognitive outcomes over time compared with a control group.\n\nThis study addresses the need for early, personalized prevention strategies for individuals with SCD and may inform broader implementation of preventive BHS.",[96],"Subjective Cognitive Decline (SCD)",[98,99,100,101,102,103,104,105,106,107,108,109,110],"Dementia prevention","Alzheimer's disease","Subjective cognitive decline (SCD)","Dementia risk communication","Brain Health Service","Personalized prevention plan","Multimodal intervention","Lifestyle factors","Risk stratification","eHealth","ptau-217","mHealth","non-pharmacological","NOT_YET_RECRUITING","2026-07-07",{"date":114,"type":115},"2026-07-13","ACTUAL",{"date":117,"type":90},"2026-09-01",{"date":119,"type":90},"2028-08-01",{"name":5,"class":6},1]