[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614965":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":70,"collaborators":74,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":80,"sex":86,"minAge":87,"maxAge":26,"enrollmentInfo":88,"targetDuration":26,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Modena and Reggio Emilia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RICORDO - Digital Cognitive Rehabilitation","EXPERIMENTAL","Participants assigned to this arm will receive a 5-week personalized cognitive training program using the CE-marked digital therapeutic RICORDO. The intervention consists of 15 tablet-based home sessions (3 per week, 45 minutes each), tailored to the participant's cognitive profile and performance, and remotely monitored by clinicians via a web platform.",[13],"Device: RICORDO",{"label":15,"type":16,"description":17,"interventionNames":18},"S.A.M.B.A. - Lifestyle Education Program","ACTIVE_COMPARATOR","Participants assigned to this arm will follow a 5-week home-based educational program called S.A.M.B.A., which includes 15 sessions (3 per week) using printed and video materials focused on socialization, healthy nutrition, physical activity, psychological well-being, and environmental stimulation. This arm is matched for contact time and format but does not include cognitive training.",[19],"Behavioral: S.A.M.B.A.",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","RICORDO","RICORDO is a CE-marked digital therapeutic for cognitive rehabilitation, delivered via tablet. The program consists of home-based sessions, each lasting approximately 45 minutes. Tasks are automatically adapted based on the participant's baseline cognitive profile and real-time performance. Clinicians remotely monitor adherence and adjust the prescription through a web platform.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","S.A.M.B.A.","S.A.M.B.A. (Socialisation, Alimentazione, Movimento, Benessere psicologico, Ambiente) is a structured, home-based lifestyle education program. Participants receive printed and video materials and complete sessions covering key domains of brain-healthy behavior. This arm is matched in duration and frequency to the experimental arm but includes no cognitive training.",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Giovanna Zamboni, M.D, PhD","CONTACT","+39 059\u002F3962201","giovanna.zamboni@unimore.it",[39,57],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Azienda Ospedaliero Universitaria di Modena","RECRUITING","Modena","Reggio Nell'Emilia (RE)","42122","Italy","IT",{"type":48,"coordinates":49},"Point",[50,51],10.92539,44.64783,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":56,"phoneExt":26,"email":37},"Giovanna Zamboni, MD","00393665306279",{"facility":58,"status":41,"city":59,"state":26,"zip":60,"country":45,"countryCode":46,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"IRCCS \"S. Maria Nascente\"","Milan","20148",{"type":48,"coordinates":62},[63,64],12.59836,42.78235,{"lat":64,"lon":63},[67],{"name":68,"role":35,"phone":69,"phoneExt":26,"email":26},"Francesca Baglio","+39 338 320 5593",{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Giovanna Zamboni","Full Professor of Neurology at the Department of Biomedical, Metabolic and Neural Sciences of the University of Modena and Reggio Emilia",[75],{"name":76,"class":77},"IRCCS Fondazione Don Carlo Gnocchi - ONLUS, Milan","UNKNOWN","100614965","personalized-digital-training-for-cognitive-fitness-in-mild-cognitive-impairment-100614965",false,"NCT07286448","Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment","Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment: the COG-FIT Pragmatic Trial","COG-FIT","Inclusion Criteria:\n\n* Diagnosis of Mild Cognitive Impairment (MCI) based on Petersen (1999) and Winblad (2004), or Subjective Cognitive Decline (SCD) according to Jessen (2014)\n* Mini-Mental State Examination (MMSE) \\> 18 and Clinical Dementia Rating (CDR) ≤ 1\n* Age ≥ 50 years\n* Formal education \\> 3 years\n* Signed informed consent\n* Stable neurotropic pharmacological therapy in the past 3 months (if applicable)\n* Preserved mental capacity (i.e., not under legal guardianship or protective supervision)\n* Preserved ability to understand and produce written and spoken Italian\n\nExclusion Criteria:\n\n* Severe sensory or communication impairments\n* Recent participation (\\\u003C 3 months) in cognitive or rehabilitation programs\n* Failure to provide or withdrawal of informed consent\n* History or evidence of central nervous system disorders that may affect cognition and are unrelated to the study (e.g., major stroke, brain tumors, normal pressure hydrocephalus, traumatic brain injury)\n* History or evidence of major psychiatric disorders\n* Presence of medical conditions that may interfere with cognitive function (e.g., renal or hepatic failure, obstructive sleep apnea, hypothyroidism, vitamin B12 deficiency)","ALL","50 Years",{"count":89,"type":90},100,"ESTIMATED","INTERVENTIONAL",[93],"NA","The goal of this clinical trial is to determine whether a home-based digital cognitive-training program called RICORDO can enhance patients' ability to manage their own health and daily life when they have Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD) and are 50 years of age or older.\n\nThe main questions it aims to answer are:\n\nDoes using RICORDO for five weeks raise the Patient Activation Measure (PAM) score more than an at-home paper-and-video education program called S.A.M.B.A.?\n\nDoes RICORDO also improve cognition, everyday functioning, quality of life and mood compared with S.A.M.B.A.?\n\nResearchers will compare individuals who train with RICORDO to those who follow S.A.M.B.A. to determine which approach is more effective.\n\nParticipants will be randomly assigned to one of the two groups and complete three 45-minute sessions per week at home for five weeks. They will also visit the clinic at the beginning and end of the program to complete questionnaires and take brief thinking tests.",[96,97],"Mild Cognitive Impairment (MCI)","Subjective Cognitive Decline (SCD)",[99,100,101,102,103],"Mild Cognitive Impairment","Digital Therapeutics","Cognitive Rehabilitation","Patient Activation","Home-Based Intervention","2026-04-28",{"date":106,"type":107},"2026-04-29","ACTUAL",{"date":109,"type":107},"2025-11-28",{"date":111,"type":90},"2026-11-30",{"name":72,"class":6},2]