[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468495":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":37,"responsibleParty":107,"collaborators":111,"id":115,"slug":116,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":123,"minAge":124,"maxAge":24,"enrollmentInfo":125,"targetDuration":24,"studyType":128,"phases":129,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":40,"whyStopped":24,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mother undergoing planned Cesarean section","EXPERIMENTAL","Mother subject will have genotyping blood draw performed at the time of controlled delivery (CD). Blood samples and breast milk samples will also be taken during the oxycodone dosing schedule.",[13],"Diagnostic Test: Preoperative Genotyping",{"label":15,"type":10,"description":16,"interventionNames":17},"Infant","Infant subject will have genotyping blood draw performed only at the time of controlled delivery (CD)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Preoperative Genotyping","Genotype based risk prediction and personalized pain management",[15,9],null,[26],{"name":27,"affiliation":5,"role":28},"Senthilkumar Sadhasivam, MD, MPH","PRINCIPAL_INVESTIGATOR",[30,34],{"name":27,"role":31,"phone":32,"phoneExt":24,"email":33},"CONTACT","4126472994","sadhasivams@upmc.edu",{"name":35,"role":31,"phone":24,"phoneExt":24,"email":36},"Dayana Alsamsam, MPH","alsamsamd@upmc.edu",[38,62,81,97],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Riley Children's Hospital- Clinics \u002F Labor and Delivery Unit","RECRUITING","Indianapolis","Indiana","46202","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-86.15804,39.76838,{"lat":50,"lon":49},[53,57,61],{"name":54,"role":31,"phone":55,"phoneExt":24,"email":56},"David M. Haas, MD","317-880-3960","dahaas@iu.edu",{"name":58,"role":31,"phone":59,"phoneExt":24,"email":60},"Jill Wallace, CIP","317-278-2311","jilawall@iu.edu",{"name":54,"role":28,"phone":24,"phoneExt":24,"email":24},{"facility":63,"status":40,"city":64,"state":65,"zip":66,"country":44,"countryCode":45,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Washington University Hospital","St Louis","Missouri","63110",{"type":47,"coordinates":68},[69,70],-90.19789,38.62727,{"lat":70,"lon":69},[73,77],{"name":74,"role":31,"phone":75,"phoneExt":24,"email":76},"Arvind Palanisamy, MD","314-362-2330","arvind.palanisamy@wustl.edu",{"name":78,"role":31,"phone":79,"phoneExt":24,"email":80},"Carissa Minder","314-747-6845","Carissa.minder@wustl.edu",{"facility":82,"status":83,"city":84,"state":85,"zip":86,"country":44,"countryCode":45,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"UPMC Magee Women's Hospital","NOT_YET_RECRUITING","Pittsburgh","Pennsylvania","15213",{"type":47,"coordinates":88},[89,90],-79.99589,40.44062,{"lat":90,"lon":89},[93],{"name":94,"role":31,"phone":95,"phoneExt":24,"email":96},"Katherine Grace Lim, MD","412-641-4260","limkg2@upmc.edu",{"facility":5,"status":40,"city":84,"state":85,"zip":98,"country":44,"countryCode":45,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"15260",{"type":47,"coordinates":100},[89,90],{"lat":90,"lon":89},[103],{"name":104,"role":31,"phone":105,"phoneExt":24,"email":106},"Amy Monroe, MPH","412-623-6382","monroeal@upmc.edu",{"type":108,"investigatorFullName":109,"investigatorTitle":110,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Senthil Sadhasivam","Professor",[112],{"name":113,"class":114},"National Center for Advancing Translational Sciences (NCATS)","NIH","100468495","personalized-perioperative-analgesia-platform-ppap-for-cesarean-section-100468495",false,"NCT05380531","Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section","PPAP C-Section","Inclusion Criteria:\n\nAdult women (\\>18 yr) All races American Society of Anesthesiologists Classification (ASA) physical status: 1 to 3 undergoing elective Cesarean section that are willing to receive in-patient opioids.\n\nExclusion Criteria:\n\n1. Health conditions including uncontrolled diabetes (gestational or pre-existing) or hypertension (pre-eclampsia, eclampsia, or chronic)\n2. Any history of opioid misuse before or during pregnancy-per self-report and clinical notes\n3. Preoperative severe pain and opioid use\u002Fmisuse, allergy to oxycodone\n4. Allergy to oxycodone\n5. Significant neurological disorders, liver and renal diseases",true,"FEMALE","18 Years",{"count":126,"type":127},700,"ESTIMATED","INTERVENTIONAL",[130],"NA","The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants",[133,134],"Cesarean Section Complications","Opioid Use",[136],"Opioid Exposure","2026-04-08",{"date":139,"type":140},"2026-04-14","ACTUAL",{"date":142,"type":140},"2022-12-05",{"date":144,"type":127},"2027-10-30",{"name":109,"class":6},4]