[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620681":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":57,"collaborators":29,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":29,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":43,"whyStopped":29,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Ankara City Hospital Bilkent","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1- Standard Treatment (Group A1)","EXPERIMENTAL","Intervention Name: Standard Care Intervention Type: Other (Behavioral \u002F Educational \u002F Non-drug) Description: Limitation of overused acute headache medications, lifestyle advice (nutrition, hydration, activity, sleep), and continuation of preventive medications. Participants who respond at 1 month continue standard care.",[13],"Other: Standard care",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2: Primary GONPRF (Group B)","Intervention Name: Greater Occipital Nerve Pulsed Radiofrequency (GONPRF)\n\nIntervention Type: Procedure\n\nDescription: GONPRF applied at C2 under ultrasound guidance in addition to standard care, starting at enrollment. Follow-up at 1, 3, and 6 months.",[18],"Procedure: Greater Occipital Nerve Pulsed Radiofrequency",{"label":20,"type":10,"description":21,"interventionNames":22},"Arm 3: Modified GONPRF (Group A2)","Intervention Name: Greater Occipital Nerve Pulsed Radiofrequency (GONPRF) - Second Line\n\nIntervention Type: Procedure\n\nDescription: Participants initially on standard care who do not achieve ≥50% improvement at 1 month receive GONPRF as a second-line intervention, alongside continued standard care, with follow-up at 3 and 6 months.",[18],[24,30],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Greater Occipital Nerve Pulsed Radiofrequency","GONPRF applied at C2 under ultrasound guidance in addition to standard care, starting at enrollment. Follow-up at 1, 3, and 6 months.",[15,20],null,{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Standard care","Limitation of overused acute headache medications, lifestyle advice (nutrition, hydration, activity, sleep), and continuation of preventive medications. Participants who respond at 1 month continue standard care.",[9],[35],{"name":36,"role":37,"phone":38,"phoneExt":29,"email":39},"Şükriye Dadalı, MD","CONTACT","+905333316636","sukriyedadali@gmail.com",[41],{"facility":42,"status":43,"city":44,"state":29,"zip":45,"country":46,"countryCode":29,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Ankara Bilkent City Hospital","RECRUITING","Ankara","06800","Turkey (Türkiye)",{"type":48,"coordinates":49},"Point",[50,51],32.85427,39.91987,{"lat":51,"lon":50},[54,56],{"name":55,"role":37,"phone":38,"phoneExt":29,"email":39},"Sukriye Dadali, MD",{"name":36,"role":37,"phone":38,"phoneExt":29,"email":39},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Şükriye Dadalı","Pain Medicine (Algology) specialist","100620681","personalized-pulsed-radiofrequency-of-the-greater-occipital-nerve-for-medication-overuse-headache-100620681",false,"NCT07360782","Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache","Individualized Application of Occipital Nerve Pulsed Radiofrequency in Medication Overuse Headache: A Randomized Controlled Evaluation","PRIMOGON","Inclusion Criteria\n\n* Age 18-65 years\n* Diagnosed with Medication Overuse Headache (MOH) according to ICHD-3 criteria\n* No laboratory evidence of bleeding or clotting disorders\n* No active infection\n* Not pregnant and no suspicion of pregnancy\n* No history of craniocervical surgery that may alter anatomical structures at the intervention site\n* Able to understand the study procedures, provide written informed consent, and comply with treatment\n\nExclusion Criteria\n\n* Changes in preventive treatment for migraine and\u002For tension-type headache within the last 3 months\n* Severe systemic disease (e.g., uncontrolled diabetes, serious cardiovascular disease, malignancy)\n* Psychiatric disorders (including current antidepressant use or psychiatric follow-up)\n* History of alcohol or substance abuse\n* Pregnancy, breastfeeding, or plans for pregnancy in the next 12 months\n* Concurrent use of other prophylactic headache treatments","ALL","18 Years","65 Years",{"count":73,"type":74},90,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study evaluates a novel treatment approach for medication overuse headache (MOH) using greater occipital nerve pulsed radiofrequency (GONPRF).\n\nThree treatment strategies are compared:\n\nStandard Treatment: Limitation of overused acute headache medications, lifestyle counseling, and continuation of existing preventive medications.\n\nPrimary GONPRF: GONPRF administered in addition to standard treatment.\n\nModified GONPRF: GONPRF administered as a second-line intervention in individuals who do not respond adequately to standard treatment alone.\n\nThe study assesses whether GONPRF, when applied early or after an initial period of standard care, reduces monthly headache days more rapidly and effectively than standard treatment alone. Outcomes are evaluated over a 6-month follow-up period using headache diaries and scheduled clinical assessments.\n\nThis is a randomized controlled trial designed to systematically evaluate the clinical benefit of GONPRF in patients with medication overuse headache.",[80],"Medication Overuse Headache",[80,82,83],"Occipital Nerve Pulsed Radiofrequency","Headache Treatment","2026-01-26",{"date":86,"type":87},"2026-01-27","ACTUAL",{"date":84,"type":87},{"date":90,"type":74},"2027-08",{"name":5,"class":6},1]