[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633407":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":62,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":90,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active PrTMS (EEG-Guided rTMS)","ACTIVE_COMPARATOR","Participants receive personalized, EEG-guided repetitive transcranial magnetic stimulation (PrTMS) administered 5 days per week for 6 weeks, with stimulation parameters individualized and adjusted over time based on serial sEEG and neurocognitive assessments.",[13],"Device: Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham PrTMS","SHAM_COMPARATOR","Participants receive sham repetitive transcranial magnetic stimulation (rTMS) administered 5 days per week for 6 weeks using a sham coil that mimics the sound and sensation of active treatment without delivering a therapeutic magnetic field.",[19],"Device: Transcranial Magnetic Stimulation Sham",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Magnetic Stimulation","Personalized repetitive transcranial magnetic stimulation (PrTMS) is delivered using the Neurocare Apollo TMS Therapy System for 30 minutes per session, 5 days per week, over 6 weeks. Stimulation parameters (frequency 8-13 Hz and intensity typically 50-60% of motor threshold) are individualized based on baseline and serial spectral EEG (sEEG) assessments, with adjustments made throughout treatment to optimize response.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Transcranial Magnetic Stimulation Sham","Sham stimulation will be delivered using the same Neurocare Apollo TMS Therapy System as the active intervention, with identical treatment schedule (5 days per week for 6 weeks; 30 minutes per session). A sham coil identical in appearance to the active coil will be used, which does not generate a therapeutic magnetic field. To mimic the sensory experience of active treatment, the sham procedure will produce similar auditory clicking and will include a surface electrical stimulation (TENS) applied to the forehead to replicate scalp sensations and mild muscle contraction. This approach is designed to maintain blinding while delivering no active neuromodulatory effect.",[15],[32],{"name":33,"affiliation":5,"role":34},"Sofia E Matta, MD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Joseph Bonvie, PsyD","CONTACT","8572053407","jbonvie@mgh.harvard.edu",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Alan Berkeley, MBA","8572839928","aberkeley@mgh.harvard.edu",[46],{"facility":47,"status":26,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Home Base","Charlestown","Massachusetts","02129","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-71.062,42.37787,{"lat":57,"lon":56},[60,61],{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":34,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Sofia Matta","Director",[66],{"name":67,"class":68},"United States Air Force Research Laboratory","FED","100633407","personalized-repetitive-transcranial-magnetic-stimulation-prtms-for-treatment-of-post-traumatic-stress-disorder-ptsd-100633407",false,"NCT07526285","Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)","Inclusion Criteria:\n\n* Reserve or former member of the military (veteran status)\n* Age 18 years or older\n* Primary diagnosis of post-traumatic stress disorder (PTSD) confirmed by the - Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)\n* Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5) score ≥ 33, indicating clinically significant PTSD symptoms\n* Proficient in English (spoken and written) to ensure understanding of study procedures and informed consent\n\nExclusion Criteria:\n\n* History of open-skull traumatic brain injury\n* Clinically significant seizure disorder or history of manic episodes\n* Neurological conditions associated with increased risk (e.g., increased intracranial pressure, brain lesions, stroke, cerebral aneurysm)\n* Electroencephalogram (EEG) abnormalities suggesting elevated seizure risk\n* Repetitive transcranial magnetic stimulation (rTMS) within 3 months prior to screening\n* Current use of antipsychotic or anticonvulsant medications\n* Presence of intracranial implants or non-removable metal in or near the head (excluding the mouth)\n* Clinically significant or unstable medical conditions, including active suicidal ideation\n* Uncontrolled medical illness (e.g., thyroid, hepatic, cardiac, pulmonary, or renal disease)\n* Initiation of PTSD-specific treatment within the past 4 weeks (participants on a stable regimen may be eligible)\n* Pregnancy (for women of childbearing potential)\n* Any condition that, in the opinion of the investigator, may interfere with study participation or completion","ALL","18 Years",{"count":78,"type":79},100,"ESTIMATED","INTERVENTIONAL",[82],"NA","This study is testing a personalized form of brain stimulation called PrTMS as a treatment for post-traumatic stress disorder (PTSD) in military service members and veterans. Unlike standard approaches, this treatment uses a simple brainwave test (EEG) to tailor the therapy to each individual. Participants will be randomly assigned to receive either active treatment or a comparison (sham) treatment over 6 weeks. Researchers will track changes in PTSD symptoms, mood, sleep, and overall well-being, including using wearable devices to measure things like sleep and heart rate. The goal is to see whether this personalized approach can provide greater and longer-lasting relief for individuals living with PTSD.",[85],"Posttraumatic Stress Disorder (PTSD)",[23,87,88,89],"Posttraumatic Stress Disorder","Veterans","Precision Medicine","NOT_YET_RECRUITING","2026-04-10",{"date":93,"type":94},"2026-04-13","ACTUAL",{"date":96,"type":79},"2026-08-01",{"date":98,"type":79},"2029-01-31",{"name":5,"class":6},1]