[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504325":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":75,"collaborators":77,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":26,"eligibilityCriteria":89,"healthyVolunteers":85,"sex":90,"minAge":91,"maxAge":26,"enrollmentInfo":92,"targetDuration":26,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual Care","ACTIVE_COMPARATOR","The arm will represent usual care in the primary care clinics. Physicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.",[13],"Behavioral: Usual Care",{"label":15,"type":16,"description":17,"interventionNames":18},"PrecisionTx","EXPERIMENTAL","Physicians will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment. Patients will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist.",[19],"Behavioral: Precision Treatment",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Precision Treatment","Precision treatment will be informed by practice guidelines (standard of care, brief advice, and guideline awareness), plus patient-specific risk feedback and personalized tobacco treatment recommendations using patients' clinical, genetic, and biomarker information.",[15],null,{"type":22,"name":9,"description":28,"armGroupLabels":29,"otherNames":26},"Usual care will be informed by practice guidelines (standard of care, brief advice, and guideline awareness).",[9],[31],{"name":32,"affiliation":5,"role":33},"Li-Shiun Chen, ScD, MD, MPH","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":26,"email":38},"CONTACT","314-362-3932","li-shiun@wustl.edu",{"name":40,"role":36,"phone":41,"phoneExt":26,"email":42},"Alex Ramsey, PhD","314-362-5370","aramsey@wustl.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","St Louis","Missouri","63110","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-90.19789,38.62727,{"lat":55,"lon":54},[58,59,60,61,62,65,67,69,71,73],{"name":32,"role":36,"phone":37,"phoneExt":26,"email":38},{"name":40,"role":36,"phone":41,"phoneExt":26,"email":42},{"name":32,"role":33,"phone":26,"phoneExt":26,"email":26},{"name":40,"role":33,"phone":26,"phoneExt":26,"email":26},{"name":63,"role":64,"phone":26,"phoneExt":26,"email":26},"Laura Bierut, MD","SUB_INVESTIGATOR",{"name":66,"role":64,"phone":26,"phoneExt":26,"email":26},"Esther Lu, PhD",{"name":68,"role":64,"phone":26,"phoneExt":26,"email":26},"Robert Schnoll, PhD",{"name":70,"role":64,"phone":26,"phoneExt":26,"email":26},"Timothy Baker, PhD",{"name":72,"role":64,"phone":26,"phoneExt":26,"email":26},"Hilary Tindle, MD",{"name":74,"role":64,"phone":26,"phoneExt":26,"email":26},"Rachel Tyndale, PhD",{"type":76,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[78,81],{"name":79,"class":80},"National Institute on Drug Abuse (NIDA)","NIH",{"name":82,"class":80},"National Cancer Institute (NCI)","100504325","personalized-tobacco-treatment-in-primary-care-motivate-100504325",false,"NCT05846841","Personalized Tobacco Treatment in Primary Care (MOTIVATE)","A Multilevel Intervention to Personalize and Improve Tobacco Treatment in Primary Care (MOTIVATE)","Eligibility Criteria for Primary and Specialty Care Clinicians\n\n* Clinician from participating clinic\n* At least 18 years of age\n* Can speak and understand English\n\nEligibility Criteria for Primary Care and Specialty Patients\n\nInclusion:\n\n* Patient at participating clinic\n* Age 18 years or older, inclusive\n* Current smoking (cigarettes per day \\>=5)\n* Can speak and understand English\n* Willing to consider medication to help reduce craving or smoking such as nicotine patch, lozenge, or varenicline\n\nExclusion:\n\n* Active use of smoking cessation medication (within the past 30 days)\n* Receipt of smoking cessation medication or prescription for smoking cessation medication (within the past 30 days)\n* Having a contraindication for cNRT or varenicline (allergic reactions, current cardiac problems, pregnancy)","ALL","18 Years",{"count":93,"type":94},850,"ESTIMATED","INTERVENTIONAL",[97],"NA","This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This approach may increase effectiveness and adherence for the patient, and increase the clinician's likelihood of prescribing.",[100,101,102],"Physician's Role","Smoking Cessation","Smoking",[104,105,106],"genetics","primary care physicians","tobacco treatment","2026-02-05",{"date":109,"type":110},"2026-02-09","ACTUAL",{"date":112,"type":110},"2023-09-29",{"date":114,"type":94},"2028-09-30",{"name":5,"class":6},1]