[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611974":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":33,"responsibleParty":52,"collaborators":20,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":20,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":35,"whyStopped":20,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Aalborg University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Classical rTMS to M1","ACTIVE_COMPARATOR","This is a prospective, single-arm interventional study designed to evaluate the predictive value of a neurophysiological biomarker for rTMS response in chronic pain patients. Patients will be allocated to two groups according to their baseline M1 connectivity at baseline in a 1:1 proportion. Patients with \"low\" connectivity will be compared to controls having \"high\" connectivity. All patients will receive repetitive transcranial magnetic stimulation (rTMS) to the primary cortex (M1). Low connectivity will be defined by TMS-EEG evoked responses. Responses to a single pulse of TMS delivered to M1 before therapy. TMS-EEG responses will be analysed by phase- and power-based metrics such as global mean field power and inter-trial coherence in the alpha band, according to previous studies. The study main hypothesis is that pre-therapy M1 low connectivity is a predictor of response to M1 rTMS.",[13],"Device: rTMS to M1",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","rTMS to M1","• The rTMS intervention consists of 10-Hz rTMS. Thirty trains of ten seconds with an interval of twenty seconds between trains will be delivered, as traditionally performed. Each train includes 100 pulses, and the total number of pulses will be 3,000 given in 15 minutes. All patients will receive 14 sessions of rTMS.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Margit M Bach, PhD","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Margit M Bach","CONTACT","+45 9137 3170","forskning.dca@hst.aau.dk",{"name":32,"role":28,"phone":20,"phoneExt":20,"email":20},"Daniel C de Andrade",[34],{"facility":5,"status":35,"city":36,"state":20,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Gistrup","9260","Denmark","DK",{"type":41,"coordinates":42},"Point",[43,44],9.99085,56.9943,{"lat":44,"lon":43},[47,49,51],{"name":48,"role":28,"phone":29,"phoneExt":20,"email":30},"Margit M Bach, Dr",{"name":50,"role":28,"phone":20,"phoneExt":20,"email":20},"Daniel C de Andrade, Prof",{"name":48,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Margit Midtgaard Bach","Dr.","100611974","personalized-treatment-by-rtms-in-chronic-pain---study2-100611974",false,"NCT07247552","Personalized Treatment by rTMS in Chronic Pain - Study2","Personalized Pain Treatment by Transcranial Magnetic Stimulation in Patients With Chronic Pain: A Prospective Interventional Study With Embedded Predictive Biomarker Evaluation","PersoNINpain","Inclusion Criteria:\n\n* Presence of chronic pain (present most of the days for more than 3 months).\n* Pain with a mean pain intensity between 3-9 on a 0-10 pain scale (where 0 means no pain and 10 means the worst pain imaginable).\n* Speak and understand English or Danish\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding\n* Current uncontrolled major depression as the main diagnosis\n* Current history of substance abuse\n* Lack of ability to cooperate, to fully understand the protocol or any difficulty in filling out questionnaires (e.g., due to language or cognitive problems)\n* Formal contraindications to TMS application (presence of epilepsy, cranial implanted ferromagnetic devices, e.g., intracranial neurostimulator or cochlear implants, tattoos with metal ink on the face or permanent make up with metal in the face )\n* Unable to answer the \"Transcranial Magnetic Stimulation Adult Safety Screen\" screening questionnaire.\n* Participation in other research protocols within 1 month before the inclusion.","ALL","18 Years","80 Years",{"count":67,"type":68},90,"ESTIMATED","INTERVENTIONAL",[71],"NA","Previous research has shown the effectiveness of magnetic stimulation of the brain as a supplemental treatment for various conditions, such as depression and chronic pain. However, the application of magnetic stimulation has been standardized across patients without considering individual differences. This one-size-fits-all approach results in only half of the patients benefiting from the treatment, with the other half seeing no improvement in their symptoms. Therefore, a study on individuals with chronic pain will be performed to explore how magnetic stimulation treatments can be tailored to each person. This will involve analysing brain signal measurements before the start of the therapy and adjusting\u002Fpersonalizing the magnetic stimulations to each individual person.",[74],"Chronic Pain",[76,77,78,79,74,80,81],"Pain","Neurologic Manifestations","Signs and Symptoms","Pathological Conditions, Signs and Symptoms","Transcranial Magnetic Stimulation","Neuromodulation","2025-11-24",{"date":84,"type":85},"2025-12-01","ACTUAL",{"date":87,"type":85},"2025-04-01",{"date":89,"type":68},"2026-06",{"name":5,"class":6},1]