[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100374167":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":87,"centralContacts":92,"locations":99,"responsibleParty":120,"collaborators":122,"id":126,"slug":127,"hasResults":128,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":97,"eligibilityCriteria":132,"healthyVolunteers":128,"sex":133,"minAge":134,"maxAge":97,"enrollmentInfo":135,"targetDuration":97,"studyType":138,"phases":139,"briefSummary":141,"conditions":142,"keywords":146,"overallStatus":101,"whyStopped":97,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},{"fullName":5,"class":6},"University of Washington","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Research (PET\u002FCT scan)","EXPERIMENTAL","Patients undergo PET\u002FCT scan within 4 weeks before starting standard of care chemoimmunotherapy and a second PET\u002FCT scan within 5 days of the second chemoimmunotherapy cycle. Patients receiving standard of care radiation treatment undergo additional PET\u002FCT scans within 4 weeks prior to radiation treatment and 1 month post-radiation treatment. Additionally, patients undergo blood sample collection on study. Patients may also undergo MRI as clinically indicated throughout the study.",[13,14,15,16,17,18,19],"Procedure: Positron Emission Tomography","Procedure: Computed Tomography","Drug: Chemotherapy","Biological: Immunotherapy","Radiation: Radiation Therapy","Procedure: Biospecimen Collection","Procedure: Magnetic Resonance Imaging",[21,33,43,51,60,74,80],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Positron Emission Tomography","Undergo PET\u002FCT scan",[9],[27,28,29,30,31,32],"Medical Imaging","PET","PET scan","positron emission tomography scan","Positron-Emission Tomography","PT",{"type":22,"name":34,"description":24,"armGroupLabels":35,"otherNames":36},"Computed Tomography",[9],[37,38,39,40,41,42],"CAT","CAT Scan","computerized axial tomography","computerized tomography","CT","CT SCAN",{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DRUG","Chemotherapy","Receive standard of care chemotherapy",[9],[49,50],"Chemo","Chemotherapy (NOS)",{"type":52,"name":53,"description":54,"armGroupLabels":55,"otherNames":56},"BIOLOGICAL","Immunotherapy","Receive standard of care immunotherapy",[9],[57,58,59],"Immunological","Immunological Therapy","Immunologically Directed Therapy",{"type":61,"name":62,"description":63,"armGroupLabels":64,"otherNames":65},"RADIATION","Radiation Therapy","Undergo standard of care radiation therapy",[9],[66,67,68,69,70,71,72,73],"Cancer Radiotherapy","Irradiate","irradiated","Irradiation","Radiation","Radiotherapeutics","radiotherapy","RT",{"type":22,"name":75,"description":76,"armGroupLabels":77,"otherNames":78},"Biospecimen Collection","Undergo blood sample collection",[9],[79],"Biological Sample Collection",{"type":22,"name":81,"description":82,"armGroupLabels":83,"otherNames":84},"Magnetic Resonance Imaging","Undergo MRI",[9],[85,86],"MRI","MRI Scan",[88],{"name":89,"affiliation":90,"role":91},"Lei Deng, MD","Fred Hutch\u002FUniversity of Washington Cancer Consortium","PRINCIPAL_INVESTIGATOR",[93],{"name":94,"role":95,"phone":96,"phoneExt":97,"email":98},"Stephen R. Bowen, PhD","CONTACT","206-543-6559",null,"srbowen@uw.edu",[100],{"facility":90,"status":101,"city":102,"state":103,"zip":104,"country":105,"countryCode":106,"cosmosGeoPoint":107,"geoPoint":112,"contacts":113},"RECRUITING","Seattle","Washington","98109","United States","US",{"type":108,"coordinates":109},"Point",[110,111],-122.33207,47.60621,{"lat":111,"lon":110},[114,115,117,119],{"name":94,"role":95,"phone":96,"phoneExt":97,"email":98},{"name":94,"role":116,"phone":97,"phoneExt":97,"email":97},"SUB_INVESTIGATOR",{"name":118,"role":116,"phone":97,"phoneExt":97,"email":97},"Jing Zeng, MD",{"name":89,"role":91,"phone":97,"phoneExt":97,"email":97},{"type":121,"investigatorFullName":97,"investigatorTitle":97,"investigatorAffiliation":97,"oldNameTitle":97,"oldOrganization":97},"SPONSOR",[123],{"name":124,"class":125},"National Cancer Institute (NCI)","NIH","100374167","petct-changes-during-chemoimmunotherapy-and-radiation-therapy-in-patients-with-stage-iv-non-small-cell-lung-cancer-100374167",false,"NCT04151940","PET\u002FCT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung Cancer","An Interventional Study of PET\u002FCT Changes During Chemoimmunotherapy and Radiation Therapy for Patients With Metastatic NSCLC (PET Bright)","Inclusion Criteria:\n\n* Histologically-confirmed or cytologically-confirmed metastatic NSCLC in patients who have not received chemotherapy or immunotherapy for their advanced disease (stage IV or recurrent, using the American Joint Committee on Cancer \\[AJCC\\]\u002FUnion for International Cancer Control \\[UICC\\] 8th edition for staging)\n* Evidence of stage IV disease on imaging by CT, PET\u002FCT, or magnetic resonance imaging (MRI)\n* Plan to treat with a platinum doublet with a PD1 or PDL1 inhibitor\n* Adjuvant chemotherapy or concurrent chemoradiation for early stage disease does not count as prior therapy unless subject progressed within 6 months of completion of regimen.\n* Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1, at treating physician's discretion\n* Subjects must be ≥ 18 years of age\n* Patients with known activating mutations in EGFR, BRAF or known translocation in ALK or ROS-1 are eligible provided they have progressed on or were intolerant to Food and Drug Administration (FDA) approved targeted therapy\n* Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2\n* Creatinine =\\\u003C 2 mg\u002FdL or creatinine clearance \\> 50 mL\u002Fmin\n* Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \\[SGOT\\])\u002Falanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \\[SGPT\\]) =\\\u003C 5x institutional upper limit of normal\n* Total bilirubin =\\\u003C 1.5 mg\u002FdL\n* Absolute neutrophil count (ANC) \\>= 1.5 x 10\\^9\u002FL (\\>= 1500 per mm\\^3)\n* Platelet count \\>= 100 x 10\\^9\u002FL (\\>=100,000 per mm\\^3)\n* Capability to understand and comply with the protocol requirements and signed informed consent documents\n\nExclusion Criteria:\n\n* Any known additional malignancy (with exception of non-melanoma skin cancer, in-situ breast cancer, low risk prostate cancer, or a malignancy diagnosed \\>= 3 years prior to the current NSCLC diagnosis and with no evidence of requiring active treatment)\n* Had prior treatment with an anti-PD-1, or PD-L1 or PD-L2 agent or an antibody targeting other immuno-regulatory receptors or mechanisms\n* Has any serious or uncontrolled active infection that could create false positives on a PET\u002FCT scan, in the opinion of the treating investigator\n* Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator\n* Has an active autoimmune disease currently requiring systemic treatment (e.g. disease modifying agents, corticosteroids or immunosuppressive drugs)\n\n  \\*\\*Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment\n* Has known, active, and symptomatic central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n\n  * Patients with stable or previously treated brain metastases are eligible as long as they are not receiving more than 10 mg of prednisone, or equivalent, per day","ALL","18 Years",{"count":136,"type":137},80,"ESTIMATED","INTERVENTIONAL",[140],"NA","This study investigates the changes in positron emission tomography (PET)\u002Fcomputed tomography (CT) imaging scans during chemoimmunotherapy and radiation therapy treatment in patients with stage IV non-small cell lung cancer. Analyzing changes in PET\u002FCT imaging scans may help doctors assess and predict patterns of cancer response to chemoimmunotherapy and radiation therapy.",[143,144,145],"Metastatic Lung Non-Small Cell Carcinoma","Recurrent Lung Non-Small Cell Carcinoma","Stage IV Lung Cancer AJCC v8",[147],"Lung","2026-01-12",{"date":150,"type":151},"2026-01-14","ACTUAL",{"date":153,"type":151},"2019-09-26",{"date":155,"type":137},"2027-11-30",{"name":5,"class":6},1]