[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568522":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":56,"collaborators":58,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":7,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":7,"enrollmentInfo":73,"targetDuration":7,"studyType":76,"phases":7,"briefSummary":77,"conditions":78,"keywords":7,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Pontificia Universidad Catolica de Chile","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Multi-drug interaction","The clinical impact associated with the use of multiple drugs in liver transplant patients during their stay in ICU will be evaluated.",[13],{"name":14,"affiliation":5,"role":15},"Nelson Barrera, PhD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":7,"email":20},"CONTACT","56987687058","nbarrerr@uc.cl",[22,41,47],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Hospital ClínicoUC-Christus","RECRUITING","Santiago","Santiago Metropolitan","8330024","Chile","CL",{"type":31,"coordinates":32},"Point",[33,34],-70.64827,-33.45694,{"lat":34,"lon":33},[37,38,40],{"name":14,"role":18,"phone":19,"phoneExt":7,"email":20},{"name":39,"role":18,"phone":7,"phoneExt":7,"email":7},"Jaime Retamal, PhD",{"name":14,"role":18,"phone":7,"phoneExt":7,"email":7},{"facility":42,"status":43,"city":25,"state":26,"zip":7,"country":28,"countryCode":29,"cosmosGeoPoint":44,"geoPoint":46,"contacts":7},"Pontificia Universidad Católica de Chile","ACTIVE_NOT_RECRUITING",{"type":31,"coordinates":45},[33,34],{"lat":34,"lon":33},{"facility":48,"status":43,"city":49,"state":50,"zip":7,"country":28,"countryCode":29,"cosmosGeoPoint":51,"geoPoint":55,"contacts":7},"Universidad de Valparaíso","Valparaíso","Valparaiso",{"type":31,"coordinates":52},[53,54],-71.62963,-33.036,{"lat":54,"lon":53},{"type":57,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[59,61],{"name":60,"class":6},"Universidad de Valparaiso",{"name":62,"class":63},"Universidad Adolfo Ibañez","UNKNOWN","100568522","pharmaco-proteomic-platform-to-evaluate-drug-interactions-in-liver-transplant-patients-100568522",false,"NCT06682325","Pharmaco-proteomic Platform to Evaluate Drug Interactions in Liver Transplant Patients","Development of a Pharmaco-proteomic Platform to Evaluate Potential Drug Interactions and Their Clinical Impact in Liver Transplant Patients Undergoing Multidrug Treatment","Inclusion Criteria:\n\n* Liver transplant patients undergoing surgery at UC Christus Hospital\n\nExclusion Criteria:\n\n* Patients on renal replacement therapy\n* Patients for whom no clinical or pharmacological registry is available","ALL","18 Years",{"count":74,"type":75},48,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to enhance the ability to forecast kidney failure in liver transplant patients in the ICU under multidrug treatment by developing a computer platform that integrates mathematical models of drug interactions, proteomics, and clinical data. The main outcomes it aims to develop are:\n\n1. Design the multidrug web computing platform with available information on drug pair interactions (DDIs).\n2. Integrate the proteomic and clinical data of liver transplant patients into the IT platform.\n3. Implement the multidrug web platform to predict the clinical evolution of liver transplant patients.",[79,80],"Drug-drug Interaction","Liver Transplantation","2024-11-07",{"date":83,"type":84},"2024-11-12","ACTUAL",{"date":86,"type":84},"2023-06-01",{"date":88,"type":75},"2025-05-05",{"name":5,"class":6},3]