[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100478607":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":22,"locations":32,"responsibleParty":67,"collaborators":70,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":107,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"University of Geneva, Switzerland","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Newly diagnosed ALL Children with age group of >1 and ≤18 years old",null,"Newly diagnosed ALL Children who are likely to receive anti-cancer drugs or chemotherapy as a part of IciCLE treatment protocol.",[13,16,19],{"name":14,"affiliation":5,"role":15},"Chakradhara Rao S UPPUGUNDURI","PRINCIPAL_INVESTIGATOR",{"name":17,"affiliation":18,"role":15},"Biswajit DUBASHI","Jawaharlal Institute of Postgraduate Medical Education & Research",{"name":20,"affiliation":21,"role":15},"Sameer BAKHSHI","All India Instiutte of Medical Scineces",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Chakradhara Rao S Uppugudnuri","CONTACT","+41223794685","chakradhara.uppugunduri@unige.ch",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Marc Ansari","+41223724731","Marc.Ansari@hcuge.ch",[33,52],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Dr. Sameer Bakhshi","RECRUITING","New Delhi","110029","India","IN",{"type":41,"coordinates":42},"Point",[43,44],77.2148,28.62137,{"lat":44,"lon":43},[47,51],{"name":48,"role":25,"phone":49,"phoneExt":10,"email":50},"Sameer Bakhshi, MD","+911126588500","sambakh@hotmail.com",{"name":48,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":53,"status":35,"city":54,"state":10,"zip":55,"country":38,"countryCode":39,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Dr. Biswajit Dubashi","Puducherry","605006",{"type":41,"coordinates":57},[58,59],79.82979,11.93381,{"lat":59,"lon":58},[62,66],{"name":63,"role":25,"phone":64,"phoneExt":10,"email":65},"Biswajit Dubashi, D.M","+914132297313","drbiswajitdm@gmail.com",{"name":63,"role":15,"phone":10,"phoneExt":10,"email":10},{"type":15,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Uppugunduri S Chakradhara Rao","Collaborator Scientific II & Principal Investigator",[71,73,75,77,79],{"name":18,"class":72},"OTHER_GOV",{"name":74,"class":6},"All India Institute of Medical Sciences",{"name":76,"class":6},"Swiss National Science Foundation",{"name":78,"class":72},"Ministry of Science and Technology, India",{"name":80,"class":81},"CANSEARCH Foundation","UNKNOWN","100478607","pharmacogenomic-association-study-in-indian-children-with-acute-lymphoblastic-leukemia-100478607",false,"NCT05512169","Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia","Molecular and Pharmacogenetic Marker Evaluation in Relation to the Toxicity and Clinical Response of Acute Lymphoblastic Leukemia Treatment in Indian Children (MPGx-INDALL)","MPGx-INDALL","Inclusion Criteria:\n\n* Age \\> 1 year old and ≤18 years old at enrolment\n* Previously untreated\n* ALL diagnosis confirmed by morphology and flow-cytometry\n* Indian origins\n* Fulfilling IciCle treatment protocol inclusion criteria and receiving treatment as per the protocol\n* Written Informed consent to participate in the study has to be signed by the participant\u002Fparent\u002Fguardian\n\nExclusion Criteria:\n\n* Previously tretaed patients\n* Patients with Down's syndrome\n* Patients with mature B-ALL","ALL","1 Year","18 Years",{"count":94,"type":95},556,"ESTIMATED","OBSERVATIONAL","A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL). The project is an International multicenter setup. This collaborative research project between Switzerland and India includes one main center in Geneva that has conceptualized, designed, received grants for the study and two investigating centers in India (Puducherry and New-Delhi) involved in study design, patient care and recruitment for this specific study. All the participants for the study will be recruited form these two centers in India, and no patient recruitment is planned at main center i.e. Geneva.\n\nThe study will be conducted in two phases. The first aims to investigate genetic predisposition (static germline variants) to early chemotherapy treatment related toxicities (TRTs). The second aims to investigate somatic genetic markers associated with the efficacy of steroid treatment among patients undergoing the standardized IciCLe-ALL-14 treatment protocol. A total of 500 children with ALL will be recruited to investigate primary objective of the study i.e. TRT, and a subset of 250 patients will be included to investigate another research question i.e. response to steroid therapy.",[99,100,101,102,103,104,105,106],"ALL, Childhood","Pediatric Cancer","Toxicity, Drug","Adverse Drug Event","Relapse Leukemia","Drug Toxicity","Drug Effect","Drug Interaction",[108,109,110,111,112,113,114,115,116,117,118,119,120,121],"Pharmacogenetics","Pharmacogenomics","Genetic polymorphism","Sequencing","Genotyping","Indian","Pediatrics","SNP","gene variant","germline genetic variant","somatic variant","biomarker","steroid response","genetic predisposition","2026-01-13",{"date":124,"type":125},"2026-01-15","ACTUAL",{"date":127,"type":125},"2022-12-01",{"date":129,"type":95},"2027-03-30",{"name":5,"class":6},2]