[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623243":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":39,"locations":50,"responsibleParty":63,"collaborators":30,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":30,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":96,"whyStopped":30,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Fundacion Clinic per a la Recerca Biomédica","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Red Wine","EXPERIMENTAL","Participants will consume 100 mL of red wine, providing a standardized dose of tartaric acid, after a 10-hour overnight fast. The wine will be ingested within 5 minutes, accompanied by a standardized meal (2 slices of white bread) to simulate real-life consumption conditions. Intake of other fluids will be controlled (water ad libitum except during the first hour), and compliance will be monitored through direct observation.",[13],"Dietary Supplement: Wine",{"label":15,"type":10,"description":16,"interventionNames":17},"Grape fruits","Participants will consume a portion of fresh grapes containing an equivalent dose of tartaric acid to the wine, following the same controlled conditions: after a 10-hour overnight fast, ingested within 5 minutes with the standardized meal, with controlled fluid intake and direct compliance monitoring.",[18],"Dietary Supplement: Grape",{"label":20,"type":10,"description":21,"interventionNames":22},"Grape juice","Participants will consume 150 mL of grape juice standardized for tartaric acid content, under identical conditions: after a 10-hour overnight fast, ingested within 5 minutes with the standardized meal, with controlled fluid intake and compliance monitoring.",[23],"Dietary Supplement: Juice",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","Wine","100 mL of red wine containing a standardized dose of tartaric acid, ingested after a 10-hour overnight fast with a standardized meal (2 slices of white bread). Consumption completed within 5 minutes, fluid intake controlled, compliance monitored.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Grape","Portion of fresh grapes providing an equivalent dose of tartaric acid as the wine, consumed under the same controlled conditions.",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Juice","150 mL of grape juice standardized for tartaric acid content, ingested under identical conditions as the other arms.",[20],[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Anallely López Yerena, PI","CONTACT","932275400","2907","nayelopezye@ub.edu",{"name":47,"role":42,"phone":48,"phoneExt":30,"email":49},"Rosa M. Lamuela-Raventós, Co-PI","Lamuela-Raventós","lamuela@ub.edu",[51],{"facility":52,"status":30,"city":53,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":30},"Department of Internal Medicine, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer","Barcelona","08036","Spain","ES",{"type":58,"coordinates":59},"Point",[60,61],2.15899,41.38879,{"lat":61,"lon":60},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Anallely Lopez","Postdoctoral Researcher","100623243","pharmacokinetic-characterization-of-tartaric-acid-in-humans-100623243",false,"NCT07394101","Pharmacokinetic Characterization of Tartaric Acid in Humans","Pharmacokinetic Characterization of Tartaric Acid in Humans: Effect of the Food Matrix (Wine, Grapes, and Juice) on Its Bioavailability","TARBIO","Inclusion Criteria:\n\n* Healthy non-smoking adults aged 20-40 years.\n* Body mass index (BMI) between 23 and 27 kg\u002Fm².\n* No history of cardiovascular, hepatic, or renal disease.\n* No adherence to any special diet for at least 4 weeks prior to the study.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Current smokers or recent ex-smokers.\n* History of cardiovascular, hepatic, or renal disorders.\n* Current adherence to any special diet or nutritional supplementation that could affect study outcomes.\n* Any condition or medication that could interfere with absorption, metabolism, or excretion of tartaric acid.\n* Participation in another clinical trial within the past 3 months.\n* Pregnancy or lactation.",true,"ALL","20 Years","40 Years",{"count":80,"type":81},30,"ESTIMATED","INTERVENTIONAL",[84],"NA","The goal of this clinical trial is to characterize the pharmacokinetics (absorption, distribution, metabolism, and excretion; ADME) and oral bioavailability of tartaric acid in humans after its administration through different food matrices (red wine, fresh grapes, and grape juice). The study aims to determine whether the pharmacokinetic behavior of tartaric acid is matrix-dependent and dose-dependent in healthy adult volunteers.\n\nThe main questions it aims to answer are:\n\nDoes the food matrix (wine, grapes, or grape juice) influence the oral bioavailability of tartaric acid?\n\nAre there differences in key pharmacokinetic parameters of tartaric acid, including maximum plasma concentration (Cmax), time to reach maximum concentration (Tmax), total exposure (AUC), half-life (t1\u002F2), and urinary excretion, depending on the matrix of intake?\n\nResearchers will compare the pharmacokinetic profiles of tartaric acid after consumption in red wine, grapes, and grape juice to evaluate differences in absorption, systemic exposure, and elimination attributable to the source of intake.\n\nParticipants will:\n\nFollow a polyphenol-restricted diet prior to the study, including avoidance of grapes, wine, and related products.\n\nConsume a single standardized dose of tartaric acid administered as red wine, fresh grapes, or grape juice after an overnight fast.\n\nProvide blood samples at multiple time points over a 24-hour period to determine plasma tartaric acid concentrations.\n\nCollect urine samples over 24 hours for assessment of tartaric acid excretion.\n\nConsume standardized low-polyphenol meals under controlled conditions during the study day.",[87,88,89],"Healthy Adult Participants","Non-smoking, Healthy Adults","Normal Weight Adults",[91,92,93,94,27,95],"Tartaric acid","Pharmacokinetics","Bioavailability","Food matrix effect","Healthy volunteers","NOT_YET_RECRUITING","2026-02-02",{"date":99,"type":100},"2026-02-06","ACTUAL",{"date":102,"type":81},"2026-04",{"date":104,"type":81},"2026-05",{"name":5,"class":6},1]