[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572084":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":55,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Zhejiang Cancer Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravenous infusion of TXA","ACTIVE_COMPARATOR","Slowly infuse 1g TXA at a rate of approximately 1 ml\u002Fmin.",[13],"Behavioral: Tranexamic acid Intravenous Infusion",{"label":15,"type":16,"description":17,"interventionNames":18},"Intramuscular injection of TXA","EXPERIMENTAL","1g TXA is administered with twice intramuscular injections, and each injection takes no more than 30 seconds. The injection site is chosen as the deltoid or lateral thigh muscle.",[19],"Behavioral: TXA intramuscular injection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Tranexamic acid Intravenous Infusion","A slow intravenous infusion of 1g TXA was administered at a rate of about 1ml\u002Fmin.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"TXA intramuscular injection","5ml intramuscular injections of TXA with twice, each injection time no more than 30 seconds, the injection site was selected as triangle",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Yejing Zhu, PHD","CONTACT","86+18758096745","zhuyejing1983@126.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Hangzhou","Zhejiang","310022","China","CN",{"type":46,"coordinates":47},"Point",[48,49],120.16142,30.29365,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":53,"phoneExt":26,"email":54},"+86-18758096745","zhuyj@zjcc.org.cn",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Zhu Yejing","MD","100572084","pharmacokinetic-study-of-tranexamic-acid-100572084",false,"NCT06728670","Pharmacokinetic Study of Tranexamic Acid","Pharmacokinetic Study and Clinical Efficacy Observation of Different Routes of Tranexamic Acid Infusion in Advanced Ovarian Cancer Cell Reduction Surgery","Inclusion Criteria:\n\n1. Adult women aged 20-64 diagnosed with advanced ovarian cancer undergoing cytoreductive surgery\n2. The cancer stage is III-IV\n3. ASA classification II-III\n4. Surgical duration\\>2 hours\n\nExclusion Criteria:\n\n1. Renal dysfunction (serum creatinine\\>200 mmol\u002FL) or liver dysfunction (Child Turcote classification\\>6)\n2. Has a history of serious mental illness or disorders, epilepsy, visual impairment\n3. Previous or current bleeding disorders, coagulation dysfunction, or thromboembolic events\n4. Lower limb venous thrombosis\n5. Anticoagulants or antifibrinolytic drugs used before surgery within the past month\n6. Allergic to TXA","FEMALE","20 Years","64 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","Tranexamic acid is an effective anti fibrinolytic drug. Clinical studies have found that intravenous injection of tranexamic acid is more effective in reducing blood loss and transfusion in patients with advanced ovarian cancer, without increasing the risk of postoperative complications. Different surgeries and administration routes have an impact on the pharmacokinetics and pharmacodynamics of TXA. At present, there is little data on the pharmacokinetics of intramuscular injection of TXA, and almost all of the data comes from males. For ovarian cancer patients, there are currently no reports on the pharmacokinetics of TXA through different routes of administration, such as intramuscular and intravenous administration. Therefore, the investigators chose ovarian cancer patients and administered it through different routes of intravenous and intramuscular injection.",[77],"Ovarian Neoplasm Epithelial",[79,80],"Tranexamic acid","pharmacokinetics","2024-12-07",{"date":83,"type":84},"2024-12-11","ACTUAL",{"date":86,"type":84},"2024-11-20",{"date":88,"type":71},"2025-08-31",{"name":5,"class":6},1]