[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515583":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":34,"centralContacts":38,"locations":44,"responsibleParty":66,"collaborators":23,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":23,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":23,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":46,"whyStopped":23,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Seoul National University Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Sugammadex group","EXPERIMENTAL","Patient is intubated with etomidate 0.1\\~0.2mg\u002Fkg and rocuronium 1mg\u002Fkg. 30 minutes after rocuronium administration, patient is administered sugammadex 1mg\u002Fkg. Glasgow coma scale as neurologic assessment is assessed at 10-minute intervals before intubation, and at 5-minute intervals up to 30 minutes after administration of sugammadex. After 30 minutes, the assessments are conducted at 10-minute intervals. Additionally, if the patient spontaneously opens their eyes, the GCS is assessed at that specific moment. The GCS evaluation continues until the patient reaches a point of responsiveness, indicated by a Motor score of 6 on the GCS.",[13],"Drug: Sugammadex",{"label":15,"type":10,"description":16,"interventionNames":17},"Neostigmine group","Patient is intubated with etomidate 0.1\\~0.2mg\u002Fkg and rocuronium 1mg\u002Fkg. 30 minutes after rocuronium administration, patient is administered neostigmine 0.05mg\u002Fkg + glycopyrrolate 0.01mg\u002Fkg. Glasgow coma scale as neurologic assessment is assessed at 10-minute intervals before intubation, and at 5-minute intervals up to 30 minutes after administration of neostigmine. After 30 minutes, the assessments are conducted at 10-minute intervals. Additionally, if the patient spontaneously opens their eyes, the GCS is assessed at that specific moment. The GCS evaluation continues until the patient reaches a point of responsiveness, indicated by a Motor score of 6 on the GCS.",[18],"Drug: Neostigmine",{"label":20,"type":21,"description":22,"interventionNames":23},"Control group","NO_INTERVENTION","Patient is intubated with etomidate 0.1\\~0.2mg\u002Fkg and rocuronium 1mg\u002Fkg. Glasgow coma scale as neurologic assessment is assessed at 10-minute intervals before intubation, and at 5-minute intervals up to 60 minutes after intubation. After 60 minutes, the assessments are conducted at 10-minute intervals. Additionally, if the patient spontaneously opens their eyes, the GCS is assessed at that specific moment. The GCS evaluation continues until the patient reaches a point of responsiveness, indicated by a Motor score of 6 on the GCS.",null,[25,30],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":23},"DRUG","Sugammadex","Intravenous administration of sugammadex 2mg\u002Fkg.",[9],{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":23},"Neostigmine","Intravenous administration of neostigmine 0.05mg\u002Fkg with glycopyrrolate 0.01mg\u002Fkg",[15],[35],{"name":36,"affiliation":5,"role":37},"Ho Geol Ryu, M.D., Ph.D","STUDY_CHAIR",[39],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},"Leerang Lim, MD","CONTACT","+82-10-5063-1742","erange@snu.ac.kr",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":23,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Seoul","Jongno-gu","03080","South Korea",{"type":52,"coordinates":53},"Point",[54,55],126.9784,37.566,{"lat":55,"lon":54},[58,63],{"name":59,"role":41,"phone":60,"phoneExt":61,"email":62},"Hogeol Ryu, MD, PhD","+82220722469","82-2-2072-2469","hogeol@gmail.com",{"name":40,"role":41,"phone":64,"phoneExt":65,"email":43},"+82-2072-2469","82-2-2072-1683",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Ho Geol Ryu","Professor","100515583","pharmacological-reversal-of-neuromuscular-blockade-in-critically-ill-patients-100515583",false,"NCT05993390","Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients","Effect of Neuromuscular Reversal Agents on Time for Neurological Assessment After Endotracheal Intubation in Critically Ill Patients","Inclusion Criteria:\n\n* Adult patients 19 years of age or older who were intubated after admission to the intensive care unit.\n\nExclusion Criteria:\n\n* Patients younger than 19 years of age\n* Patients who are not neurologically evaluable or have concomitant neurologic dysfunction\n* Patients with neuromuscular disorder\n* Patients with a history of drug allergic reactions to sugammadex or neostigmine\n* Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives","ALL","19 Years","90 Years",{"count":81,"type":82},30,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation\n\nThe main questions it aims to answer are:\n\n* The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment.\n* The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment.\n\nParticipants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded.\n\nResearchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.",[88,89,90],"Neuromuscular Blockade","Critical Illness","Neurologic Findings",[92,93,94,95],"Reversal of neuromuscular blockade","Neurologic assessment","Endotracheal intubation","Critically ill patient","2026-05-30",{"date":98,"type":99},"2026-06-02","ACTUAL",{"date":101,"type":99},"2024-01-11",{"date":103,"type":82},"2028-04-30",{"name":5,"class":6},1]