[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610439":3},{"organization":4,"armGroups":7,"interventions":32,"overallOfficials":63,"centralContacts":67,"locations":73,"responsibleParty":473,"collaborators":475,"id":478,"slug":52,"hasResults":479,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":52,"eligibilityCriteria":483,"healthyVolunteers":479,"sex":484,"minAge":485,"maxAge":52,"enrollmentInfo":486,"targetDuration":52,"studyType":489,"phases":490,"briefSummary":493,"conditions":494,"keywords":52,"overallStatus":76,"whyStopped":52,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":505},{"fullName":5,"class":6},"Merck Sharp & Dohme LLC","INDUSTRY",[8,16,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1, Parts A and B: Gocataming + I-DXd","EXPERIMENTAL","Participants who completed standard of care (SOC) induction chemotherapy with concurrent approved anti-programmed cell death 1\u002Fligand 1 protein (anti-PD-1\u002FL1) treatment for ES-SCLC and did not have disease progression per investigator discretion, will receive gocatamig and I-DXd in the maintenance phase, until documented disease progression or meeting other study discontinuation criteria.",[13,14,15],"Drug: Gocatamig","Drug: I-DXd","Drug: Rescue Medications",{"label":17,"type":10,"description":18,"interventionNames":19},"Arm 2, Parts A and B: Gocataming + I-DXd","Participants who did not receive prior systemic treatment for ES-SCLC will receive gocatamig and I-DXd during induction and maintenance phases, until documented disease progression or meeting other study discontinuation criteria.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Arm 3, Part B: Gocataming + I-DXd → gocatamig + atezolizumab","Participants who did not receive prior systemic treatment for ES-SCLC will receive gocatamig and I-DXd in the induction phase, followed by gocatamig and atezolizumab in the maintenance phase, until documented disease progression or meeting other study discontinuation criteria.",[13,14,24,15],"Drug: Atezolizumab",{"label":26,"type":27,"description":28,"interventionNames":29},"Arm 4, Part B: Carboplatin + etoposide + atezolizumab → atezolizumab","ACTIVE_COMPARATOR","Participants who did not receive prior systemic treatment for ES-SCLC will receive SOC (carboplatin + etoposide + atezolizumab) in the induction phase, followed by atezolizumab in the maintenance phase, until documented disease progression or meeting other study discontinuation criteria.",[24,30,31],"Drug: Carboplatin","Drug: Etoposide",[33,42,49,53,56,59],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DRUG","Gocatamig","Intravenous (IV) administration",[9,17,21],[39,40,41],"MK-6070","HPN328","DS-3280",{"type":34,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"I-DXd","IV administration",[9,17,21],[47,48],"MK-2400","DS-7300a",{"type":34,"name":50,"description":44,"armGroupLabels":51,"otherNames":52},"Atezolizumab",[21,26],null,{"type":34,"name":54,"description":44,"armGroupLabels":55,"otherNames":52},"Carboplatin",[26],{"type":34,"name":57,"description":44,"armGroupLabels":58,"otherNames":52},"Etoposide",[26],{"type":34,"name":60,"description":61,"armGroupLabels":62,"otherNames":52},"Rescue Medications","Participants will receive rescue medications at the investigator's discretion. Recommended rescue medications include tocilizumab for treatment of cytokine release syndrome (CRS); dexamethasone, acetaminophen, and diphenhydramine for CRS\u002Finfusion-related reaction (IRR) prophylaxis; and 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, neurokinin 1 (NK-1) receptor antagonist, and corticosteroid for prevention of nausea and vomiting.",[9,17,21],[64],{"name":65,"affiliation":5,"role":66},"Medical Director","STUDY_DIRECTOR",[68],{"name":69,"role":70,"phone":71,"phoneExt":52,"email":72},"Toll Free Number","CONTACT","1-888-577-8839","Trialsites@msd.com",[74,92,105,118,131,144,157,170,183,195,207,220,233,243,255,270,279,288,303,316,328,341,354,367,380,392,406,418,431,440,449,458],{"facility":75,"status":76,"city":77,"state":78,"zip":79,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":88},"Providence Medical Foundation ( Site 0124)","RECRUITING","Santa Rosa","California","95403","United States","US",{"type":83,"coordinates":84},"Point",[85,86],-122.71443,38.44047,{"lat":86,"lon":85},[89],{"name":90,"role":70,"phone":91,"phoneExt":52,"email":52},"Study Coordinator","707-521-3830",{"facility":93,"status":76,"city":94,"state":95,"zip":96,"country":80,"countryCode":81,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Orlando Health Cancer Institute ( Site 0108)","Orlando","Florida","32806",{"type":83,"coordinates":98},[99,100],-81.37924,28.53834,{"lat":100,"lon":99},[103],{"name":90,"role":70,"phone":104,"phoneExt":52,"email":52},"321-841-1869",{"facility":106,"status":76,"city":107,"state":108,"zip":109,"country":80,"countryCode":81,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Saint Elizabeth Medical Center Edgewood ( Site 0112)","Edgewood","Kentucky","41017",{"type":83,"coordinates":111},[112,113],-84.58189,39.01867,{"lat":113,"lon":112},[116],{"name":90,"role":70,"phone":117,"phoneExt":52,"email":52},"859-301-4000",{"facility":119,"status":76,"city":120,"state":121,"zip":122,"country":80,"countryCode":81,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Washington University School of Medicine ( Site 0134)","St Louis","Missouri","63110",{"type":83,"coordinates":124},[125,126],-90.19789,38.62727,{"lat":126,"lon":125},[129],{"name":90,"role":70,"phone":130,"phoneExt":52,"email":52},"314-747-1171",{"facility":132,"status":76,"city":133,"state":134,"zip":135,"country":80,"countryCode":81,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"John Theurer Cancer Center at Hackensack University Medical Center ( Site 0101)","Hackensack","New Jersey","07601",{"type":83,"coordinates":137},[138,139],-74.04347,40.88593,{"lat":139,"lon":138},[142],{"name":90,"role":70,"phone":143,"phoneExt":52,"email":52},"551-996-5955",{"facility":145,"status":76,"city":146,"state":147,"zip":148,"country":80,"countryCode":81,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Providence Cancer Institute, Franz Clinic - Eastside ( Site 0107)","Portland","Oregon","97213",{"type":83,"coordinates":150},[151,152],-122.67621,45.52345,{"lat":152,"lon":151},[155],{"name":90,"role":70,"phone":156,"phoneExt":52,"email":52},"503-215-5696",{"facility":158,"status":76,"city":159,"state":160,"zip":161,"country":80,"countryCode":81,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Avera Cancer Institute- Research ( Site 0104)","Sioux Falls","South Dakota","57105",{"type":83,"coordinates":163},[164,165],-96.72796,43.54369,{"lat":165,"lon":164},[168],{"name":90,"role":70,"phone":169,"phoneExt":52,"email":52},"605-322-6900",{"facility":171,"status":76,"city":172,"state":173,"zip":174,"country":80,"countryCode":81,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"The University of Tennessee Medical Center ( Site 0120)","Knoxville","Tennessee","37920",{"type":83,"coordinates":176},[177,178],-83.92074,35.96064,{"lat":178,"lon":177},[181],{"name":90,"role":70,"phone":182,"phoneExt":52,"email":52},"865-305-8780",{"facility":184,"status":76,"city":185,"state":173,"zip":186,"country":80,"countryCode":81,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"Lt. 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Luke Weathers, Jr. VA Medical Center ( Site 0133)","Memphis","38105",{"type":83,"coordinates":188},[189,190],-90.04898,35.14953,{"lat":190,"lon":189},[193],{"name":90,"role":70,"phone":194,"phoneExt":52,"email":52},"901-351-3673",{"facility":196,"status":76,"city":197,"state":173,"zip":198,"country":80,"countryCode":81,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"SCRI Oncology Partners ( Site 7000)","Nashville","37203",{"type":83,"coordinates":200},[201,202],-86.78444,36.16589,{"lat":202,"lon":201},[205],{"name":90,"role":70,"phone":206,"phoneExt":52,"email":52},"844-482-4812",{"facility":208,"status":76,"city":209,"state":210,"zip":211,"country":80,"countryCode":81,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"Houston Methodist Hospital - Houston Methodist Neal Cancer Center ( Site 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Santiago","7500921","Chile","CL",{"type":83,"coordinates":263},[264,265],-70.64827,-33.45694,{"lat":265,"lon":264},[268],{"name":90,"role":70,"phone":269,"phoneExt":52,"email":52},"56224205098",{"facility":271,"status":76,"city":257,"state":258,"zip":272,"country":260,"countryCode":261,"cosmosGeoPoint":273,"geoPoint":275,"contacts":276},"Pontificia Universidad Catolica de Chile ( Site 0202)","8330032",{"type":83,"coordinates":274},[264,265],{"lat":265,"lon":264},[277],{"name":90,"role":70,"phone":278,"phoneExt":52,"email":52},"+56934271024",{"facility":280,"status":76,"city":257,"state":258,"zip":281,"country":260,"countryCode":261,"cosmosGeoPoint":282,"geoPoint":284,"contacts":285},"Bradfordhill ( Site 0201)","8420383",{"type":83,"coordinates":283},[264,265],{"lat":265,"lon":264},[286],{"name":90,"role":70,"phone":287,"phoneExt":52,"email":52},"56229490970",{"facility":289,"status":76,"city":290,"state":291,"zip":292,"country":293,"countryCode":294,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"Beijing Cancer Hospital ( Site 1604)","Beijing","Beijing Municipality","100142","China","CN",{"type":83,"coordinates":296},[297,298],116.39723,39.9075,{"lat":298,"lon":297},[301],{"name":90,"role":70,"phone":302,"phoneExt":52,"email":52},"010-88121122",{"facility":304,"status":76,"city":305,"state":306,"zip":307,"country":293,"countryCode":294,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Southern Medical University Nanfang Hospital ( Site 1608)","Guangzhou","Guangdong","510515",{"type":83,"coordinates":309},[310,311],113.25,23.11667,{"lat":311,"lon":310},[314],{"name":90,"role":70,"phone":315,"phoneExt":52,"email":52},"+86 13632102245",{"facility":317,"status":76,"city":318,"state":306,"zip":319,"country":293,"countryCode":294,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Jiangmen Central Hospital ( Site 1611)","Jiangmen","529000",{"type":83,"coordinates":321},[322,323],113.08333,22.58333,{"lat":323,"lon":322},[326],{"name":90,"role":70,"phone":327,"phoneExt":52,"email":52},"+86 13702282382",{"facility":329,"status":76,"city":330,"state":331,"zip":332,"country":293,"countryCode":294,"cosmosGeoPoint":333,"geoPoint":337,"contacts":338},"The First Affiliated Hospital of Nanchang University ( Site 1610)","Nanchang","Jiangxi","330209",{"type":83,"coordinates":334},[335,336],115.85306,28.68396,{"lat":336,"lon":335},[339],{"name":90,"role":70,"phone":340,"phoneExt":52,"email":52},"+86079186319453",{"facility":342,"status":76,"city":343,"state":344,"zip":345,"country":293,"countryCode":294,"cosmosGeoPoint":346,"geoPoint":350,"contacts":351},"Shanghai East Hospital ( Site 1600)","Shanghai","Shanghai Municipality","200000",{"type":83,"coordinates":347},[348,349],121.45806,31.22222,{"lat":349,"lon":348},[352],{"name":90,"role":70,"phone":353,"phoneExt":52,"email":52},"021-20334534",{"facility":355,"status":76,"city":356,"state":357,"zip":358,"country":293,"countryCode":294,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"Sichuan Cancer hospital. ( Site 1609)","Chengdu","Sichuan","610213",{"type":83,"coordinates":360},[361,362],104.06667,30.66667,{"lat":362,"lon":361},[365],{"name":90,"role":70,"phone":366,"phoneExt":52,"email":52},"18180900912",{"facility":368,"status":76,"city":369,"state":370,"zip":371,"country":293,"countryCode":294,"cosmosGeoPoint":372,"geoPoint":376,"contacts":377},"The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 1602)","Hangzhou","Zhejiang","310003",{"type":83,"coordinates":373},[374,375],120.16142,30.29365,{"lat":375,"lon":374},[378],{"name":90,"role":70,"phone":379,"phoneExt":52,"email":52},"+8657187236560",{"facility":381,"status":76,"city":382,"state":370,"zip":383,"country":293,"countryCode":294,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"Taizhou Hospital of Zhejiang Province ( Site 1601)","Taizhou","317000",{"type":83,"coordinates":385},[386,387],121.43312,28.66266,{"lat":387,"lon":386},[390],{"name":90,"role":70,"phone":391,"phoneExt":52,"email":52},"0576-85199810",{"facility":393,"status":76,"city":394,"state":52,"zip":395,"country":396,"countryCode":397,"cosmosGeoPoint":398,"geoPoint":402,"contacts":403},"Rambam Health Care Campus ( Site 0602)","Haifa","3109601","Israel","IL",{"type":83,"coordinates":399},[400,401],34.99928,32.81303,{"lat":401,"lon":400},[404],{"name":90,"role":70,"phone":405,"phoneExt":52,"email":52},"+97247772688",{"facility":407,"status":76,"city":408,"state":52,"zip":409,"country":396,"countryCode":397,"cosmosGeoPoint":410,"geoPoint":414,"contacts":415},"Sheba Medical Center ( Site 0601)","Ramat Gan","5265601",{"type":83,"coordinates":411},[412,413],34.81065,32.08227,{"lat":413,"lon":412},[416],{"name":90,"role":70,"phone":417,"phoneExt":52,"email":52},"+97235303030",{"facility":419,"status":76,"city":420,"state":52,"zip":421,"country":422,"countryCode":52,"cosmosGeoPoint":423,"geoPoint":427,"contacts":428},"Seoul National University Hospital ( Site 1402)","Seoul","03080","South Korea",{"type":83,"coordinates":424},[425,426],126.9784,37.566,{"lat":426,"lon":425},[429],{"name":90,"role":70,"phone":430,"phoneExt":52,"email":52},"82-2-2072-3559",{"facility":432,"status":76,"city":420,"state":52,"zip":433,"country":422,"countryCode":52,"cosmosGeoPoint":434,"geoPoint":436,"contacts":437},"Severance Hospital Yonsei University Health System ( Site 1403)","03722",{"type":83,"coordinates":435},[425,426],{"lat":426,"lon":425},[438],{"name":90,"role":70,"phone":439,"phoneExt":52,"email":52},"+82215991004",{"facility":441,"status":76,"city":420,"state":52,"zip":442,"country":422,"countryCode":52,"cosmosGeoPoint":443,"geoPoint":445,"contacts":446},"Asan Medical Center ( Site 1404)","05505",{"type":83,"coordinates":444},[425,426],{"lat":426,"lon":425},[447],{"name":90,"role":70,"phone":448,"phoneExt":52,"email":52},"+82230103215",{"facility":450,"status":76,"city":420,"state":52,"zip":451,"country":422,"countryCode":52,"cosmosGeoPoint":452,"geoPoint":454,"contacts":455},"Samsung Medical Center ( Site 1401)","06351",{"type":83,"coordinates":453},[425,426],{"lat":426,"lon":425},[456],{"name":90,"role":70,"phone":457,"phoneExt":52,"email":52},"02-3410-1795",{"facility":459,"status":76,"city":460,"state":461,"zip":462,"country":463,"countryCode":464,"cosmosGeoPoint":465,"geoPoint":469,"contacts":470},"Hospital Universitario Insular de Gran Canaria ( Site 1002)","Las Palmas de Gran Canaria","Las Palmas","35016","Spain","ES",{"type":83,"coordinates":466},[467,468],-15.41573,28.10178,{"lat":468,"lon":467},[471],{"name":90,"role":70,"phone":472,"phoneExt":52,"email":52},"+34 928441738",{"type":474,"investigatorFullName":52,"investigatorTitle":52,"investigatorAffiliation":52,"oldNameTitle":52,"oldOrganization":52},"SPONSOR",[476],{"name":477,"class":6},"Daiichi Sankyo","100610439",false,"NCT07227597","A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)","A Phase 1b\u002F2 Open-label Study Evaluating Different MK-6070 and Ifinatamab Deruxtecan (MK-2400)-Based Regimens in First-line Extensive Stage Small Cell Lung Cancer","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has a histologically or cytologically confirmed diagnosis of extensive-stage small cell lung cancer (ES-SCLC)\n* For participants receiving gocatamig + ifinatamab deruxtecan (I-DXd) in maintenance only:\n\n  * Completed 3 to 4 cycles of platinum + etoposide chemotherapy with concurrent approved anti-programmed cell death 1\u002FLigand 1 (anti PD-1\u002FL1) as first line (1L) treatment of ES-SCLC within 6 weeks prior to enrollment\n  * No radiological disease progression per Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1)\n  * No other prior systemic ES-SCLC therapy allowed\n  * Rechallenge therapy counts as an additional line and leads to exclusion\n* For participants receiving gocatamig + I-DXd in induction and maintenance, or gocatamig + I-DXd in induction followed by gocatamig + atezolizumab in maintenance, or carboplatin + etoposide + atezolizumab in induction followed by atezolizumab in maintenance: No prior systemic ES-SCLC treatment allowed\n* Applicable to all participants: prior limited-stage small cell lung cancer (SCLC) is allowed if \\> 6 months have passed since the end of previous therapy and progression\n* Must be able to provide a pretreatment archival tumor tissue sample or newly obtained core, incisional, or excisional biopsy of a tumor lesion not previously irradiated\n* Measurable disease by RECIST 1.1 as assessed by the local site investigator\u002Fradiology. Lesions situated in a previously irradiated area are considered measurable if growth has been shown in such lesions since the completion of radiation\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures\n* Has any history of interstitial lung disease (ILD)\u002Fpneumonitis irrespective of steroid use, current ILD, ILD that cannot be ruled out by imaging at screening, or suspected ILD\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses\n* Has history of clinically significant intracranial bleeding or spinal cord bleeding\n* Has active neurologic paraneoplastic syndrome\n* Has history of coronary\u002Fperipheral artery bypass graft and\u002For any coronary\u002Fperipheral angioplasty or clinically significant cardiovascular disease such as myocardial infarction, symptomatic congestive heart failure (CHF), and\u002For uncontrolled cardiac arrhythmia within 6 months before the first dose of study intervention\n* Has other uncontrolled or significant protocol specified cardiovascular disease\n* Has history of arterial thrombosis within 6 months before the first dose of study intervention\n* Has chronic liver disease\n* Has history of allogeneic tissue\u002Fsolid organ transplant\n* Has history of leptomeningeal disease\n* Is infected with human immunodeficiency virus (HIV) and has a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has received prior therapy with an anti-programmed cell death protein 1 (anti-PD-1), anti-programmed cell death ligand 1 (anti-PD-L1), or anti-programmed cell death ligand 2 (anti-PD-L2) agent or with an agent directed to another stimulatory or coinhibitory T-cell receptor\n* Has received prior radiotherapy within 2 weeks of start of study intervention, or has radiation-related toxicities, requiring corticosteroids\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has active autoimmune disease that has required systemic treatment in the past 2 years except replacement therapy\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* Has major surgery within 4 weeks or minor surgery within 2 weeks of allocation\u002Frandomization (or first dose), or is anticipated to require a major surgical procedure during the study","ALL","18 Years",{"count":487,"type":488},170,"ESTIMATED","INTERVENTIONAL",[491,492],"PHASE1","PHASE2","Researchers are looking for new ways to treat extensive-stage small cell lung cancer (ES-SCLC). ES-SCLC is a type of lung cancer that has spread throughout the lung, to the other lung, or to other parts of the body.\n\nA standard (usual) treatment for ES-SCLC uses both chemotherapy and immunotherapy.\n\n* Chemotherapy is a treatment that works to destroy cancer cells or stop them from growing.\n* Immunotherapy is a treatment that helps the immune system fight cancer.\n\nGocatamig and I-DXd (short for ifinatamab deruxtecan) are study medicines. Researchers want to know if giving gocatamig and I-DXd together can treat ES-SCLC. Researchers will also look at giving the study medicines with standard treatment. Gocatamig is a T-cell engager therapy. I-DXd is an antibody drug conjugate.\n\n* T-cell engager therapy is a certain type of immunotherapy that uses T-cells to find and destroy cancer cells.\n* A T-cell is a type of white blood cell, which are cells that help the body fight infection.\n* An antibody drug conjugate (ADC) is a treatment that attaches to a protein on cancer cells and delivers treatment to destroy those cells.\n\nThe goals of this study are to learn:\n\n* About the safety of combining gocatamig and I-DXd and if people tolerate them together\n* If people who receive gocatamig and I-DXd have ES-SCLC respond, which means the cancer gets smaller or goes away",[495],"Small Cell Lung Cancer Extensive Stage","2026-06-24",{"date":498,"type":499},"2026-06-26","ACTUAL",{"date":501,"type":499},"2026-01-29",{"date":503,"type":488},"2030-12-30",{"name":5,"class":6},32]