[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614942":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":60,"centralContacts":64,"locations":70,"responsibleParty":368,"collaborators":370,"id":373,"slug":374,"hasResults":375,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":32,"eligibilityCriteria":379,"healthyVolunteers":375,"sex":380,"minAge":381,"maxAge":32,"enrollmentInfo":382,"targetDuration":32,"studyType":385,"phases":386,"briefSummary":389,"conditions":390,"keywords":32,"overallStatus":73,"whyStopped":32,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":401},{"fullName":5,"class":6},"Merck Sharp & Dohme LLC","INDUSTRY",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"MK-1084 + Patritumab deruxtecan (HER3-DXd)","EXPERIMENTAL","Participants will receive MK-1084 and HER3-DXd until discontinuation due to toxicity, adverse event (AE) or at the discretion of an investigator.",[13,14],"Drug: MK-1084","Biological: Patritumab deruxtecan",{"label":16,"type":10,"description":17,"interventionNames":18},"MK-1084 + Sacituzumab tirumotecan (Sac-TMT)","Participants will receive MK-1084 and sac-TMT until discontinuation due to toxicity, AE or at the discretion of an investigator.",[13,19,20],"Biological: Sacituzumab tirumotecan","Drug: Rescue Medications",{"label":22,"type":10,"description":23,"interventionNames":24},"MK-1084 + Cetuximab","Participants will receive MK-1084 and cetuximab until discontinuation due to toxicity, AE or at the discretion of an investigator.",[13,25],"Biological: Cetuximab",[27,33,42,50,56],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","MK-1084","Oral administration",[22,9,16],null,{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"BIOLOGICAL","Patritumab deruxtecan","IV infusion",[9],[39,40,41],"HER3-DXd","MK-1022","U3-1402",{"type":34,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"Sacituzumab tirumotecan","IV Infusion",[16],[47,48,49],"Sac-TMT","MK-2870","SKB264",{"type":34,"name":51,"description":44,"armGroupLabels":52,"otherNames":53},"Cetuximab",[22],[54,55],"C225","Erbitux",{"type":28,"name":57,"description":58,"armGroupLabels":59,"otherNames":32},"Rescue Medications","Participants receive rescue medication at the investigator's discretion, per approved product label. Recommended rescue medications are histamine -1 (H1) receptor agonist, histamine-2 (H2) receptor antagonist, acetaminophen or equivalent, dexamethasone or equivalent infusion, or steroid mouthwash (dexamethasone or equivalent) for prevention of chemotherapy induced nausea and vomiting.",[16],[61],{"name":62,"affiliation":5,"role":63},"Medical Director","STUDY_DIRECTOR",[65],{"name":66,"role":67,"phone":68,"phoneExt":32,"email":69},"Toll Free Toll Free Number","CONTACT","1-888-577-8839","Trialsites@msd.com",[71,89,102,115,123,138,151,163,174,189,198,207,222,237,246,259,270,281,295,307,322,335,345,356],{"facility":72,"status":73,"city":74,"state":75,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"Clermont Oncology Center ( Site 0041)","RECRUITING","Clermont","Florida","34711","United States","US",{"type":80,"coordinates":81},"Point",[82,83],-81.77285,28.54944,{"lat":83,"lon":82},[86],{"name":87,"role":67,"phone":88,"phoneExt":32,"email":32},"Study Coordinator","386-538-3169",{"facility":90,"status":73,"city":91,"state":92,"zip":93,"country":77,"countryCode":78,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"University of Illinois Hospital & Health Sciences System ( Site 0044)","Chicago","Illinois","60612",{"type":80,"coordinates":95},[96,97],-87.65005,41.85003,{"lat":97,"lon":96},[100],{"name":87,"role":67,"phone":101,"phoneExt":32,"email":32},"312-996-9272",{"facility":103,"status":73,"city":104,"state":105,"zip":106,"country":77,"countryCode":78,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Providence Portland Medical Center ( Site 0043)","Portland","Oregon","97213",{"type":80,"coordinates":108},[109,110],-122.67621,45.52345,{"lat":110,"lon":109},[113],{"name":87,"role":67,"phone":114,"phoneExt":32,"email":32},"503-215-1979",{"facility":116,"status":73,"city":104,"state":105,"zip":117,"country":77,"countryCode":78,"cosmosGeoPoint":118,"geoPoint":120,"contacts":121},"Providence Oncology and Hematology Care Clinic - 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( Site 0205)","115 28",{"type":80,"coordinates":241},[231,232],{"lat":232,"lon":231},[244],{"name":87,"role":67,"phone":245,"phoneExt":32,"email":32},"+302132162543",{"facility":247,"status":73,"city":248,"state":32,"zip":249,"country":248,"countryCode":250,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Queen Mary Hospital ( Site 0230)","Hong Kong","000000","HK",{"type":80,"coordinates":252},[253,254],114.17469,22.27832,{"lat":254,"lon":253},[257],{"name":87,"role":67,"phone":258,"phoneExt":32,"email":32},"+85222551727",{"facility":260,"status":73,"city":261,"state":32,"zip":249,"country":248,"countryCode":250,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"Hong Kong United Oncology Centre ( Site 0232)","Jordan",{"type":80,"coordinates":263},[264,265],114.17001,22.30539,{"lat":265,"lon":264},[268],{"name":87,"role":67,"phone":269,"phoneExt":32,"email":32},"+852 5508 7858",{"facility":271,"status":73,"city":272,"state":32,"zip":32,"country":248,"countryCode":250,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"Prince of Wales Hospital ( Site 0231)","Shatin",{"type":80,"coordinates":274},[275,276],114.18333,22.38333,{"lat":276,"lon":275},[279],{"name":87,"role":67,"phone":280,"phoneExt":32,"email":32},"+852 3505 1202",{"facility":282,"status":73,"city":283,"state":32,"zip":284,"country":285,"countryCode":286,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"Shaare Zedek Medical Center ( Site 0186)","Jerusalem","9103102","Israel","IL",{"type":80,"coordinates":288},[289,290],35.21633,31.76904,{"lat":290,"lon":289},[293],{"name":87,"role":67,"phone":294,"phoneExt":32,"email":32},"+97226555999",{"facility":296,"status":73,"city":297,"state":32,"zip":298,"country":285,"countryCode":286,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Sheba Medical Center ( Site 0180)","Ramat Gan","5265601",{"type":80,"coordinates":300},[301,302],34.81065,32.08227,{"lat":302,"lon":301},[305],{"name":87,"role":67,"phone":306,"phoneExt":32,"email":32},"+97235303030",{"facility":308,"status":73,"city":309,"state":310,"zip":311,"country":312,"countryCode":313,"cosmosGeoPoint":314,"geoPoint":318,"contacts":319},"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\" ( Site 0176)","Meldola","Forli-Cesena","47014","Italy","IT",{"type":80,"coordinates":315},[316,317],12.0626,44.12775,{"lat":317,"lon":316},[320],{"name":87,"role":67,"phone":321,"phoneExt":32,"email":32},"393487469100",{"facility":323,"status":73,"city":324,"state":32,"zip":325,"country":326,"countryCode":32,"cosmosGeoPoint":327,"geoPoint":331,"contacts":332},"Severance Hospital, Yonsei University Health System ( Site 0080)","Seoul","03722","South Korea",{"type":80,"coordinates":328},[329,330],126.9784,37.566,{"lat":330,"lon":329},[333],{"name":87,"role":67,"phone":334,"phoneExt":32,"email":32},"+82222280880",{"facility":336,"status":73,"city":337,"state":338,"zip":339,"country":340,"countryCode":341,"cosmosGeoPoint":32,"geoPoint":32,"contacts":342},"Institut Català d'Oncologia - L'Hospitalet ( Site 0090)","Hospitalet","Barcelona","08908","Spain","ES",[343],{"name":87,"role":67,"phone":344,"phoneExt":32,"email":32},"0034932607744",{"facility":346,"status":73,"city":338,"state":32,"zip":347,"country":340,"countryCode":341,"cosmosGeoPoint":348,"geoPoint":352,"contacts":353},"Hospital Clinic de Barcelona ( Site 0092)","08036",{"type":80,"coordinates":349},[350,351],2.15899,41.38879,{"lat":351,"lon":350},[354],{"name":87,"role":67,"phone":355,"phoneExt":32,"email":32},"34 932275402",{"facility":357,"status":73,"city":358,"state":32,"zip":359,"country":340,"countryCode":341,"cosmosGeoPoint":360,"geoPoint":364,"contacts":365},"Hospital Universitario Virgen Macarena ( Site 0093)","Seville","41009",{"type":80,"coordinates":361},[362,363],-5.97317,37.38283,{"lat":363,"lon":362},[366],{"name":87,"role":67,"phone":367,"phoneExt":32,"email":32},"+34 671560092",{"type":369,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[371],{"name":372,"class":6},"Daiichi Sankyo","100614942","phase-1-a-clinical-study-of-mk-1084-with-other-treatments-for-non-small-cell-lung-cancer-mk-3475-01f-100614942",false,"NCT07286149","A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)","KEYMAKER-U01 Substudy 01F: A Phase 1b\u002F2 Umbrella Study With Rolling Arms of Investigational Agents for Previously Treated Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With KRAS G12C Mutations","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has histologically or cytologically confirmed diagnosis of advanced or metastatic non-squamous non-small cell lung cancer (NSCLC)\n* Has tumor tissue or circulating tumor deoxyribonucleic acid (ctDNA) that demonstrates the presence of Kirsten rat sarcoma viral oncogene (KRAS) mutation of glycine to cysteine at codon 12 (G12C) mutations\n* Has documented disease progression after receiving 1-2 prior lines of programmed cell death protein 1 (PD-1)\u002Fprogrammed death-ligand 1 (PD-L1) therapy and platinum-based chemotherapy\n* Provides archival tumor tissue sample of a tumor lesion not previously irradiated\n* Has provided tissue prior to treatment allocation\u002Frandomization from a newly obtained biopsy of a tumor lesion not previously irradiated\n* Participants with human immunodeficiency virus (HIV) infection must have well-controlled HIV on antiretroviral therapy (ART) per protocol\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has a diagnosis of small cell lung cancer or, for mixed tumors, presence of small cell elements\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease\n* Has evidence of any leptomeningeal disease\n* Has uncontrolled or significant cardiovascular disorder or cerebrovascular disease prior to allocation\u002Frandomization\n* Has one or more of the following ophthalmological conditions: a) Clinically significant corneal disease b) history of documented severe dry eye syndrome, severe Meibomian gland disease and\u002For blepharitis\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has received previous treatment with an agent targeting KRAS\n* Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention\n* Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study intervention\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has history of (noninfectious) pneumonitis\u002F interstitial lung disease (ILD) that required steroids or has current pneumonitis\u002FILD\n* Has an active infection requiring systemic therapy\n* Have not adequately recovered from major surgery or have ongoing surgical complications","ALL","18 Years",{"count":383,"type":384},190,"ESTIMATED","INTERVENTIONAL",[387,388],"PHASE1","PHASE2","Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread. The goals of this study are to learn:\n\n* About the safety of MK-1084 and if people tolerate it when taken with other treatments\n* How many people have the cancer respond (get smaller or go away) to the treatments",[391],"Lung Neoplasm Malignant","2026-06-16",{"date":394,"type":395},"2026-06-18","ACTUAL",{"date":397,"type":395},"2026-04-30",{"date":399,"type":384},"2032-04-13",{"name":5,"class":6},24]