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Efficacy of MK-2870 Monotherapy or in Combination With Other Anticancer Agents in Gastrointestinal Cancers","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has one of the following cancers:\n\n  * Unresectable or metastatic colorectal cancer and has received prior therapy for the cancer\n  * Advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) and has received prior therapy for the cancer\n  * Advanced and\u002For unresectable biliary tract cancer (BTC) and has received prior therapy for the cancer\n  * Advanced and\u002For unresectable BTC and has not received prior therapy for the cancer\n* For participants who have received prior therapy for cancer: Has recovered from any side effects due to previous cancer treatment\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* History of severe eye disease\n* For participants who have received prior therapy for cancer: Received prior systemic anticancer therapy including investigational agents within 4 weeks before starting study intervention\n* History of (noninfectious) pneumonitis\u002Finterstitial lung disease (ILD) that required steroids, has current pneumonitis\u002FILD, or has suspected ILD or pneumonitis that cannot be ruled out by standard diagnostic assessments at Screening","ALL","18 Years",{"count":761,"type":762},220,"ESTIMATED","INTERVENTIONAL",[765,766],"PHASE1","PHASE2","Researchers want to learn if sacituzumab tirumotecan (MK-2870) alone or with other treatments can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are either advanced (the cancer has spread to other parts of the body), or unresectable (the cancer cannot be removed with surgery). The goals of this study are to learn:\n\n* About the safety of sacituzumab tirumotecan alone or with other treatments and if people tolerate it\n* How many people have the cancer respond (get smaller or go away) to treatment",[769,770,771],"Colorectal Cancer","Pancreatic Ductal Adenocarcinoma","Biliary Tract Cancer","2026-06-30",{"date":774,"type":775},"2026-07-01","ACTUAL",{"date":777,"type":775},"2024-06-20",{"date":779,"type":762},"2029-10-16",{"name":5,"class":6},55]