[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603329":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":11,"locations":20,"responsibleParty":41,"collaborators":11,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":11,"eligibilityCriteria":49,"healthyVolunteers":46,"sex":50,"minAge":51,"maxAge":11,"enrollmentInfo":52,"targetDuration":11,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":11,"overallStatus":23,"whyStopped":11,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Shandong Cancer Hospital and Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"225Ac-PSMA-XT treatment","EXPERIMENTAL",null,[13],"Drug: 225Ac-PSMA-XT",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DRUG","225Ac-PSMA-XT","Patients will receive 225Ac-PSMA-XT administration at an interval of 6 weeks between each dose.",[9],[21],{"facility":22,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Cancer Hospital of Shandong First Medical University","RECRUITING","Jinan","Shandong","100023","China","CN",{"type":30,"coordinates":31},"Point",[32,33],116.99722,36.66833,{"lat":33,"lon":32},[36],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Xiaorong Sun","CONTACT","0531-67626287","xrsun@sdfmu.edu.cn",{"type":42,"investigatorFullName":37,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Director of Nuclear Medicine Department","100603329","phase-1-a-clinical-study-to-evaluate-the-safety-tolerability-and-preliminary-efficacy-of-225acac-psma-xt-injection-in-patients-with-metastatic-castration-resistant-prostate-cancer-100603329",false,"NCT07135102","A Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of [225Ac]Ac-PSMA-XT Injection in Patients With Metastatic Castration-resistant Prostate Cancer","Inclusion Criteria:\n\n1. have the ability to understand and sign an approved informed consent form (ICF).\n2. \\>= 18 years old.\n3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n4. have a life expectancy \\>6 months.\n5. have histological, pathological, and\u002For cytological confirmation of prostate cancer.\n6. PSMA Positron Emission Tomography (PET)\u002FComputed Tomography (CT) scan positive\n7. have a castrate level of serum\u002Fplasma testosterone (\\\u003C50 ng\u002FdL or \\\u003C1.7 nmol\u002FL).\n8. have received at least one NAAD (such as enzalutamide and\u002For abiraterone)； patients must have been previously treated undergone at least 1-2 prior taxane-based chemotherapy regimens or be unsuitable for taxane therapy (unsuitability includes contraindications, investigator-determined ineligibility, or patient refusal) in mCRPC stage.\n9. progressive mCRPC.\n10. have adequate organ function。\n11. Subjects of childbearing potential voluntarily use an effective method of contraception, such as condoms, oral or injectable contraceptives, Intra-uterine device（IUD）,etc., during treatment and within 6 months of the last use of the trial drug.\n\nExclusion Criteria:\n\n1. Previous treatment with any of the following within 6 months of enrollment: Strontium-89, Samarium-153, Rhenium-186, Rhenium-188, Radium-223, hemi-body irradiation. Previous PSMA-targeted radioligand therapy is not allowed.\n\n   Known other malignancies.\n2. Any systemic anti-cancer therapy (e.g. chemotherapy, immunotherapy or biological therapy within 28 days prior to day of enrollment.\n3. Known hypersensitivity to the components of the study therapy or its analogs.\n4. A superscan as seen in the baseline bone scan.\n5. Patients with a history of Central Nervous System (CNS) metastases.\n6. Uncontrolled, intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, cardiac arrhythmia, or other severe complications.","MALE","18 Years",{"count":53,"type":54},40,"ESTIMATED","INTERVENTIONAL",[57],"PHASE1","The purpose of this study is to determine the safety and efficacy of 225Ac -labeled PSMA ligand(PSMA-XT) in the treatment of mCRPC",[60],"Metastatic Castration-Resistant Prostate Cancer Patients","2025-08-21",{"date":63,"type":64},"2025-08-24","ACTUAL",{"date":66,"type":64},"2024-10-14",{"date":68,"type":54},"2027-06-01",{"name":37,"class":6},1]