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Fe","Valencia","46026",{"type":76,"coordinates":688},[689,690],-0.37966,39.47391,{"lat":690,"lon":689},{"facility":693,"status":69,"city":694,"state":54,"zip":695,"country":696,"countryCode":697,"cosmosGeoPoint":698,"geoPoint":702,"contacts":54},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City","807","Taiwan","TW",{"type":76,"coordinates":699},[700,701],120.31333,22.61626,{"lat":701,"lon":700},{"facility":704,"status":69,"city":705,"state":54,"zip":706,"country":696,"countryCode":697,"cosmosGeoPoint":707,"geoPoint":711,"contacts":54},"Taichung Veterans General Hospital","Taichung","40705",{"type":76,"coordinates":708},[709,710],120.6839,24.1469,{"lat":710,"lon":709},{"facility":713,"status":69,"city":714,"state":54,"zip":715,"country":696,"countryCode":697,"cosmosGeoPoint":716,"geoPoint":720,"contacts":54},"National Cheng Kung University Hospital","Tainan","704",{"type":76,"coordinates":717},[718,719],120.21333,22.99083,{"lat":719,"lon":718},{"facility":722,"status":69,"city":723,"state":54,"zip":724,"country":696,"countryCode":697,"cosmosGeoPoint":725,"geoPoint":729,"contacts":54},"National Taiwan University Cancer Center","Taipei","106",{"type":76,"coordinates":726},[727,728],121.52639,25.05306,{"lat":728,"lon":727},{"facility":731,"status":69,"city":723,"state":54,"zip":732,"country":696,"countryCode":697,"cosmosGeoPoint":733,"geoPoint":735,"contacts":54},"Taipei Veterans General Hospital","11217",{"type":76,"coordinates":734},[727,728],{"lat":728,"lon":727},{"facility":737,"status":69,"city":738,"state":54,"zip":739,"country":740,"countryCode":54,"cosmosGeoPoint":741,"geoPoint":745,"contacts":54},"Adana City Hospital","Adana","01230","Turkey (Türkiye)",{"type":76,"coordinates":742},[743,744],35.32531,36.98615,{"lat":744,"lon":743},{"facility":747,"status":69,"city":748,"state":54,"zip":749,"country":740,"countryCode":54,"cosmosGeoPoint":750,"geoPoint":754,"contacts":54},"Hacettepe University Medical Faculty","Ankara","06100",{"type":76,"coordinates":751},[752,753],32.85427,39.91987,{"lat":753,"lon":752},{"facility":756,"status":69,"city":748,"state":54,"zip":757,"country":740,"countryCode":54,"cosmosGeoPoint":758,"geoPoint":760,"contacts":54},"Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital","06105",{"type":76,"coordinates":759},[752,753],{"lat":753,"lon":752},{"facility":762,"status":69,"city":748,"state":54,"zip":763,"country":740,"countryCode":54,"cosmosGeoPoint":764,"geoPoint":766,"contacts":54},"Ankara City Hospital","06800",{"type":76,"coordinates":765},[752,753],{"lat":753,"lon":752},{"facility":768,"status":69,"city":769,"state":54,"zip":770,"country":740,"countryCode":54,"cosmosGeoPoint":771,"geoPoint":775,"contacts":54},"Yeditepe University Medical School Hospital","Istanbul","31755",{"type":76,"coordinates":772},[773,774],28.94966,41.01384,{"lat":774,"lon":773},{"facility":777,"status":69,"city":769,"state":54,"zip":778,"country":740,"countryCode":54,"cosmosGeoPoint":779,"geoPoint":781,"contacts":54},"Koc University Hospital","34010",{"type":76,"coordinates":780},[773,774],{"lat":774,"lon":773},{"facility":783,"status":69,"city":784,"state":54,"zip":785,"country":740,"countryCode":54,"cosmosGeoPoint":786,"geoPoint":790,"contacts":54},"Sakarya Training and Research Hospital","Sakarya","54187",{"type":76,"coordinates":787},[788,789],32.07583,39.50333,{"lat":789,"lon":788},{"facility":792,"status":69,"city":793,"state":54,"zip":794,"country":795,"countryCode":796,"cosmosGeoPoint":797,"geoPoint":801,"contacts":54},"Bristol Haematology and Oncology Centre","Bristol","BS2 8ED","United Kingdom","UK",{"type":76,"coordinates":798},[799,800],-2.59665,51.45523,{"lat":800,"lon":799},{"facility":803,"status":69,"city":804,"state":54,"zip":805,"country":795,"countryCode":796,"cosmosGeoPoint":806,"geoPoint":810,"contacts":54},"St. James's University Hospital","Leeds","LS97TF",{"type":76,"coordinates":807},[808,809],-1.54785,53.79648,{"lat":809,"lon":808},{"facility":812,"status":69,"city":813,"state":54,"zip":814,"country":795,"countryCode":796,"cosmosGeoPoint":815,"geoPoint":819,"contacts":54},"The Clatterbridge Cancer Center","Liverpool","L7 8YA",{"type":76,"coordinates":816},[817,818],-2.97794,53.41058,{"lat":818,"lon":817},{"facility":821,"status":69,"city":822,"state":54,"zip":823,"country":795,"countryCode":796,"cosmosGeoPoint":824,"geoPoint":828,"contacts":54},"St George's Hospitals NHS Foundation Trust","London","SW170QT",{"type":76,"coordinates":825},[826,827],-0.12574,51.50853,{"lat":827,"lon":826},{"facility":830,"status":69,"city":822,"state":54,"zip":831,"country":795,"countryCode":796,"cosmosGeoPoint":832,"geoPoint":834,"contacts":54},"University College London Hospital","W1T 7HA",{"type":76,"coordinates":833},[826,827],{"lat":827,"lon":826},{"facility":836,"status":69,"city":837,"state":54,"zip":838,"country":795,"countryCode":796,"cosmosGeoPoint":839,"geoPoint":843,"contacts":54},"The Christie NHS Foundation Trust","Manchester","M204BX",{"type":76,"coordinates":840},[841,842],-2.23743,53.48095,{"lat":842,"lon":841},{"type":845,"investigatorFullName":54,"investigatorTitle":54,"investigatorAffiliation":54,"oldNameTitle":54,"oldOrganization":54},"SPONSOR",[847,849],{"name":848,"class":6},"DualityBio Inc.",{"name":850,"class":6},"Biotheus Inc.","100584684","phase-1-a-clinical-study-to-investigate-the-efficacy-and-safety-of-an-investigational-combination-therapy-with-bnt324-and-bnt327-in-patients-with-advanced-lung-cancer-100584684",false,"NCT06892548","A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer","A Phase Ib\u002FII, Multi-site, Open-label, Two-part Trial to Evaluate the Efficacy, Safety, Pharmacokinetics, and Recommended Combination Dose of BNT324 With BNT327 in Participants With Advanced Lung Cancer","Inclusion Criteria:\n\n* Aged ≥18 years at the time of giving informed consent.\n* Histological or cytological confirmed unresectable advanced\u002Fmetastatic lung cancer. Histological classification may be based on tumor samples prior to metastatic disease. Participants with mixed histology must be classified based on the main component. Participants with NSCLC are eligible with any or no PD-L1 expression. Participants with AGA-positive disease must have received targeted therapy prior to enrollment in this study.\n\n  * Part 1: Participants with NSCLC and SCLC\n  * Part 2 Cohort 1: Participants with NSCLC (subpopulation 1) AGA negative, 1L\n  * Part 2 Cohort 2: Participants with SCLC, 2L+\n  * Part 2 Cohort 3: Participants with NSCLC (subpopulation 1) AGA negative, 2L+\n  * Part 2 Cohort 4: Participants with NSCLC (subpopulation 2) AGA negative, 1L\n  * Part 2 Cohort 5: Participants with NSCLC (subpopulation 2) AGA negative, 2L+\n  * Part 2 Cohort 6: Participants with NSCLC AGA positive\n  * Part 2 Cohort 7: Participants with SCLC, 1L\n* Have measurable disease defined by RECIST version 1.1.\n* Have an Eastern Cooperative Oncology Group performance status of 0 or 1.\n* Have a life expectancy of ≥12 weeks.\n\nExclusion Criteria:\n\n* Prior treatment with B7-H3 targeted therapy.\n* Prior treatment with ADC with topoisomerase inhibitor (e.g., datopotamab deruxtecan, trastuzumab deruxtecan). Note: This exclusion applies to participants in the first-line\u002Ftreatment-naïve cohorts in the advanced\u002Fmetastatic setting. Prior treatment with ADC with topoisomerase inhibitor payload is only allowed for participants in the second-line plus cohorts in the advanced\u002Fmetastatic setting.\n* Is a candidate to locoregional treatment (including surgical resection, stereotactic radiotherapy or tumor ablation) with potential to induce complete or near complete response and prolonged tumor control (sometimes described as \"radical\" intent), per investigator's assessment.\n* Has a history of significant hematologic toxicity to prior lines of therapy, as assessed by investigator, e.g., Grade 4 febrile neutropenia or recurrent\u002Fpersistent Grade 3 to 4 neutropenia.\n\nNOTE: Other protocol defined Inclusion\u002FExclusion criteria may apply to all or some participants depending on the cohort.","ALL","18 Years",{"count":861,"type":862},594,"ESTIMATED","INTERVENTIONAL",[865,866],"PHASE1","PHASE2","This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced\u002Fmetastatic or relapsed\u002Fprogressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).",[869],"Advanced Lung Cancer",[871,872,873,874,875,876,52,877,878,879,880],"Small cell lung cancer (SCLC)","Non-small cell lung cancer (NSCLC)","Programmed death-ligand 1 (PD-L1)","Vascular endothelial growth factor (VEGF)","Bispecific antibody","BNT324 (DB-1311)","Combination with chemotherapy","Combination with other investigational agents","Immunotherapy","Treatment-naïve","2026-06-23",{"date":883,"type":884},"2026-06-24","ACTUAL",{"date":886,"type":884},"2025-05-02",{"date":888,"type":862},"2032-05",{"name":5,"class":6},86]