[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641939":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":42,"centralContacts":47,"locations":11,"responsibleParty":53,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":11,"studyType":69,"phases":70,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":78,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":11},{"fullName":5,"class":6},"Genrix (Shanghai) Biopharmaceutical Co., Ltd.","INDUSTRY",[8,14,17,20,23,26,29],{"label":9,"type":10,"description":11,"interventionNames":12},"GR2301 injection dose1\u002FPlacebo","EXPERIMENTAL",null,[13],"Biological: GR2301 injection",{"label":15,"type":10,"description":11,"interventionNames":16},"GR2301 injection dose2\u002FPlacebo",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"GR2301 injection dose3\u002FPlacebo",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"GR2301 injection dose4",[13],{"label":24,"type":10,"description":11,"interventionNames":25},"GR2301 injection dose5",[13],{"label":27,"type":10,"description":11,"interventionNames":28},"GR2301 injection dose6",[13],{"label":30,"type":31,"description":11,"interventionNames":32},"Placebo","PLACEBO_COMPARATOR",[33],"Biological: Placebo",[35,40],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":11},"BIOLOGICAL","GR2301 injection","IL15 monoclonal antibody",[9,15,18,21,24,27],{"type":36,"name":30,"description":30,"armGroupLabels":41,"otherNames":11},[30],[43],{"name":44,"affiliation":45,"role":46},"Yong Cui, Ph.D","China-Japan Friendship Hospital","PRINCIPAL_INVESTIGATOR",[48],{"name":49,"role":50,"phone":51,"phoneExt":11,"email":52},"liaison officer","CONTACT","021-50805988-8039","shuxueye@genrixbio.com",{"type":54,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100641939","phase-1-a-clinical-trial-of-multiple-doses-of-gr2301-injection-combined-with-phototherapy-in-trial-participants-with-vitiligo-100641939",false,"NCT07647237","A Clinical Trial of Multiple Doses of GR2301 Injection Combined With Phototherapy in Trial Participants With Vitiligo","A Randomized, Double-blind, Placebo-controlled Phase Ib\u002FII Clinical Trial of Multiple Subcutaneous Injections of GR2301 in Combination With Phototherapy to Evaluate the Tolerability, Safety, Pharmacokinetics, and Preliminary Efficacy in Trial Participants With Vitiligo","GREVIT","Main Inclusion Criteria:\n\n1. Meet the clinical diagnosis of non-segmental vitiligo at screening visit and baseline visit, and meet the following criteria: clinical diagnosis of non-segmental vitiligo for at least 3 months at screening visit; facial affected BSA ≥0.5% and total body affected BSA ≥3% at screening visit and baseline visit; F-VASI and T-VASI scores meet the criteria at screening visit and baseline visit.\n2. Able to understand and comply with the requirements of the clinical protocol, voluntarily participate in the clinical trial, and provide signed written informed consent by the trial participant or their legally authorized representative.\n\nMain Exclusion Criteria:\n\n1. Vitiligo-related medical conditions and other dermatologic diseases\u002Fconditions.\n2. Prior permanent tattooing or grafting within the vitiligo lesions.\n3. Have absolute contraindications to phototherapy; or have relative contraindications to phototherapy (as comprehensively judged by the investigator).\n4. Are unwilling or unable to comply with the permitted and prohibited concomitant medications\u002Ftreatment specifications of this trial, and cannot meet the protocol-required washout period for medications\u002Ftreatments prior to randomization.\n5. Have a serious underlying disease that, in the investigator's opinion, may pose a safety risk to the trial participant if enrolled in the clinical trial.","ALL","18 Years","65 Years",{"count":67,"type":68},116,"ESTIMATED","INTERVENTIONAL",[71,72],"PHASE1","PHASE2","This is a randomized, double-blind, placebo-controlled Phase Ib\u002FII clinical trial of multiple subcutaneous injections of GR2301 in combination with phototherapy to evaluate the tolerability, safety, pharmacokinetics, and preliminary efficacy in trial participants with vitiligo. The trial will be conducted in two stages: a dose-escalation stage (Phase Ib) and an expansion cohort stage (Phase II).",[75],"Vitiligo",[77],"IL15","NOT_YET_RECRUITING","2026-06-09",{"date":81,"type":82},"2026-06-15","ACTUAL",{"date":84,"type":68},"2026-06",{"date":86,"type":68},"2028-12",{"name":5,"class":6}]