[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593803":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":322,"collaborators":19,"id":324,"slug":325,"hasResults":326,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":19,"eligibilityCriteria":330,"healthyVolunteers":326,"sex":331,"minAge":332,"maxAge":19,"enrollmentInfo":333,"targetDuration":19,"studyType":336,"phases":337,"briefSummary":340,"conditions":341,"keywords":19,"overallStatus":214,"whyStopped":19,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":352},{"fullName":5,"class":6},"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"TQB3909 Tablets + Azacitidine","EXPERIMENTAL","TQB3909 Tablets administered once-daily. 28 days as a treatment cycle.",[13],"Drug: TQB3909 Tablets + Azacitidine",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","TQB3909 is a protein inhibitor; Azacitidine is a cytidine nucleoside analogue",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"JianXiang Wang, Master","CONTACT","13821389157","wangjx@ihcams.ac.cn",[27,46,61,72,83,98,113,128,143,158,173,188,198,212,228,243,254,269,281,292,307],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"The First Affiliated Hospital of Bengbu Medical University","NOT_YET_RECRUITING","Bengbu","Anhui","233000","China","CN",{"type":36,"coordinates":37},"Point",[38,39],117.36083,32.94083,{"lat":39,"lon":38},[42],{"name":43,"role":23,"phone":44,"phoneExt":19,"email":45},"JunFeng Zhu, Master","15215526662","Zhujunfeng517@163.com",{"facility":47,"status":29,"city":48,"state":49,"zip":50,"country":33,"countryCode":34,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Beijing Chaoyang Hospital Affiliated to Capital Medical University","Beijing","Beijing Municipality","100020",{"type":36,"coordinates":52},[53,54],116.39723,39.9075,{"lat":54,"lon":53},[57],{"name":58,"role":23,"phone":59,"phoneExt":19,"email":60},"Wenming Chen, Doctor","13910107759","13910107759@163.com",{"facility":62,"status":29,"city":48,"state":49,"zip":63,"country":33,"countryCode":34,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Peking University People's Hospital","100044",{"type":36,"coordinates":65},[53,54],{"lat":54,"lon":53},[68],{"name":69,"role":23,"phone":70,"phoneExt":19,"email":71},"Hao Jiang, Master","13601164350","Jiangha0090@sina.com",{"facility":73,"status":29,"city":48,"state":49,"zip":74,"country":33,"countryCode":34,"cosmosGeoPoint":75,"geoPoint":77,"contacts":78},"Beijing Tsinghua Changgung Hospital","102218",{"type":36,"coordinates":76},[53,54],{"lat":54,"lon":53},[79],{"name":80,"role":23,"phone":81,"phoneExt":19,"email":82},"Lihong Li, Master","13501390152","llh1966@hotmail.com",{"facility":84,"status":29,"city":85,"state":86,"zip":87,"country":33,"countryCode":34,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Affiliated Hospital of Chengde Medical University","Chengde","Hebei","67020",{"type":36,"coordinates":89},[90,91],117.95883,40.9519,{"lat":91,"lon":90},[94],{"name":95,"role":23,"phone":96,"phoneExt":19,"email":97},"Zhihua Zhang, Master","15633142950","zzhangzhihua@163.com",{"facility":99,"status":29,"city":100,"state":101,"zip":102,"country":33,"countryCode":34,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Harbin The First Hospital","Harbin","Heilongjiang","150010",{"type":36,"coordinates":104},[105,106],126.65,45.75,{"lat":106,"lon":105},[109],{"name":110,"role":23,"phone":111,"phoneExt":19,"email":112},"Tiejun Gong, Master","13836027737","arc@sina.con",{"facility":114,"status":29,"city":115,"state":116,"zip":117,"country":33,"countryCode":34,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Henan Provincial People's Hospital","Zhengzhou","Henan","450000",{"type":36,"coordinates":119},[120,121],113.64861,34.75778,{"lat":121,"lon":120},[124],{"name":125,"role":23,"phone":126,"phoneExt":19,"email":127},"Zhen Wang, Master","13949115270","jenny1983218@126.com",{"facility":129,"status":29,"city":130,"state":131,"zip":132,"country":33,"countryCode":34,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Zhongnan Hospital of Wuhan University","Wuhan","Hubei","430071",{"type":36,"coordinates":134},[135,136],114.26667,30.58333,{"lat":136,"lon":135},[139],{"name":140,"role":23,"phone":141,"phoneExt":19,"email":142},"FULING ZHOU, Doctor","189 8626 5580","zhoufuling@163.com",{"facility":144,"status":29,"city":145,"state":146,"zip":147,"country":33,"countryCode":34,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Zhuzhou Central Hospita","Zhuzhou","Hunan","412007",{"type":36,"coordinates":149},[150,151],113.15,27.83333,{"lat":151,"lon":150},[154],{"name":155,"role":23,"phone":156,"phoneExt":19,"email":157},"Chanjuan Shen, Master","18973389928","Shenchanjuan@163.com",{"facility":159,"status":29,"city":160,"state":161,"zip":162,"country":33,"countryCode":34,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Shengjing Hospital of China Medical University","Shenyang","Liaoning","110004",{"type":36,"coordinates":164},[165,166],123.43278,41.79222,{"lat":166,"lon":165},[169],{"name":170,"role":23,"phone":171,"phoneExt":19,"email":172},"Wei Yang, Doctor","18940251012","yangw@sj-hospital.org",{"facility":174,"status":29,"city":175,"state":176,"zip":177,"country":33,"countryCode":34,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"The First Affiliated Hospital of Xi'an Jiao Tong University","Xi'an","Shaanxi","710000",{"type":36,"coordinates":179},[180,181],108.92861,34.25833,{"lat":181,"lon":180},[184],{"name":185,"role":23,"phone":186,"phoneExt":19,"email":187},"PengCheng He, Doctor","18991232609","hpec_gcp@163.com",{"facility":189,"status":29,"city":190,"state":191,"zip":192,"country":33,"countryCode":34,"cosmosGeoPoint":19,"geoPoint":19,"contacts":193},"Tai'an Central Hospital (Tai'an Central Hospital affiliated to Qingdao University, Mount Taishan Medical Center)","Taian","Shandong","271099",[194],{"name":195,"role":23,"phone":196,"phoneExt":19,"email":197},"Guanchen Bai, Bachelor","18653819776","bgcbgc1@163.com",{"facility":199,"status":29,"city":200,"state":191,"zip":201,"country":33,"countryCode":34,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Zibo Central Hospital","Zibo","255036",{"type":36,"coordinates":203},[204,205],118.06333,36.79056,{"lat":205,"lon":204},[208],{"name":209,"role":23,"phone":210,"phoneExt":19,"email":211},"Zhencheng Wang, Bachelor","13905332095","wangzhenchenggcp@163.com",{"facility":213,"status":214,"city":215,"state":216,"zip":217,"country":33,"countryCode":34,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"ShangHai Tongren Hospital","RECRUITING","Shanghai","Shanghai Municipality","200000",{"type":36,"coordinates":219},[220,221],121.45806,31.22222,{"lat":221,"lon":220},[224],{"name":225,"role":23,"phone":226,"phoneExt":19,"email":227},"LiGen Liu, Master","18017337037","llg3532@shtrhospital.com",{"facility":229,"status":29,"city":215,"state":216,"zip":230,"country":33,"countryCode":34,"cosmosGeoPoint":231,"geoPoint":233,"contacts":234},"Shanghai Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital","200437",{"type":36,"coordinates":232},[220,221],{"lat":221,"lon":220},[235,239],{"name":236,"role":23,"phone":237,"phoneExt":19,"email":238},"Wenwei Zhu, Doctor","18930565525","wwz3006@163.com",{"name":240,"role":23,"phone":241,"phoneExt":19,"email":242},"Lin Geng, Master","021-5538591","Drgenglin@163.com",{"facility":244,"status":29,"city":215,"state":216,"zip":245,"country":33,"countryCode":34,"cosmosGeoPoint":246,"geoPoint":248,"contacts":249},"Shanghai Pudong New Area People's Hospital","201200",{"type":36,"coordinates":247},[220,221],{"lat":221,"lon":220},[250],{"name":251,"role":23,"phone":252,"phoneExt":19,"email":253},"Guangru Xu, Master","13916950375","xuggrr@sina.com",{"facility":255,"status":29,"city":256,"state":257,"zip":258,"country":33,"countryCode":34,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"People's hospital of deyang city","Deyang","Sichuan","618099",{"type":36,"coordinates":260},[261,262],104.38198,31.13019,{"lat":262,"lon":261},[265],{"name":266,"role":23,"phone":267,"phoneExt":19,"email":268},"Jie Zhou, Master","13881055441","zhoujie_gcp@163.com",{"facility":270,"status":29,"city":271,"state":272,"zip":273,"country":33,"countryCode":34,"cosmosGeoPoint":274,"geoPoint":278,"contacts":279},"Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","Tianjin","Tianjin Municipality","300020",{"type":36,"coordinates":275},[276,277],117.17667,39.14222,{"lat":277,"lon":276},[280],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},{"facility":282,"status":29,"city":271,"state":272,"zip":283,"country":33,"countryCode":34,"cosmosGeoPoint":284,"geoPoint":286,"contacts":287},"People's Hospital of Tianjin (City)","300122",{"type":36,"coordinates":285},[276,277],{"lat":277,"lon":276},[288],{"name":289,"role":23,"phone":290,"phoneExt":19,"email":291},"Xingli Zhao, Postdoctoral","13752255454","tjsrmyyxyk@163.com",{"facility":293,"status":29,"city":294,"state":295,"zip":296,"country":33,"countryCode":34,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"The First Affiliated Hospital of Xinjiang Medical University","Ürümqi","Xinjiang","830000",{"type":36,"coordinates":298},[299,300],87.60046,43.80096,{"lat":300,"lon":299},[303],{"name":304,"role":23,"phone":305,"phoneExt":19,"email":306},"Jianhua Qu, Master","13199855506","jhuaqu@163.com",{"facility":308,"status":29,"city":309,"state":310,"zip":311,"country":33,"countryCode":34,"cosmosGeoPoint":312,"geoPoint":316,"contacts":317},"The First Affiliated Hospital of Ningbo University","Ningbo","Zhejiang","315010",{"type":36,"coordinates":313},[314,315],121.54945,29.87819,{"lat":315,"lon":314},[318],{"name":319,"role":23,"phone":320,"phoneExt":19,"email":321},"ShanHao Tang, Doctor","13777113112","txtx1978@163.com",{"type":323,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100593803","phase-1-a-clinical-trial-of-tqb3909-tablets-in-combination-with-azacitidine-for-the-treatment-of-myeloid-malignancies-100593803",false,"NCT07011186","A Clinical Trial of TQB3909 Tablets in Combination With Azacitidine for the Treatment of Myeloid Malignancies","A Phase Ib\u002FII Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of TQB3909 Tablets in Combination With Azacitidine in Subjects With Myeloid Malignancies","Inclusion Criteria:\n\n* Voluntary and signed informed consent, good compliance\n* Age: ≥18 years old (at the time of signing the informed consent); expected survival time greater than 3 months.\n* Diagnosis of one of the following diseases:\n\n  1. Acute Myeloid Leukemia (AML):\n  2. Myelodysplastic Syndromes (MDS)\n  3. Major organ functions are normal.\n  4. Fertile male and female subjects agree to use contraception during the study and for 6 months after the study ends.\n\nExclusion Criteria:\n\n* Comorbidities and Medical History:\n\n  1. Diagnosis of or current concomitant malignancy within 3 years prior to the first dose;\n  2. Presence of multiple factors affecting oral drug intake and\u002For absorption;\n  3. Major surgical procedures or significant traumatic injuries within 28 days prior to the first dose;\n  4. History of arterial\u002Fvenous thrombotic events within 6 months prior to the first dose;\n  5. History of psychiatric drug abuse that cannot be discontinued, or psychiatric disorders;\n  6. Presence of any severe and\u002For uncontrolled disease in the subject.\n* Tumor-related Symptoms and Treatment:\n\n  1. Diagnosis of Acute Promyelocytic Leukemia (APL), Myelodysplastic Syndromes\u002FMyeloproliferative Neoplasms (MDS\u002FMPN);\n  2. Presence of leukemia central nervous system (CNS) involvement or high suspicion of CNS involvement but unable to confirm;\n  3. Subjects with extramedullary disease only in AML;\n  4. Presence of life-threatening severe leukemia-related complications;\n* Study Treatment-related:\n\n  1. Received live vaccines within 4 weeks prior to the first dose, or planned to receive live vaccines during the study period;\n  2. Participated in other clinical trials involving anti-tumor drugs within 4 weeks prior to the first dose.","ALL","18 Years",{"count":334,"type":335},138,"ESTIMATED","INTERVENTIONAL",[338,339],"PHASE1","PHASE2","This is an open, multi-center clinical study designed to evaluate the safety, tolerability and efficacy of TQB3909 tablets in combination with azacitidine in subjects with myeloid malignancies.",[342],"Myeloid Malignancy","2025-05-30",{"date":345,"type":346},"2025-06-08","ACTUAL",{"date":348,"type":346},"2024-04-17",{"date":350,"type":335},"2026-10",{"name":5,"class":6},21]