[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600736":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":42,"centralContacts":43,"locations":49,"responsibleParty":61,"collaborators":42,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":42,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":42,"studyType":76,"phases":77,"briefSummary":80,"conditions":81,"keywords":42,"overallStatus":85,"whyStopped":42,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Control group receiving 10 ml of normal saline after induction of anesthesia then followed by infusion of normal saline till extubation in ICU",[13],"Drug: Normal saline",{"label":15,"type":10,"description":16,"interventionNames":17},"Dexmedetomidine","Starting with precedex loading dose after anesthesia induction then infusion till extubation in ICU",[18],"Drug: Dexmedetomidine",{"label":20,"type":10,"description":21,"interventionNames":22},"Methylprednisolone","To be diluted in 10 ml normal saline then given after induction of anesthesia then followed by normal saline infusion till extubation in ICU",[23],"Drug: Methylprednisolone",[25,32,37],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Normal saline","After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU",[9],[31],"Control group (placebo)",{"type":26,"name":15,"description":33,"armGroupLabels":34,"otherNames":35},"After induction of anesthesia give loading dose of precedex 1 mcg\u002Fkg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg\u002Fkg\u002Fhr till extubation in ICU",[15],[36],"Precedex (active comparator)",{"type":26,"name":20,"description":38,"armGroupLabels":39,"otherNames":40},"After induction of anesthesia give solumedrol of a dose 10mg\u002Fkg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU",[20],[41],"Solumedrol (active comparator)",null,[44],{"name":45,"role":46,"phone":47,"phoneExt":42,"email":48},"Assem Abourawash, Masters","CONTACT","00201064013278","assemahmed999@gmail.com",[50],{"facility":5,"status":42,"city":51,"state":52,"zip":42,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":42},"Cairo","Cairo Governorate","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.24967,30.06263,{"lat":59,"lon":58},{"type":62,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100600736","phase-1-a-comparative-study-between-dexmedetomidine-versus-methylprednisolone-on-induced-inflammatory-response-in-patients-undergoing-on-pump-cabg-100600736",false,"NCT07101367","A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG","Inclusion Criteria:\n\n1. Age 21-60 years.\n2. Sex: Both sexes.\n3. American Society of Anaesthesiologists (ASA) Physical Status Class II, and III.\n4. Scheduled for CABG on cardio-pulmonary bypass.\n\nExclusion Criteria:\n\n1. Declining to give a written informed consent.\n2. History of allergy to the medications used in the study.\n3. Psychiatric disorders.\n4. Significant cognitive dysfunction.\n5. American Society of Anesthesiologists (ASA) Physical Status Class IV.\n6. Chronic liver or kidney disease.\n7. Poor systolic function ( Ejection fraction \\\u003C 40% ).\n8. Pregnancy.\n9. Redo CABG.\n\n9.Infection during the week preceding surgery white blood cell count over 11,000 mm3 10.Pre-operative use of antibiotics or corticosteroids.",true,"ALL","21 Years","60 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78,79],"PHASE1","PHASE2","A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive and cardiac status post extubation",[82,83,84],"Coronary Artery Disease","Systemic Inflammatory Response Syndrome","Postoperative Complications","NOT_YET_RECRUITING","2025-08-01",{"date":88,"type":89},"2025-08-06","ACTUAL",{"date":91,"type":75},"2025-09-01",{"date":93,"type":75},"2026-08-31",{"name":5,"class":6},1]