[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642954":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":19,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":19,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":19,"enrollmentInfo":56,"targetDuration":19,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Shanghai EpimAb Biotherapeutics Co., Ltd.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"EMB-15","EXPERIMENTAL","This is an open-label, non-randomized dose-escalation study comprising a dose-escalation phase and a dose-expansion phase. It's planned to recruit approximately 50 patients (the final number will be determined depending on the number of dose levels) with locally advanced or metastatic solid tumors. The trial consists of a screening period (Day -28 to Day -1), a step-up dose period (applicable only to doses with higher CRS risk, lasting 7 days or longer), a treatment period (28 days per cycle, up to 2 years), and a safety follow-up period (30 days after the last dose).",[13],"Biological: EMB-15",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"BIOLOGICAL","EMB-15 is a recombinant humanized bi-specific antibody against ALPP\u002FALPG and CD3",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Xi Yang","CONTACT","86-21-61951000","xyang@epimab.com",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Sixth Affiliated Hospital of Sun Yat-sen University","RECRUITING","Guangzhou","Guangdong","510655","China","CN",{"type":36,"coordinates":37},"Point",[38,39],113.25,23.11667,{"lat":39,"lon":38},[42],{"name":43,"role":23,"phone":24,"phoneExt":19,"email":44},"Mingfei Zhang","mfzhang@epimab.com",{"type":46,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100642954","phase-1-a-first-in-human-phase-i-study-to-evaluate-emb-15-in-patients-with-locally-advanced-or-metastatic-solid-tumors-100642954",false,"NCT07607054","A First-in-human Phase I Study to Evaluate EMB-15 in Patients With Locally Advanced or Metastatic Solid Tumors.","A First-in-Human, Phase I, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Antitumor Activity of EMB-15 in Patients With Locally Advanced or Metastatic Solid Tumors","Inclusion Criteria:\n\n\\- 1) Able to understand and willing to sign an ICF 2) Males or females with the age ≥ 18 years 3) Life expectancy \\> 3 months. 4) ECOG performance status 0 or 1 5) Patients must have histologically or cytologically confirmed locally advanced or metastatic solid tumors, without standard therapy.\n\n6\\) Patients must provide archived tumor samples collected within 1 year. 7) Adequate hematological and organ function.\n\nExclusion Criteria:\n\n* Patients meeting any of the following criteria will not be enrolled:\n\n  1. Any prior ALPP\u002FALPG targeting therapy\n  2. Has received anticancer therapy, radiotherapy, or investigational drug within \\\u003C 5 half-lives or 4 weeks (whichever is shorter) prior to study treatment;\n  3. Active autoimmune disease or history of autoimmune disease\n  4. Concurrent malignancy \\\u003C 5 years prior to study entry\n  5. active infection\n  6. Severe or uncontrolled cardiovascular disease requiring treatment\n  7. Other severe medical conditions","ALL","18 Years",{"count":57,"type":58},50,"ESTIMATED","INTERVENTIONAL",[61],"PHASE1","The primary purpose of this study is to evaluate safety and tolerability profile of EMB-15, identify the recommended Phase 2 dose(s) (RP2Ds) for EMB-15. Pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and the anti-tumor activity of EMB-15 will also be assessed.",[64],"Locally Advanced or Metastatic Solid Tumors",[66,9],"Phase 1","2026-06-11",{"date":69,"type":70},"2026-06-15","ACTUAL",{"date":72,"type":58},"2026-05-26",{"date":74,"type":58},"2029-10-30",{"name":5,"class":6},1]