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Then several dose levels will be selected as the recommended dose for expansion (RDE).",[13],"Drug: YL217",{"label":15,"type":10,"description":16,"interventionNames":17},"Part 1: Dose-Escalation Part","Participants will receive escalating doses of YL217 until doses for optimization are determined",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Part 3: Dose-Expansion Part","Upon completion of Part 1 and Part 2 with determination of MTD\u002FRDE(s), the dose-expansion part will be conducted to further support the RP2D selection.",[13],[23,29,31],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","YL217","Patients will be treated with YL217 intravenous(IV)infusion.",[15],null,{"type":24,"name":25,"description":26,"armGroupLabels":30,"otherNames":28},[19],{"type":24,"name":25,"description":26,"armGroupLabels":32,"otherNames":28},[9],[34],{"name":35,"role":36,"phone":37,"phoneExt":28,"email":38},"Angie Cao, MD","CONTACT","+86 0512-62858368","clinicaltrials@medilinkthera.com",[40,57,69,79,91,104,116,127,139,151,162,174,185,197,211,223,235,247,259],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Mayo Clinic Arizona","RECRUITING","Phoenix","Arizona","85054","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-112.07404,33.44838,{"lat":52,"lon":51},[55],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},"Study Coordinator",{"facility":58,"status":42,"city":59,"state":60,"zip":61,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"UCLA Hematology\u002FOncology - Santa Monica","Santa 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Center","Cincinnati","Ohio","45219",{"type":49,"coordinates":145},[146,147],-84.51439,39.12711,{"lat":147,"lon":146},[150],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":152,"status":42,"city":153,"state":142,"zip":154,"country":46,"countryCode":47,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Cleveland Clinic Taussig Cancer Institute","Cleveland","44195",{"type":49,"coordinates":156},[157,158],-81.69541,41.4995,{"lat":158,"lon":157},[161],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":163,"status":42,"city":164,"state":165,"zip":166,"country":46,"countryCode":47,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"The University of Texas MD Anderson Cancer Center","Houston","Texas","77030",{"type":49,"coordinates":168},[169,170],-95.36327,29.76328,{"lat":170,"lon":169},[173],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":175,"status":42,"city":176,"state":165,"zip":177,"country":46,"countryCode":47,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"UT Health San Antonio - Mays Cancer Center","San Antonio","78229",{"type":49,"coordinates":179},[180,181],-98.49363,29.42412,{"lat":181,"lon":180},[184],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":186,"status":93,"city":187,"state":188,"zip":189,"country":46,"countryCode":47,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"University of Wisconsin Health - UW Carbone Cancer Center","Madison","Wisconsin","53792",{"type":49,"coordinates":191},[192,193],-89.40123,43.07305,{"lat":193,"lon":192},[196],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":198,"status":42,"city":199,"state":200,"zip":201,"country":202,"countryCode":203,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"Peking Union Medical College Hospital","Beijing","Bejing","100730","China","CN",{"type":49,"coordinates":205},[206,207],116.39723,39.9075,{"lat":207,"lon":206},[210],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":212,"status":93,"city":213,"state":214,"zip":215,"country":202,"countryCode":203,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"Harbin Medical University Cancer 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Municipality","200025",{"type":49,"coordinates":241},[242,243],121.45806,31.22222,{"lat":243,"lon":242},[246],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":248,"status":42,"city":249,"state":250,"zip":251,"country":202,"countryCode":203,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"Tianjin Medical University Cancer Institute & Hospital","Tianjin","Tianjin Municipality","300060",{"type":49,"coordinates":253},[254,255],117.17667,39.14222,{"lat":255,"lon":254},[258],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"facility":260,"status":93,"city":261,"state":262,"zip":263,"country":202,"countryCode":203,"cosmosGeoPoint":264,"geoPoint":268,"contacts":269},"Zhejiang Cancer Hospital","Hangzhou","Zhejiang","310022",{"type":49,"coordinates":265},[266,267],120.16142,30.29365,{"lat":267,"lon":266},[270],{"name":56,"role":36,"phone":28,"phoneExt":28,"email":28},{"type":272,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100582165","phase-1-a-first-in-human-study-of-yl217-in-patients-with-advanced-solid-tumors-100582165",false,"NCT06859762","A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors","A Phase 1, Multicenter, Open-Label, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of YL217 in Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n* Informed of the study before the start of the study and voluntarily sign their name and date in the ICF\n* Able and willing to comply with protocol visits and procedures\n* Age≥ 18 years\n* ECOG PS of 0 or 1\n* Tumor types as below:\n\nFor Part 1 and Part 2: Pathologically confirmed diagnosis of an advanced solid tumor.\n\nFor Part 3 (Histologically or cytologically confirmed diagnosis+ locally advanced unresectable or metastatic disease)\n\n* Adequate organ and bone marrow function.\n* Have at least 1 extracranial measurable tumor lesion.\n* Adequate archival formalin-fixed paraffin embedded （FFPE） tissue from prior biopsy.\n\nExclusion Criteria:\n\n* Prior treatment with an agent targeting CDH17\n* Prior discontinuation of a topoisomerase I inhibitor due to treatment-related toxicities.\n* Have received an ADC consisting of a topoisomerase I inhibitor.\n* Concurrent enrollment in another clinical study, unless it is an observational clinical study.\n* Inadequate washout period for prior anticancer treatment before the first dose of study drug\n* Undergone major surgery within 4 weeks before the first dose of study drug or expect major surgery during the study.\n* Received long term systemic steroids or other immunosuppressive therapy within 2 weeks before the first dose of study drug.\n* Received any live vaccine within 4 weeks before the first dose of study drug or intend to receive a live vaccine during the study.\n* Diagnosis or evidence of spinal cord compression or leptomeningeal carcinomatosis.\n* Uncontrolled or clinically significant cardiovascular and cerebrovascular diseases.\n* A history of non-infectious interstitial lung disease (ILD)\u002Fpneumonitis that requires steroids, current active ILD\u002Fpneumonitis.\n* Have clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses.\n* Uncontrolled third-space fluid that requires repeated drainage.\n* Digestive system disease that may cause bleeding, perforation, jaundice, gastrointestinal obstruction.\n* An active tuberculosis based on medical history.\n* Known human immunodeficiency virus (HIV) infection.\n* Active hepatitis C infection.","ALL","18 Years",{"count":283,"type":284},220,"ESTIMATED","INTERVENTIONAL",[287],"PHASE1","A Phase 1 First-in-Human study of YL217 in Patients with Advanced Solid Tumors",[290],"Advanced Solid Tumor","2026-01-12",{"date":293,"type":294},"2026-01-14","ACTUAL",{"date":296,"type":294},"2025-07-02",{"date":298,"type":284},"2027-07",{"name":5,"class":6},19]