[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592715":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":46,"centralContacts":49,"locations":57,"responsibleParty":334,"collaborators":11,"id":336,"slug":337,"hasResults":338,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":11,"eligibilityCriteria":342,"healthyVolunteers":338,"sex":343,"minAge":344,"maxAge":11,"enrollmentInfo":345,"targetDuration":11,"studyType":348,"phases":349,"briefSummary":351,"conditions":352,"keywords":356,"overallStatus":60,"whyStopped":11,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":369},{"fullName":5,"class":6},"Bristol-Myers Squibb","INDUSTRY",[8,14,19,22,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1A Monotherapy Dose Escalation","EXPERIMENTAL",null,[13],"Drug: BMS-986500",{"label":15,"type":10,"description":11,"interventionNames":16},"Part 1B Combination Dose Escalation",[13,17,18],"Drug: Palbociclib","Drug: Fulvestrant",{"label":20,"type":10,"description":11,"interventionNames":21},"Part 1C Monotherapy Pharmacodynamic (PD) Sub-study",[13],{"label":23,"type":10,"description":11,"interventionNames":24},"Part 2A Monotherapy Dose Expansion",[13],{"label":26,"type":10,"description":11,"interventionNames":27},"Part 2B Combination Dose Expansion",[13,17,18],[29,34,41],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"DRUG","BMS-986500","Specified dose of specified days",[9,15,20,23,26],{"type":30,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Palbociclib","Specified dose on specified days",[15,26],[39,40],"IBRANCE®","PD 0332991",{"type":30,"name":42,"description":36,"armGroupLabels":43,"otherNames":44},"Fulvestrant",[15,26],[45],"FASLODEX®",[47],{"name":5,"affiliation":5,"role":48},"STUDY_DIRECTOR",[50,55],{"name":51,"role":52,"phone":53,"phoneExt":11,"email":54},"BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, www.BMSStudyConnect.com","CONTACT","855-907-3286","Clinical.Trials@bms.com",{"name":56,"role":52,"phone":11,"phoneExt":11,"email":11},"First line of the email MUST contain NCT # and Site #.",[58,76,90,103,116,129,143,157,170,184,198,210,221,231,245,258,274,287,303,317,326],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"University of Alabama at Birmingham","RECRUITING","Birmingham","Alabama","35294-3300","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-86.80249,33.52066,{"lat":70,"lon":69},[73],{"name":74,"role":52,"phone":75,"phoneExt":11,"email":11},"Mehmet Akce, Site 0001","205-975-0832",{"facility":77,"status":60,"city":78,"state":79,"zip":80,"country":64,"countryCode":65,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Providence St. Jude Medical Center","Fullerton","California","92835",{"type":67,"coordinates":82},[83,84],-117.92534,33.87029,{"lat":84,"lon":83},[87],{"name":88,"role":52,"phone":89,"phoneExt":11,"email":11},"Yung Lyou, Site 0003","714-446-5900",{"facility":91,"status":60,"city":92,"state":79,"zip":93,"country":64,"countryCode":65,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Marin Cancer Care","Greenbrae","94904",{"type":67,"coordinates":95},[96,97],-122.5247,37.94854,{"lat":97,"lon":96},[100],{"name":101,"role":52,"phone":102,"phoneExt":11,"email":11},"Cyrus Mazidi, Site 0013","415-925-5000",{"facility":104,"status":60,"city":105,"state":79,"zip":106,"country":64,"countryCode":65,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Moores Cancer Center","La Jolla","92093",{"type":67,"coordinates":108},[109,110],-117.2742,32.84727,{"lat":110,"lon":109},[113],{"name":114,"role":52,"phone":115,"phoneExt":11,"email":11},"Peter Vu, Site 0009","858-822-2463",{"facility":117,"status":60,"city":118,"state":79,"zip":119,"country":64,"countryCode":65,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Hoag Memorial Hospital Presbyterian","Newport Beach","92663",{"type":67,"coordinates":121},[122,123],-117.92895,33.61891,{"lat":123,"lon":122},[126],{"name":127,"role":52,"phone":128,"phoneExt":11,"email":11},"Monica Mita, Site 0010","949-764-4060",{"facility":130,"status":131,"city":132,"state":133,"zip":134,"country":64,"countryCode":65,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Local Institution - 0008","NOT_YET_RECRUITING","Aurora","Colorado","80045",{"type":67,"coordinates":136},[137,138],-104.83192,39.72943,{"lat":138,"lon":137},[141],{"name":142,"role":52,"phone":11,"phoneExt":11,"email":11},"Site 0008",{"facility":144,"status":60,"city":145,"state":146,"zip":147,"country":64,"countryCode":65,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Dana-Farber Cancer Institute","Boston","Massachusetts","02215",{"type":67,"coordinates":149},[150,151],-71.05977,42.35843,{"lat":151,"lon":150},[154],{"name":155,"role":52,"phone":156,"phoneExt":11,"email":11},"Joyce Liu, Site 0006","617-632-5269",{"facility":158,"status":60,"city":159,"state":160,"zip":161,"country":64,"countryCode":65,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Washington University School of Medicine","St Louis","Missouri","63110",{"type":67,"coordinates":163},[164,165],-90.19789,38.62727,{"lat":165,"lon":164},[168],{"name":169,"role":52,"phone":11,"phoneExt":11,"email":11},"Faisal Fa'ak, Site 0004",{"facility":171,"status":60,"city":172,"state":173,"zip":174,"country":64,"countryCode":65,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"Dartmouth-Hitchcock Medical Center","Lebanon","New Hampshire","03756",{"type":67,"coordinates":176},[177,178],-72.25176,43.64229,{"lat":178,"lon":177},[181],{"name":182,"role":52,"phone":183,"phoneExt":11,"email":11},"Lionel Lewis, Site 0002","603-381-1953",{"facility":185,"status":60,"city":186,"state":187,"zip":188,"country":64,"countryCode":65,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"Roswell Park Cancer Institute","Buffalo","New York","14263",{"type":67,"coordinates":190},[191,192],-78.87837,42.88645,{"lat":192,"lon":191},[195],{"name":196,"role":52,"phone":197,"phoneExt":11,"email":11},"Christos Fountzilas, Site 0014","716-574-7043",{"facility":199,"status":60,"city":200,"state":187,"zip":201,"country":64,"countryCode":65,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Northwell Health-Cancer Institute","New Hyde Park","11042",{"type":67,"coordinates":203},[204,205],-73.68791,40.7351,{"lat":205,"lon":204},[208],{"name":209,"role":52,"phone":11,"phoneExt":11,"email":11},"Geraldine O'Sullivan Coyne, Site 0016",{"facility":211,"status":131,"city":187,"state":187,"zip":212,"country":64,"countryCode":65,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Local Institution - 0011","10016",{"type":67,"coordinates":214},[215,216],-74.00597,40.71427,{"lat":216,"lon":215},[219],{"name":220,"role":52,"phone":11,"phoneExt":11,"email":11},"Site 0011",{"facility":222,"status":60,"city":187,"state":187,"zip":223,"country":64,"countryCode":65,"cosmosGeoPoint":224,"geoPoint":226,"contacts":227},"Memorial Sloan Kettering Cancer Center","10065",{"type":67,"coordinates":225},[215,216],{"lat":216,"lon":215},[228],{"name":229,"role":52,"phone":230,"phoneExt":11,"email":11},"Ezra Rosen, Site 0012","000-000-0000",{"facility":232,"status":60,"city":233,"state":234,"zip":235,"country":64,"countryCode":65,"cosmosGeoPoint":236,"geoPoint":240,"contacts":241},"START Dallas Fort Worth","Fort Worth","Texas","76104",{"type":67,"coordinates":237},[238,239],-97.32085,32.72541,{"lat":239,"lon":238},[242],{"name":243,"role":52,"phone":244,"phoneExt":11,"email":11},"Henry Xiong, Site 0018","682-350-3010",{"facility":246,"status":60,"city":247,"state":234,"zip":248,"country":64,"countryCode":65,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"NEXT Oncology","San Antonio","78229",{"type":67,"coordinates":250},[251,252],-98.49363,29.42412,{"lat":252,"lon":251},[255],{"name":256,"role":52,"phone":257,"phoneExt":11,"email":11},"David Sommerhalder, Site 0007","210-580-9500",{"facility":259,"status":60,"city":260,"state":261,"zip":262,"country":263,"countryCode":264,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"Odense Universitetshospital","Odense","Region Syddanmark","5000","Denmark","DK",{"type":67,"coordinates":266},[267,268],10.38831,55.39594,{"lat":268,"lon":267},[271],{"name":272,"role":52,"phone":273,"phoneExt":11,"email":11},"Annette Kodahl, Site 0024","004566113333",{"facility":275,"status":60,"city":276,"state":11,"zip":277,"country":263,"countryCode":264,"cosmosGeoPoint":278,"geoPoint":282,"contacts":283},"Copenhagen University Hospital","Copenhagen","2100",{"type":67,"coordinates":279},[280,281],12.56553,55.67594,{"lat":281,"lon":280},[284],{"name":285,"role":52,"phone":286,"phoneExt":11,"email":11},"Martin Højgaard, Site 0025","4535456861",{"facility":288,"status":60,"city":289,"state":290,"zip":291,"country":292,"countryCode":293,"cosmosGeoPoint":294,"geoPoint":298,"contacts":299},"National Cancer Center Hospital East","Kashiwa","Chiba","277-8577","Japan","JP",{"type":67,"coordinates":295},[296,297],139.97732,35.86224,{"lat":297,"lon":296},[300],{"name":301,"role":52,"phone":302,"phoneExt":11,"email":11},"Chikako Funasaka, Site 0021","81471331111",{"facility":304,"status":60,"city":305,"state":306,"zip":307,"country":292,"countryCode":293,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Kansai Medical University Hospital","Hirakata","Osaka","573-1191",{"type":67,"coordinates":309},[310,311],135.64914,34.81352,{"lat":311,"lon":310},[314],{"name":315,"role":52,"phone":316,"phoneExt":11,"email":11},"Toshio Shimizu, Site 0020","+81728040101",{"facility":318,"status":60,"city":319,"state":320,"zip":321,"country":292,"countryCode":293,"cosmosGeoPoint":11,"geoPoint":11,"contacts":322},"National Cancer Center Hospital","Chuo-ku","Tokyo","104-0045",[323],{"name":324,"role":52,"phone":325,"phoneExt":11,"email":11},"Takafumi Koyama, Site 0022","81335422511",{"facility":327,"status":60,"city":328,"state":320,"zip":329,"country":292,"countryCode":293,"cosmosGeoPoint":11,"geoPoint":11,"contacts":330},"The Cancer Institute Hospital of JFCR","Koto-ku","135-8550",[331],{"name":332,"role":52,"phone":333,"phoneExt":11,"email":11},"Shigehisa Kitano, Site 0023","0335200111",{"type":335,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100592715","phase-1-a-phase-1-study-of-bms-986500-as-monotherapy-or-combination-therapy-in-advanced-solid-tumors-100592715",false,"NCT06997029","A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors","A Phase 1 First-in-human Study of BMS-986500 as Monotherapy in Advanced Solid Tumors and as Combination Therapy in CDK4\u002F6 Inhibitor Pre-treated Advanced Breast Cancer","Inclusion Criteria:\n\n* Participants must be ≥ 18 years of age.\n* Participants must have histologically confirmed diagnosis of a locally advanced, unresectable, or metastatic solid tumor malignancy.\n* Participants must have a measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1\n* Participants must have a stable Eastern Cooperative Oncology Group Performance Status of 0 or 1.\n* For Part 2A only, participants must have CCNE1-amplified ovarian cancer\n\nExclusion Criteria:\n\n* Participants must not have an active brain metastasis.\n* Participants must not have impaired cardiac function or clinically significant cardiac disease.\n* Participants must not have bleeding disorder or any history of clinically significant bleeding within the prior 3 months.\n* Participants must not have Grade ≥ 2 peripheral neuropathy.\n* Other protocol-defined Inclusion\u002FExclusion criteria apply.","ALL","18 Years",{"count":346,"type":347},234,"ESTIMATED","INTERVENTIONAL",[350],"PHASE1","The purpose of this study is to assess BMS-986500 as monotherapy in advanced solid tumors and as combination therapy in CDK4\u002F6 inhibitor pre-treated advanced breast cancer.",[353,354,355],"Advanced Solid Tumor","Advanced Breast Cancer","Advanced Ovarian Cancer",[357,358,359],"cancer","oncology","solid tumor","2026-07-01",{"date":362,"type":363},"2026-07-02","ACTUAL",{"date":365,"type":363},"2025-08-01",{"date":367,"type":347},"2028-12-14",{"name":5,"class":6},21]