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Has histologically or cytologically confirmed advanced or metastatic solid tumor\n2. Have received ≥12 weeks of continuous anti-PD-1 or anti-PD-L1 treatment administered as monotherapy or in combination with other anticancer therapies\n3. Have demonstrated documented prior clinical benefit, defined as CR or PR at any time during treatment, or SD lasting ≥6 months (Part 2 only)\n4. Must have subsequently developed radiographic disease progression while receiving anti-PD-1 or anti-PD-L1 treatment or within ≤12 weeks after the last dose of such treatment\n5. At least 1 measurable lesion, as defined by RECIST v1.1\n6. Estimated survival of ≥3 months\n7. Have adequate bone marrow and organ function.\n8. A female participant is eligible to participate if she is not pregnant, not breastfeeding\n\nExclusion Criteria:\n\n1. Any immune-related medical conditions that would put participants at greater risk when receiving pembrolizumab\n2. Has a known additional malignancy that is progressing or has required active treatment within the past 2 years\n3. Has received prior radiotherapy within 2 weeks for palliative bone-directed therapy and 4 weeks for all other radiotherapy\n4. Has undergone major surgery within 4 weeks prior to the first dose of study treatment or has not adequately recovered from surgery or related complications\n5. Has a diagnosis of immunodeficiency or use of systemic steroids \\>10 mg\u002Fday\n6. Has an active autoimmune disease that has required systemic treatment in the past 2 years\n7. Has known active CNS metastases (brain and\u002For leptomeningeal metastases)\n8. Has significant cardiac disease\n9. Has an active infection requiring systemic therapy (including uncontrolled HIV, Hepatitis B and C)\n10. 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