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For pediatric participants an estimated or measured glomerular filtration rate \\>=40 mL\u002Fmin per the CKiD (Chronic Kidney Disease in Children) Schwartz formula\n* Eastern Cooperative Oncology Group (ECOG) performance status grade of 0, 1 or 2. Pediatric participants only: Performance status \\>=70 by Lansky scale (for participants \\\u003C 16 years of age) or \\>=70 Karnofsky scale (for participants \\>=16 years of age)\n* A female of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin at screening and within 48 hours prior to the first dose of study treatment\n* Participant must agree to all protocol required contraception requirements and avoid sperm or egg donations or freezing for future reproductive use while on study and for 90 days (males) or 6 months (females) after the last dose of study treatment\n\nExclusion Criteria:\n\n* Acute promyelocytic leukemia, diagnosis of Down syndrome associated leukemia or juvenile myelomonocytic leukemia according to World Health Organization (WHO) 2016 criteria\n* Active central nervous system (CNS) disease\n* Prior solid organ transplantation\n* QTc according to Fridericia's formula (QTcF) for males \\>= 450 millisecond (msec) or for females \\>= 470 msec. Participants with a family history of Long QT syndrome are excluded\n* Exclusion criteria related to stem cell transplant: a. Received prior treatment with allogenic bone marrow or stem cell transplant \\\u003C=3 months before the first dose of study treatment ; b. Has evidence of graft versus host disease; c. Received donor lymphocyte infusion \\\u003C=1 month before the first dose of study treatment; d. Requires immunosuppressant therapy (exception: daily doses \\\u003C=10 milligrams (mg) prednisone or equivalent are allowed for adrenal replacement)\n* Prior cancer immunotherapy within 4 weeks prior to enrollment or blinatumomab within 2 weeks prior to enrollment. Additional prior cancer therapies must not be given within 4 weeks prior to enrollment or 5 half-lives of the agent (whichever is shorter)","ALL","2 Years",{"count":967,"type":968},420,"ESTIMATED","INTERVENTIONAL",[971,972],"PHASE1","PHASE2","The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D\\[s\\]) of bleximenib in phase 1 Part 1 (Dose Escalation) and to determine the safety and tolerability at RP2D in Phase 1 Part 2 (Dose expansion). The purpose of the Phase 2 part of the study is to evaluate the efficacy of bleximenib at the RP2D.",[975],"Acute Leukemia","2026-06-04",{"date":978,"type":979},"2026-06-08","ACTUAL",{"date":981,"type":979},"2021-05-19",{"date":983,"type":968},"2030-09-22",{"name":5,"class":6},102]