[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462646":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":29,"locations":35,"responsibleParty":629,"collaborators":28,"id":631,"slug":632,"hasResults":633,"nctId":634,"briefTitle":635,"officialTitle":636,"acronym":637,"eligibilityCriteria":638,"healthyVolunteers":633,"sex":639,"minAge":640,"maxAge":28,"enrollmentInfo":641,"targetDuration":28,"studyType":644,"phases":645,"briefSummary":647,"conditions":648,"keywords":652,"overallStatus":38,"whyStopped":28,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":663,"completionDateStruct":665,"leadSponsor":667,"locationsCount":668},{"fullName":5,"class":6},"Enliven Therapeutics","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1a Dose Escalation","EXPERIMENTAL","ELVN-001 administered in 3+3 dose escalation",[13],"Drug: ELVN-001",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1b Dose Expansion (non-T315I)","ELVN-001 administered at one or more recommended dose(s) for expansion in CML without T315I mutations",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Phase 1b expansion (T315I)","ELVN-001 administered at the recommended dose for expansion for CML with T315I mutation",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","ELVN-001","orally once or twice daily",[9,15,19],null,[30],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},"Study Contact","CONTACT","707-799-3272","ELVN-001-101@enliventherapeutics.com",[36,53,66,80,94,109,124,137,150,167,182,195,208,221,234,244,259,272,285,298,311,324,337,352,365,380,393,406,421,436,451,464,477,488,497,510,519,528,543,552,565,575,588,603,616],{"facility":37,"status":38,"city":39,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Memorial Sloan Kettering Cancer Center","RECRUITING","New York","10065","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-74.00597,40.71427,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":52,"phoneExt":28,"email":28},"Michael Mauro, MD","+1 347 798 9213",{"facility":54,"status":38,"city":55,"state":39,"zip":56,"country":41,"countryCode":42,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Montefiore Medical Center","The Bronx","10461",{"type":44,"coordinates":58},[59,60],-73.86641,40.84985,{"lat":60,"lon":59},[63],{"name":64,"role":32,"phone":65,"phoneExt":28,"email":28},"David Levitz MD","718-920-4321",{"facility":67,"status":38,"city":68,"state":69,"zip":70,"country":41,"countryCode":42,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Oregon Health & Science University-Knight Cardiovascular Institute","Portland","Oregon","97239",{"type":44,"coordinates":72},[73,74],-122.67621,45.52345,{"lat":74,"lon":73},[77],{"name":78,"role":32,"phone":79,"phoneExt":28,"email":28},"Michael Heinrich, MD","(503) 418-1964",{"facility":81,"status":38,"city":82,"state":83,"zip":84,"country":41,"countryCode":42,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"The University of Texas MD Anderson Cancer Center","Houston","Texas","77030",{"type":44,"coordinates":86},[87,88],-95.36327,29.76328,{"lat":88,"lon":87},[91],{"name":92,"role":32,"phone":93,"phoneExt":28,"email":28},"Fadi Haddad, MD","877-632-6789",{"facility":95,"status":38,"city":96,"state":28,"zip":97,"country":98,"countryCode":99,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Royal Adelaide Hospital","Adelaide","SA 5000","Australia","AU",{"type":44,"coordinates":101},[102,103],138.59863,-34.92866,{"lat":103,"lon":102},[106],{"name":107,"role":32,"phone":108,"phoneExt":28,"email":28},"Naranie Shanmuganathan, Dr","+61 8 7074 0000",{"facility":110,"status":38,"city":111,"state":28,"zip":112,"country":113,"countryCode":114,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"UZ Gent","Ghent","9000","Belgium","BE",{"type":44,"coordinates":116},[117,118],3.71667,51.05,{"lat":118,"lon":117},[121],{"name":122,"role":32,"phone":123,"phoneExt":28,"email":28},"Dominiek Mazure, Dr.","+32 9 332 21 11",{"facility":125,"status":38,"city":126,"state":28,"zip":127,"country":113,"countryCode":114,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"UZ Leuven","Leuven","3000",{"type":44,"coordinates":129},[130,131],4.70093,50.87959,{"lat":131,"lon":130},[134],{"name":135,"role":32,"phone":136,"phoneExt":28,"email":28},"Peter Vandenberghe, Dr.","+32 16 33 22 11",{"facility":138,"status":38,"city":139,"state":28,"zip":140,"country":113,"countryCode":114,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"CHU Liege","Liège","4000",{"type":44,"coordinates":142},[143,144],5.56749,50.63373,{"lat":144,"lon":143},[147],{"name":148,"role":32,"phone":149,"phoneExt":28,"email":28},"Marie Lejeune, Dr.","+32 4 323 00 00",{"facility":151,"status":38,"city":152,"state":153,"zip":154,"country":155,"countryCode":156,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"University Health Network (UHN) - Princess Margaret Cancer Centre","Toronto","Ontario","M5G 2M9","Canada","CA",{"type":44,"coordinates":158},[159,160],-79.39864,43.70643,{"lat":160,"lon":159},[163],{"name":164,"role":32,"phone":165,"phoneExt":166,"email":28},"Dong Hwan Dennis Kim, Dr","+1 416 946 4501","2464",{"facility":168,"status":38,"city":169,"state":28,"zip":170,"country":171,"countryCode":172,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"CHU Amiens Picardie Site Sud","Amiens","80054","France","FR",{"type":44,"coordinates":174},[175,176],2.3,49.9,{"lat":176,"lon":175},[179],{"name":180,"role":32,"phone":181,"phoneExt":28,"email":28},"Amandine Charbonnier, Dr","+33 322455914",{"facility":183,"status":38,"city":184,"state":28,"zip":185,"country":171,"countryCode":172,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest","Bordeaux","33076",{"type":44,"coordinates":187},[188,189],-0.58046,44.84124,{"lat":189,"lon":188},[192],{"name":193,"role":32,"phone":194,"phoneExt":28,"email":28},"Gabriel Etienne, Dr","+33 5 56 33 33 33",{"facility":196,"status":38,"city":197,"state":28,"zip":198,"country":171,"countryCode":172,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"CHRU de Lille - Hopital Calmette-Boulevard du Pr Leclercq CHRU Lille","Lille","59000",{"type":44,"coordinates":200},[201,202],3.05512,50.63391,{"lat":202,"lon":201},[205],{"name":206,"role":32,"phone":207,"phoneExt":28,"email":28},"Valerie Coiteux, Dr","+33 3 20 44 59 62",{"facility":209,"status":38,"city":210,"state":28,"zip":211,"country":171,"countryCode":172,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"Centre Hospitalier Universitaire (CHU) De Limoges Hopital Dupuytren","Limoges","87000",{"type":44,"coordinates":213},[214,215],1.24759,45.83362,{"lat":215,"lon":214},[218],{"name":219,"role":32,"phone":220,"phoneExt":28,"email":28},"Pascal Turlure, Dr","+33 5 55 05 55 55",{"facility":222,"status":38,"city":223,"state":28,"zip":224,"country":171,"countryCode":172,"cosmosGeoPoint":225,"geoPoint":229,"contacts":230},"Centre Leon Berard","Lyon","69008",{"type":44,"coordinates":226},[227,228],4.84789,45.74906,{"lat":228,"lon":227},[231],{"name":232,"role":32,"phone":233,"phoneExt":28,"email":28},"Franck Nicolini, Dr","+33 478782737",{"facility":235,"status":236,"city":237,"state":28,"zip":238,"country":171,"countryCode":172,"cosmosGeoPoint":239,"geoPoint":243,"contacts":28},"Centre Hospitalier Lyon Sud","WITHDRAWN","Pierre-Bénite","69495",{"type":44,"coordinates":240},[241,242],4.82424,45.70359,{"lat":242,"lon":241},{"facility":245,"status":38,"city":246,"state":28,"zip":247,"country":248,"countryCode":249,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"Uniklinik RWTH Aachen Medizinische","Aachen","52074","Germany","DE",{"type":44,"coordinates":251},[252,253],6.08342,50.77664,{"lat":253,"lon":252},[256],{"name":257,"role":32,"phone":258,"phoneExt":28,"email":28},"Martina Crysandt, Dr","+49 241 8080862",{"facility":260,"status":38,"city":261,"state":28,"zip":262,"country":248,"countryCode":249,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"Charite Campus Virchow","Berlin","13353",{"type":44,"coordinates":264},[265,266],13.41053,52.52437,{"lat":266,"lon":265},[269],{"name":270,"role":32,"phone":271,"phoneExt":28,"email":28},"Philipp Le Coutre, Dr","+49 30 450 665 307",{"facility":273,"status":38,"city":274,"state":28,"zip":275,"country":248,"countryCode":249,"cosmosGeoPoint":276,"geoPoint":280,"contacts":281},"Klinikum der Goethe Universitat","Frankfurt","60596",{"type":44,"coordinates":277},[278,279],10.53333,49.68333,{"lat":279,"lon":278},[282],{"name":283,"role":32,"phone":284,"phoneExt":28,"email":28},"Fabian Lang, Dr","+49 821 4861274",{"facility":286,"status":38,"city":287,"state":28,"zip":288,"country":248,"countryCode":249,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes","Homburg","66421",{"type":44,"coordinates":290},[291,292],7.33867,49.32637,{"lat":292,"lon":291},[295],{"name":296,"role":32,"phone":297,"phoneExt":28,"email":28},"Sarah Altmeyer, Dr","+49 68411615001",{"facility":299,"status":38,"city":300,"state":28,"zip":301,"country":248,"countryCode":249,"cosmosGeoPoint":302,"geoPoint":306,"contacts":307},"Universitaetsklinikum Jena","Jena","07747",{"type":44,"coordinates":303},[304,305],11.5899,50.92878,{"lat":305,"lon":304},[308],{"name":309,"role":32,"phone":310,"phoneExt":28,"email":28},"Andreas Hochhaus, Prof Dr","+49 3641 934200",{"facility":312,"status":38,"city":313,"state":28,"zip":314,"country":248,"countryCode":249,"cosmosGeoPoint":315,"geoPoint":319,"contacts":320},"Medizinische Universitatsklinik Mannheim der Universitat Heidelberg","Mannheim","68167",{"type":44,"coordinates":316},[317,318],8.46694,49.4891,{"lat":318,"lon":317},[321],{"name":322,"role":32,"phone":323,"phoneExt":28,"email":28},"Susanne Saussele, Prof Dr","+49 621 383 6966",{"facility":325,"status":38,"city":326,"state":28,"zip":327,"country":248,"countryCode":249,"cosmosGeoPoint":328,"geoPoint":332,"contacts":333},"Universitaetsmedizin Rostock","Rostock","18057",{"type":44,"coordinates":329},[330,331],12.14049,54.0887,{"lat":331,"lon":330},[334],{"name":335,"role":32,"phone":336,"phoneExt":28,"email":28},"Christian Junghanss, Dr","+49 3814947421",{"facility":338,"status":38,"city":339,"state":28,"zip":340,"country":341,"countryCode":342,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"Semmelweis Egyetem, Belgyogyaszati es Onkologiai Klinika","Budapest","1083","Hungary","HU",{"type":44,"coordinates":344},[345,346],19.04045,47.49835,{"lat":346,"lon":345},[349],{"name":350,"role":32,"phone":351,"phoneExt":28,"email":28},"Istvan Tackas MD","+36 1 459 1500",{"facility":353,"status":38,"city":354,"state":28,"zip":355,"country":341,"countryCode":342,"cosmosGeoPoint":356,"geoPoint":360,"contacts":361},"Pecsi Tudomanyegyetem Klinikai Kozpont (University of Pecs, Clinical Centre)","Pécs","7624",{"type":44,"coordinates":357},[358,359],18.22814,46.07617,{"lat":359,"lon":358},[362],{"name":363,"role":32,"phone":364,"phoneExt":28,"email":28},"Hussain Alizadeh, Dr","+36 72 501 500",{"facility":366,"status":38,"city":367,"state":28,"zip":368,"country":369,"countryCode":370,"cosmosGeoPoint":371,"geoPoint":375,"contacts":376},"Hadassah Medical Center","Jerusalem","9112001","Israel","IL",{"type":44,"coordinates":372},[373,374],35.21633,31.76904,{"lat":374,"lon":373},[377],{"name":378,"role":32,"phone":379,"phoneExt":28,"email":28},"David Lavie, Dr.","+972 02-6779267",{"facility":381,"status":38,"city":382,"state":28,"zip":383,"country":369,"countryCode":370,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"The Galilee Medical Center","Nahariya","2210001",{"type":44,"coordinates":385},[386,387],35.09814,33.00892,{"lat":387,"lon":386},[390],{"name":391,"role":32,"phone":392,"phoneExt":28,"email":28},"Galia Stemer, Dr.","+972 04-9107301",{"facility":394,"status":38,"city":395,"state":28,"zip":396,"country":369,"countryCode":370,"cosmosGeoPoint":397,"geoPoint":401,"contacts":402},"Rabin Medical Center","Petah Tikva","4941492",{"type":44,"coordinates":398},[399,400],34.88747,32.08707,{"lat":400,"lon":399},[403],{"name":404,"role":32,"phone":405,"phoneExt":28,"email":28},"Adi Shacham-Abulafia, Dr.","+972 03-9377909",{"facility":407,"status":38,"city":408,"state":28,"zip":409,"country":410,"countryCode":411,"cosmosGeoPoint":412,"geoPoint":416,"contacts":417},"Azienda Ospedaliero Universitaria Delle Marche","Ancona","60126","Italy","IT",{"type":44,"coordinates":413},[414,415],13.5103,43.60717,{"lat":415,"lon":414},[418],{"name":419,"role":32,"phone":420,"phoneExt":28,"email":28},"Erika Morsia, Dr.","+39 071 5961",{"facility":422,"status":38,"city":423,"state":28,"zip":424,"country":425,"countryCode":426,"cosmosGeoPoint":427,"geoPoint":431,"contacts":432},"Radboud University Medical Center","Nijmegen","6525","Netherlands","NL",{"type":44,"coordinates":428},[429,430],5.85278,51.8425,{"lat":430,"lon":429},[433],{"name":434,"role":32,"phone":435,"phoneExt":28,"email":28},"N.M.A. Blijlevens, Dr.","+31 (0)24 361 11 11",{"facility":437,"status":38,"city":438,"state":28,"zip":439,"country":440,"countryCode":441,"cosmosGeoPoint":442,"geoPoint":446,"contacts":447},"Szpital Specjalistycnzy im. Jedrzeja Sniadeckiego w Nowym Saczu","Nowy Sącz","33-300","Poland","PL",{"type":44,"coordinates":443},[444,445],20.69705,49.62177,{"lat":445,"lon":444},[448],{"name":449,"role":32,"phone":450,"phoneExt":28,"email":28},"Szymon Fornagiel, Dr","+48 18 443 88 77",{"facility":452,"status":38,"city":453,"state":28,"zip":454,"country":440,"countryCode":441,"cosmosGeoPoint":455,"geoPoint":459,"contacts":460},"MICS Centrum Medyczne Torun","Torun","87-100",{"type":44,"coordinates":456},[457,458],18.59814,53.01375,{"lat":458,"lon":457},[461],{"name":462,"role":32,"phone":463,"phoneExt":28,"email":28},"Dominik Chraniuk, Dr.","+48 662 062 410",{"facility":465,"status":38,"city":466,"state":28,"zip":467,"country":440,"countryCode":441,"cosmosGeoPoint":468,"geoPoint":472,"contacts":473},"Instytut Hematologii I Transfuzjologii","Warsaw","02-776",{"type":44,"coordinates":469},[470,471],21.01178,52.22977,{"lat":471,"lon":470},[474],{"name":475,"role":32,"phone":476,"phoneExt":28,"email":28},"Ewa Lech-Maranda, Dr.","+48 22 349 61 00",{"facility":478,"status":236,"city":479,"state":480,"zip":481,"country":482,"countryCode":28,"cosmosGeoPoint":483,"geoPoint":487,"contacts":28},"Chonbuk National University Hospital","Jeonju","Jeollabuk-do","54907","South Korea",{"type":44,"coordinates":484},[485,486],127.14889,35.82194,{"lat":486,"lon":485},{"facility":489,"status":236,"city":490,"state":28,"zip":491,"country":482,"countryCode":28,"cosmosGeoPoint":492,"geoPoint":496,"contacts":28},"Keimyung University Dongsan Hospital","Daegu","42601",{"type":44,"coordinates":493},[494,495],128.59111,35.87028,{"lat":495,"lon":494},{"facility":498,"status":38,"city":499,"state":28,"zip":500,"country":482,"countryCode":28,"cosmosGeoPoint":501,"geoPoint":505,"contacts":506},"Uijeongbu Eulji Medical Center","Gyeonggi-do","11749",{"type":44,"coordinates":502},[503,504],126.76917,37.58944,{"lat":504,"lon":503},[507],{"name":508,"role":32,"phone":509,"phoneExt":28,"email":28},"Dong-Wook Kim, Dr","+82 3118990001",{"facility":511,"status":236,"city":512,"state":28,"zip":513,"country":482,"countryCode":28,"cosmosGeoPoint":514,"geoPoint":518,"contacts":28},"Chonnam National University Hwasun Hospital","Hwasun","58128",{"type":44,"coordinates":515},[516,517],126.98746,35.06125,{"lat":517,"lon":516},{"facility":520,"status":236,"city":521,"state":28,"zip":522,"country":482,"countryCode":28,"cosmosGeoPoint":523,"geoPoint":527,"contacts":28},"Samsung Medical Center","Seoul","06351",{"type":44,"coordinates":524},[525,526],126.9784,37.566,{"lat":526,"lon":525},{"facility":529,"status":38,"city":530,"state":28,"zip":531,"country":532,"countryCode":533,"cosmosGeoPoint":534,"geoPoint":538,"contacts":539},"Hospital Del Mar","Barcelona","08003","Spain","ES",{"type":44,"coordinates":535},[536,537],2.15899,41.38879,{"lat":537,"lon":536},[540],{"name":541,"role":32,"phone":542,"phoneExt":28,"email":28},"Patricia Velez Tenza, Dr","+34 932 48 30 00",{"facility":544,"status":236,"city":545,"state":28,"zip":546,"country":532,"countryCode":533,"cosmosGeoPoint":547,"geoPoint":551,"contacts":28},"Hospital Universitario de Gran Canaria Dr. Negrin, Servicio Canario e Salud (SCS)","Las Palmas de Gran Canaria","35010",{"type":44,"coordinates":548},[549,550],-15.41573,28.10178,{"lat":550,"lon":549},{"facility":553,"status":38,"city":554,"state":28,"zip":555,"country":532,"countryCode":533,"cosmosGeoPoint":556,"geoPoint":560,"contacts":561},"Hospital Universitario La Paz","Madrid","28046",{"type":44,"coordinates":557},[558,559],-3.70256,40.4165,{"lat":559,"lon":558},[562],{"name":563,"role":32,"phone":564,"phoneExt":28,"email":28},"Maria Raquel de Paz Arias, Dr","+34 917 27 70 00",{"facility":566,"status":567,"city":568,"state":28,"zip":569,"country":532,"countryCode":533,"cosmosGeoPoint":570,"geoPoint":574,"contacts":28},"Complejo Hospitalario de Toledo - Hospital Virgen de la Salud","TERMINATED","Toledo","45007",{"type":44,"coordinates":571},[572,573],-4.02263,39.8581,{"lat":573,"lon":572},{"facility":576,"status":38,"city":577,"state":28,"zip":578,"country":532,"countryCode":533,"cosmosGeoPoint":579,"geoPoint":583,"contacts":584},"Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)","Valencia","46026",{"type":44,"coordinates":580},[581,582],-0.37966,39.47391,{"lat":582,"lon":581},[585],{"name":586,"role":32,"phone":587,"phoneExt":28,"email":28},"Elvira Mora Castera, Dr","+34 961 24 40 00",{"facility":589,"status":38,"city":590,"state":28,"zip":591,"country":592,"countryCode":593,"cosmosGeoPoint":594,"geoPoint":598,"contacts":599},"Beatson West of Scotland Cancer Centre, Gartnavel General Hospital","Glasgow","G12 0YN","United Kingdom","UK",{"type":44,"coordinates":595},[596,597],-4.25763,55.86515,{"lat":597,"lon":596},[600],{"name":601,"role":32,"phone":602,"phoneExt":28,"email":28},"Mhairi Copland, Dr","+44 141 301 7000",{"facility":604,"status":38,"city":605,"state":28,"zip":606,"country":592,"countryCode":593,"cosmosGeoPoint":607,"geoPoint":611,"contacts":612},"Hammersmith Hospital Imperial College Healthcare NHS Trust","London","W12 0HS",{"type":44,"coordinates":608},[609,610],-0.12574,51.50853,{"lat":610,"lon":609},[613],{"name":614,"role":32,"phone":615,"phoneExt":28,"email":28},"Dragana Milojkovic, Dr.","+44 20 3313 8335",{"facility":617,"status":38,"city":618,"state":28,"zip":619,"country":592,"countryCode":593,"cosmosGeoPoint":620,"geoPoint":624,"contacts":625},"The Christie NHS Foundation Trust","Manchester","M20 4BX",{"type":44,"coordinates":621},[622,623],-2.23743,53.48095,{"lat":623,"lon":622},[626],{"name":627,"role":32,"phone":628,"phoneExt":28,"email":28},"John Chadwick, Dr","+44 (0) 161 446 3000",{"type":630,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100462646","phase-1-a-phase-1a1b-study-of-elvn-001-for-the-treatment-chronic-myeloid-leukemia-100462646",false,"NCT05304377","A Phase 1a\u002F1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia","A Phase 1a\u002F1b Study of ELVN-001 for the Treatment of Chronic Myeloid Leukemia","CML","Inclusion Criteria:\n\n* BCR-ABL1 positive CML in chronic phase, with or without T315I mutation.\n* US: The patient has failed or is intolerant to at least one prior second-generation tyrosine kinase inhibitor (TKI) or asciminib. Rest of World: The patient has failed, is intolerant to, or not a candidate for, available therapies known to be active for treatment of their CML (country-specific criteria may vary).\n* ECOG performance status of 0 to 2.\n* Adequate hematologic, hepatic and renal function.\n* Prior bone marrow transplant allowed if ≥ 6 months prior to the first dose of ELVN-001.\n\nExclusion Criteria:\n\n* Treatment with anti-cancer or anti-CML therapy within 7 days or 5 half-lives, whichever is longer.\n* History of acute tyrosine kinase inhibitor (TKI)-related pancreatitis within 6 months of study entry. Active chronic pancreatitis, or pancreatic disease due to any cause.\n* QTc \\>470 ms.","ALL","18 Years",{"count":642,"type":643},250,"ESTIMATED","INTERVENTIONAL",[646],"PHASE1","The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in patients with chronic myeloid leukemia with and without T315I mutations in patients who are relapsed, refractory or intolerant to TKIs.",[649,650,651],"Chronic Myeloid Leukemia","Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive","Cml",[637,653,654,655,656,657,658],"Tyrosine kinase inhibitor","T315I","T315I mutant","BCR-ABL","ENABLE","active site inhibitor of BCR-ABL","2026-03-31",{"date":661,"type":662},"2026-04-01","ACTUAL",{"date":664,"type":662},"2022-05-22",{"date":666,"type":643},"2027-12",{"name":5,"class":6},45]