[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588080":3},{"organization":4,"armGroups":7,"interventions":43,"overallOfficials":49,"centralContacts":50,"locations":56,"responsibleParty":73,"collaborators":49,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":49,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":49,"enrollmentInfo":84,"targetDuration":49,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":59,"whyStopped":49,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Hansoh BioMedical R&D Company","INDUSTRY",[8,14,18,22,26,30,33,36,39],{"label":9,"type":10,"description":11,"interventionNames":12},"HS-20108 Ia","EXPERIMENTAL","Phase Ia Dose Escalation",[13],"Drug: HS-20108 Monotherapy",{"label":15,"type":10,"description":16,"interventionNames":17},"HS-20108 Ib Cohort1","Phase Ib Dose Expansion Cohort 1: Participants with small cell lung cancer will receive varying doses of HS-20108",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"HS-20108 Ib Cohort2","Phase Ib Dose Expansion Cohort 2: Participants with neuroendocrine carcinoma will receive varying doses of HS-20108",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"HS-20108 Ib Cohort3","Phase Ib Dose Expansion Cohort 3: Participants with other advanced solid tumors will receive varying doses of HS-20108",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"HS-20108 and Adebrelimab Ia&Ib","Phase Ia Dose Escalation Phase Ib Dose Expansion",[13],{"label":31,"type":10,"description":28,"interventionNames":32},"HS-20108 and SHR-7787 Ia &Ib",[13],{"label":34,"type":10,"description":28,"interventionNames":35},"HS-20108、Adebrelimab and SHR-7787 Ia &Ib",[13],{"label":37,"type":10,"description":28,"interventionNames":38},"HS-20108 and Cisplatin \u002F Carboplatin Ia&Ib",[13],{"label":40,"type":10,"description":41,"interventionNames":42},"HS-20108、Adebrelimab and Cisplatin \u002F Carboplatin Ia&Ib","Phase Ib Dose Expansion",[13],[44],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"DRUG","HS-20108 Monotherapy","Intravenous (IV) Infusion",[9,15,19,23,27,37,31,40,34],null,[51],{"name":52,"role":53,"phone":54,"phoneExt":49,"email":55},"Jie Chen, Doctor","CONTACT","+8613660217442","Chen0jie@hotmail.com",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Fudan University Shanghai Cancer Center","RECRUITING","Shanghai","Shanghai Municipality","200032","China","CN",{"type":66,"coordinates":67},"Point",[68,69],121.45806,31.22222,{"lat":69,"lon":68},[72],{"name":52,"role":53,"phone":54,"phoneExt":49,"email":55},{"type":74,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR","100588080","phase-1-a-phase-i-study-of-hs-20108-in-participants-with-advanced-solid-tumors-100588080",false,"NCT06936735","A Phase I Study of HS-20108 in Participants With Advanced Solid Tumors","A Phase I Clinical Study Evaluating Safety, Tolerability, Pharmacokinetics and Efficacy of Intravenous HS-20108 in Participants With Advanced Solid Tumors","Inclusion Criteria:\n\n1. Men or women aged more than or equal to (≥) 18 years.\n2. Participants with pathologically confirmed advanced solid tumors.\n3. At least one measurable lesion in accordance with RECIST 1.1\n4. Fresh or archival tumor tissue available for submission.\n5. Eastern Cooperative Oncology Group (ECOG) performance status: 0\\~1.\n6. Estimated life expectancy \\>12 weeks.\n7. Reproductive-age women agree to use adequate contraception and cannot breastfeed while participating in this study and for a period of 6 months after the last dose. Likewise, men also consent to use adequate contraceptive method within the same time limit.\n8. Females must have evidence of non-childbearing potential.\n9. Signed and dated Informed Consent Form.\n\nExclusion Criteria:\n\n1. Treatment with any of the following:\n\n   Having received cytotoxic chemotherapy agents, investigational drugs, Chinese medicine treatment with anti-tumor indications, or other anti-tumor therapy (including endocrine therapy, molecular targeted therapy, or biotherapy) within 14 days before the first dose of study treatment.\n\n   Having received macromolecular anti-tumor drug therapy (including immunotherapy, such as monoclonal antibody drugs and bispecific antibody drugs) within 28 days before the first dose of study treatment.\n\n   Local radiotherapy for palliation within 2 weeks of the first dose of study drug, or patients received more than 30% of the bone marrow irradiation, or large-scale radiotherapy within 4 weeks of the first dose.\n\n   Major surgery (including craniotomy, thoracotomy, or laparotomy, etc.) within 4 weeks of the first dose of study drug.\n2. Inadequate bone marrow reserve or serious organ dysfunction.\n3. Uncontrolled pleural effusion or ascites or pericardial effusion.\n4. Known and untreated, or active central nervous system metastases.\n5. Active autoimmune diseases or active infectious disease\n6. Known to have interstitial pneumonia or immune pneumonia\n7. History of severe allergic reaction, serious transfusion reactions or Allergy to any component of HS-20108\n8. The subject who is unlikely to comply with study procedures, restrictions, or requirements judged by the investigator.\n9. The subject whose safety cannot be ensured or study assessments would be interfered judged by the investigator.\n10. Pregnant women, breastfeeding women or woman who has a child-bearing plan during the study.\n11. History of neuropathy or mental disorders, including epilepsy and dementia.","ALL","18 Years",{"count":85,"type":86},502,"ESTIMATED","INTERVENTIONAL",[89],"PHASE1","This is a Phase I clinical study of HS-20108. The purpose of this study is to evaluate the safety, tolerability, PK and efficacy of intravenous HS-20108 in patients with advanced solid tumors.",[92],"Advanced Solid Tumor",[94,95],"small cell lung cancer","neuroendocrine carcinoma","2026-05-31",{"date":98,"type":99},"2026-06-02","ACTUAL",{"date":101,"type":99},"2025-05-29",{"date":103,"type":86},"2029-02-28",{"name":5,"class":6},1]