[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100277310":3},{"organization":4,"armGroups":7,"interventions":50,"overallOfficials":91,"centralContacts":95,"locations":104,"responsibleParty":149,"collaborators":152,"id":160,"slug":161,"hasResults":162,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":162,"sex":168,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":90,"studyType":174,"phases":175,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":107,"whyStopped":90,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":197},{"fullName":5,"class":6},"Shanghai Jiao Tong University School of Medicine","OTHER",[8,14,19,24,29,34,39,44],{"label":9,"type":10,"description":11,"interventionNames":12},"Carboplatin","EXPERIMENTAL","Carboplatin-based chemotherapy (Carboplatin 400mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy using Carboplatin was done for 3 cycles with 30 days after last surgery.",[13],"Drug: Carboplatin",{"label":15,"type":10,"description":16,"interventionNames":17},"Docetaxel","Docetaxel-based chemotherapy (Docetaxel 120mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy using Docetaxel was done for 3 cycles with 30 days after last surgery.",[18],"Drug: Docetaxel",{"label":20,"type":10,"description":21,"interventionNames":22},"Gemcitabine\u002FCisplatin","Gemcitabine\u002FCisplatin-based combinational chemotherapy (Gemcitabine 200mg + Cisplatin 60mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy was done for 3 cycles with 30 days after last surgery.",[23],"Drug: Gemcitabine\u002FCisplatin",{"label":25,"type":10,"description":26,"interventionNames":27},"Cisplatin","Cisplatin-based chemotherapy (Cisplatin 60mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy using Cisplatin was done for 3 cycles with 30 days after last surgery.",[28],"Drug: Cisplatin",{"label":30,"type":10,"description":31,"interventionNames":32},"Docetaxel\u002FOxaliplatin","Docetaxel\u002FOxaliplatin-based chemotherapy (Docetaxel 120mg + Oxaliplatin 200mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy was done for 3 cycles with 30 days after last surgery.",[33],"Drug: Docetaxel\u002FOxaliplatin",{"label":35,"type":10,"description":36,"interventionNames":37},"Docetaxel\u002FCarboplatin","Docetaxel\u002FCarboplatin-based chemotherapy (Docetaxel 120mg + Carboplatin 400mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy was done for 3 cycles with 30 days after last surgery.",[38],"Drug: Docetaxel\u002FCarboplatin",{"label":40,"type":10,"description":41,"interventionNames":42},"Gemcitabine\u002FCarboplatin","Gemcitabine\u002FCarboplatin-based chemotherapy (Gemcitabine 200mg + Carboplatin 400mg) was performed 30 days before surgery for patients who had previous surgery to remove the primary non-small cell lung carcinoma but suffered from the recurrent disease. The same chemotherapy was done for 3 cycles with 30 days after last surgery.",[43],"Drug: Gemcitabine\u002FCarboplatin",{"label":45,"type":46,"description":47,"interventionNames":48},"Placebo","PLACEBO_COMPARATOR","No Adjuvant chemotherapy using CCODG was done for patients who had previous surgery to remove the primary non-small cell lung carcinoma but subject to tumor relapse. Instead, placebo was supplied to these patients as a comparator Arm.",[49],"Drug: Placebo",[51,57,62,67,72,77,82,87],{"type":52,"name":25,"description":53,"armGroupLabels":54,"otherNames":55},"DRUG","Procedure: Preoperative chemotherapy using Cisplatin (60mg) as single agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[25],[56],"Platinol",{"type":52,"name":9,"description":58,"armGroupLabels":59,"otherNames":60},"Procedure: Preoperative chemotherapy using Carboplatin (400mg) as single agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[9],[61],"Paraplatin",{"type":52,"name":15,"description":63,"armGroupLabels":64,"otherNames":65},"Procedure: Preoperative chemotherapy using Docetaxel (120mg) as single agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[15],[66],"Taxotere",{"type":52,"name":40,"description":68,"armGroupLabels":69,"otherNames":70},"Procedure: Preoperative chemotherapy using Gemcitabine (200mg) and Carboplatin (400mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[40],[71],"Gemzar\u002FParaplatin",{"type":52,"name":20,"description":73,"armGroupLabels":74,"otherNames":75},"Procedure: Preoperative chemotherapy using Gemcitabine (200mg) and Cisplatin (60mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[20],[76],"Gemzar\u002FPlatinol",{"type":52,"name":30,"description":78,"armGroupLabels":79,"otherNames":80},"Procedure: Preoperative chemotherapy using Docetaxel (120mg) and Oxaliplatin (200mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[30],[81],"Taxotere\u002FEloxatin",{"type":52,"name":35,"description":83,"armGroupLabels":84,"otherNames":85},"Procedure: Preoperative chemotherapy using Docetaxel (120mg) and Carboplatin (400mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.",[35],[86],"Taxotere\u002FParaplatin",{"type":52,"name":45,"description":88,"armGroupLabels":89,"otherNames":90},"Regular placebo in replacement of agent-specific chemotherapy was supplied to these patients.",[45],null,[92],{"name":93,"affiliation":5,"role":94},"Yu Sun, Ph.D","PRINCIPAL_INVESTIGATOR",[96,100],{"name":93,"role":97,"phone":98,"phoneExt":90,"email":99},"CONTACT","86-21-54923302","sunyu@sibs.ac.cn",{"name":101,"role":97,"phone":102,"phoneExt":90,"email":103},"Weijun Ma, Ph.D","86-21-54923268","wjma@sibs.ac.cn",[105,124,138],{"facility":106,"status":107,"city":108,"state":109,"zip":110,"country":111,"countryCode":112,"cosmosGeoPoint":113,"geoPoint":118,"contacts":119},"China-Japan Union Hospital, Jilin University","RECRUITING","Changchun","Jilin","130033","China","CN",{"type":114,"coordinates":115},"Point",[116,117],125.32278,43.88,{"lat":117,"lon":116},[120],{"name":121,"role":97,"phone":122,"phoneExt":90,"email":123},"Xian-Ling Cong, M.D","86-0431-89876626","qingzhao_jilin@126.com",{"facility":125,"status":107,"city":126,"state":90,"zip":127,"country":111,"countryCode":112,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Shanghai 10th People's Hospital","Shanghai","200072",{"type":114,"coordinates":129},[130,131],121.45806,31.22222,{"lat":131,"lon":130},[134],{"name":135,"role":97,"phone":136,"phoneExt":90,"email":137},"Da Fu, Ph.D","86-15921527578","fu800da900@126.com",{"facility":139,"status":107,"city":126,"state":90,"zip":140,"country":111,"countryCode":112,"cosmosGeoPoint":141,"geoPoint":143,"contacts":144},"Shanghai Pulmonary Hospital, Tongji University School of Medicine","200433",{"type":114,"coordinates":142},[130,131],{"lat":131,"lon":130},[145],{"name":146,"role":97,"phone":147,"phoneExt":90,"email":148},"Chun-Yan Wu, M.D","86-65115006-3030","51917533@qq.com",{"type":94,"investigatorFullName":150,"investigatorTitle":151,"investigatorAffiliation":5,"oldNameTitle":90,"oldOrganization":90},"Yu Sun","Professor",[153,154,156,158],{"name":125,"class":6},{"name":155,"class":6},"Jilin University",{"name":157,"class":6},"Jiangxi Provincial Cancer Hospital",{"name":159,"class":6},"Shanghai Tongji Hospital, Tongji University School of Medicine","100277310","phase-1-a-randomised-trial-of-chemotherapy-plus-surgery-for-recurrent-non-small-cell-lung-cancer-100277310",false,"NCT02889666","A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancer","A Multi-Center and Randomized Control Trial of Cisplatin, Carboplatin, Oxaliplatin, Docetaxel and Gemcitabine Plus Surgery as Treatment for Relapsed and Refractory Non-Small Cell Lung Cancer","CCODG-NSCLC","Inclusion Criteria:\n\n* Age ≤ 75 years with histologically proven NSCLC\n* No severe major organ dysfunction\n* WHO performance status of 0 or 1\n* No prior cancer chemotherapy\n* A Clinical Stage ≥ IA (T1a, N0, M0) of lung disease but without diagnosed distant metastasis (according to the 1997 revision of the International Union Against Cancer TNM staging system) as determined by a preoperative evaluation that included a pleural computed tomography (CT) scan.\n\nExclusion Criteria:\n\n* Age ≥ 76\n* Severe major organ dysfunction\n* WHO performance status of \\>1\n* Prior cancer chemotherapy\n* Stage IV","ALL","18 Years","75 Years",{"count":172,"type":173},500,"ESTIMATED","INTERVENTIONAL",[176],"PHASE1","The purpose of this study is to determine if the commonly administered chemotherapeutic agents including cisplatin, carboplatin, oxaliplatin, docetaxel and gemcitabine for solid tumors in clinical oncology, either a single format or given as combinations followed by surgery are effective in the treatment of relapsed and refractory non-small cell lung cancer patients.",[179],"Recurrent Non-small Cell Lung Cancer",[181,182,183,184,185,186,187],"relapsed","non-small cell lung cancer","cisplatin","carboplatin","oxaliplatin","docetaxel","gemcitabine","2024-04-15",{"date":190,"type":191},"2024-04-17","ACTUAL",{"date":193,"type":90},"2008-01",{"date":195,"type":173},"2027-12",{"name":5,"class":6},3]