[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610343":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":42,"centralContacts":46,"locations":51,"responsibleParty":260,"collaborators":34,"id":262,"slug":263,"hasResults":264,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":34,"eligibilityCriteria":268,"healthyVolunteers":264,"sex":269,"minAge":270,"maxAge":34,"enrollmentInfo":271,"targetDuration":34,"studyType":274,"phases":275,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":54,"whyStopped":34,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":294},{"fullName":5,"class":6},"BeOne Medicines","INDUSTRY",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1a, Part A: Dose Escalation, BG-75098 Monotherapy","EXPERIMENTAL","Sequential cohorts of increasing dose levels of BG-75098 will be evaluated as monotherapy.",[13],"Drug: BG-75098",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1a, Part B: Dose Escalation, BG-75098 Combination","Sequential cohorts of increasing dose levels of BG-75098 will be evaluated in combination with BGB-43395 and fulvestrant.",[13,18,19],"Drug: BGB-43395","Drug: Fulvestrant",{"label":21,"type":10,"description":22,"interventionNames":23},"Phase 1b, Cohort 1: Dose Expansion, BG-75098 Combination","Participants will receive BG-75098 at the recommended dose level from Phase 1a in combination with BGB-43395 and fulvestrant.",[13,18,19],{"label":25,"type":10,"description":26,"interventionNames":27},"Phase 1b, Cohort 2: Dose Expansion, BG-75098 Monotherapy","Participants will receive BG-75098 as monotherapy at the recommended dose level from Phase 1a.",[13],[29,35,38],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","BG-75098","Administered orally.",[9,15,21,25],null,{"type":30,"name":36,"description":32,"armGroupLabels":37,"otherNames":34},"BGB-43395",[15,21],{"type":30,"name":39,"description":40,"armGroupLabels":41,"otherNames":34},"Fulvestrant","Administered by intramuscular injection.",[15,21],[43],{"name":44,"affiliation":5,"role":45},"Study Director","STUDY_DIRECTOR",[47],{"name":44,"role":48,"phone":49,"phoneExt":34,"email":50},"CONTACT","8778285568","clinicaltrials@beonemed.com",[52,66,76,86,96,102,112,124,133,143,153,162,172,184,194,204,214,220,230,240,249],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":34},"University of Alabama At Birmingham Hospital","RECRUITING","Birmingham","Alabama","35294-0004","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-86.80249,33.52066,{"lat":64,"lon":63},{"facility":67,"status":54,"city":68,"state":69,"zip":70,"country":58,"countryCode":59,"cosmosGeoPoint":71,"geoPoint":75,"contacts":34},"Yale Cancer Center","New Haven","Connecticut","06510",{"type":61,"coordinates":72},[73,74],-72.92816,41.30815,{"lat":74,"lon":73},{"facility":77,"status":54,"city":78,"state":79,"zip":80,"country":58,"countryCode":59,"cosmosGeoPoint":81,"geoPoint":85,"contacts":34},"Sidney Kimmel Comprehensive Cancer At Johns Hopkins","Baltimore","Maryland","21287",{"type":61,"coordinates":82},[83,84],-76.61219,39.29038,{"lat":84,"lon":83},{"facility":87,"status":54,"city":88,"state":89,"zip":90,"country":58,"countryCode":59,"cosmosGeoPoint":91,"geoPoint":95,"contacts":34},"The University of Texas Md Anderson Cancer Center","Houston","Texas","77030-4009",{"type":61,"coordinates":92},[93,94],-95.36327,29.76328,{"lat":94,"lon":93},{"facility":97,"status":54,"city":88,"state":89,"zip":98,"country":58,"countryCode":59,"cosmosGeoPoint":99,"geoPoint":101,"contacts":34},"Next Houston","77054",{"type":61,"coordinates":100},[93,94],{"lat":94,"lon":93},{"facility":103,"status":54,"city":104,"state":105,"zip":106,"country":58,"countryCode":59,"cosmosGeoPoint":107,"geoPoint":111,"contacts":34},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226-1222",{"type":61,"coordinates":108},[109,110],-87.90647,43.0389,{"lat":110,"lon":109},{"facility":113,"status":54,"city":114,"state":115,"zip":116,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":123,"contacts":34},"Blacktown Cancer and Haematology Centre","Blacktown","New South Wales","NSW 2148","Australia","AU",{"type":61,"coordinates":120},[121,122],150.91667,-33.76667,{"lat":122,"lon":121},{"facility":125,"status":54,"city":126,"state":115,"zip":127,"country":117,"countryCode":118,"cosmosGeoPoint":128,"geoPoint":132,"contacts":34},"Genesiscare St Leonards","St Leonards","NSW 2065",{"type":61,"coordinates":129},[130,131],151.19836,-33.82344,{"lat":131,"lon":130},{"facility":134,"status":54,"city":135,"state":136,"zip":137,"country":117,"countryCode":118,"cosmosGeoPoint":138,"geoPoint":142,"contacts":34},"Icon Cancer Centre Wesley","Auchenflower","Queensland","QLD 4066",{"type":61,"coordinates":139},[140,141],152.99213,-27.47443,{"lat":141,"lon":140},{"facility":144,"status":54,"city":145,"state":146,"zip":147,"country":117,"countryCode":118,"cosmosGeoPoint":148,"geoPoint":152,"contacts":34},"Cabrini Hospital Malvern","Malvern","Victoria","VIC 3144",{"type":61,"coordinates":149},[150,151],145.02811,-37.86259,{"lat":151,"lon":150},{"facility":154,"status":54,"city":155,"state":146,"zip":156,"country":117,"countryCode":118,"cosmosGeoPoint":157,"geoPoint":161,"contacts":34},"Peter Maccallum Cancer Centre","Melbourne","VIC 3000",{"type":61,"coordinates":158},[159,160],144.96332,-37.814,{"lat":160,"lon":159},{"facility":163,"status":54,"city":164,"state":165,"zip":166,"country":117,"countryCode":118,"cosmosGeoPoint":167,"geoPoint":171,"contacts":34},"One Clinical Research","Nedlands","Western Australia","WA 6009",{"type":61,"coordinates":168},[169,170],115.8073,-31.98184,{"lat":170,"lon":169},{"facility":173,"status":54,"city":174,"state":175,"zip":176,"country":177,"countryCode":178,"cosmosGeoPoint":179,"geoPoint":183,"contacts":34},"Cancer Hospital Chinese Academy of Medical Sciences","Beijing","Beijing Municipality","100021","China","CN",{"type":61,"coordinates":180},[181,182],116.39723,39.9075,{"lat":182,"lon":181},{"facility":185,"status":54,"city":186,"state":187,"zip":188,"country":177,"countryCode":178,"cosmosGeoPoint":189,"geoPoint":193,"contacts":34},"Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)","Guangzhou","Guangdong","510245",{"type":61,"coordinates":190},[191,192],113.25,23.11667,{"lat":192,"lon":191},{"facility":195,"status":54,"city":196,"state":197,"zip":198,"country":177,"countryCode":178,"cosmosGeoPoint":199,"geoPoint":203,"contacts":34},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang","150000",{"type":61,"coordinates":200},[201,202],126.65,45.75,{"lat":202,"lon":201},{"facility":205,"status":54,"city":206,"state":207,"zip":208,"country":177,"countryCode":178,"cosmosGeoPoint":209,"geoPoint":213,"contacts":34},"Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology","Wuhan","Hubei","430030",{"type":61,"coordinates":210},[211,212],114.26667,30.58333,{"lat":212,"lon":211},{"facility":215,"status":54,"city":206,"state":207,"zip":216,"country":177,"countryCode":178,"cosmosGeoPoint":217,"geoPoint":219,"contacts":34},"Union Hospital Tongji Medical College Huazhong University of Science and Technologyjinyinhu Branch","430048",{"type":61,"coordinates":218},[211,212],{"lat":212,"lon":211},{"facility":221,"status":54,"city":222,"state":223,"zip":224,"country":177,"countryCode":178,"cosmosGeoPoint":225,"geoPoint":229,"contacts":34},"Jiangsu Province Hospital Longjiang Branch","Nanjing","Jiangsu","210036",{"type":61,"coordinates":226},[227,228],118.77778,32.06167,{"lat":228,"lon":227},{"facility":231,"status":54,"city":232,"state":233,"zip":234,"country":177,"countryCode":178,"cosmosGeoPoint":235,"geoPoint":239,"contacts":34},"Qilu Hospital of Shandong University","Jinan","Shandong","250000",{"type":61,"coordinates":236},[237,238],116.99722,36.66833,{"lat":238,"lon":237},{"facility":241,"status":54,"city":242,"state":233,"zip":243,"country":177,"countryCode":178,"cosmosGeoPoint":244,"geoPoint":248,"contacts":34},"Weifang Peoples Hospital","Weifang","261000",{"type":61,"coordinates":245},[246,247],119.10194,36.71,{"lat":247,"lon":246},{"facility":250,"status":54,"city":251,"state":34,"zip":252,"country":253,"countryCode":254,"cosmosGeoPoint":255,"geoPoint":259,"contacts":34},"Rigshospitalet","Copenhagen","2100","Denmark","DK",{"type":61,"coordinates":256},[257,258],12.56553,55.67594,{"lat":258,"lon":257},{"type":261,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100610343","phase-1-a-study-of-bg-75098-alone-and-in-combination-with-other-agents-in-adults-with-advanced-solid-tumors-100610343",false,"NCT07226349","A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors","A Phase 1a\u002F1b, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BG-75098 Alone and in Combination With Other Agents in Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n* Participants must have measurable disease as assessed by RECIST v1.1.\n* Participants must have a stable Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.\n* Participants must have adequate organ function.\n* Dose Escalation Part A: Participants with histologically or cytologically confirmed advanced, metastatic, or unresectable solid tumors potentially associated with cyclin-dependent kinase 2 (CDK2) dependency. Participants should have received prior treatment with available standard-of-care (SOC) systemic therapies for advanced\u002Fmetastatic disease, or for whom standard therapy is not available or not tolerated.\n* Dose Escalation Part B: Patients with histologically or cytologically confirmed advanced, metastatic, or unresectable solid tumors who have received ≥ 1 prior line of systemic therapy in the metastatic setting.\n* Dose Expansion Cohort 1: Participants with histologically or cytologically confirmed advanced, metastatic, or unresectable CDK4\u002F6 inhibitor-progressed solid tumors.\n* Dose Expansion Cohort 2: Participants with advanced solid tumors. Participants with primary platinum refractory disease are not eligible. Participants should have received ≥ 1 line of platinum-containing chemotherapy and ≤ 4 prior therapeutic regimens in the advanced\u002Fmetastatic setting.\n\nExclusion Criteria:\n\n* For all cohorts: Prior therapy selectively targeting CDK2 inhibition or degradation.\n* For combination cohorts: Prior therapy selectively targeting CDK4. Prior CDK4\u002F6 inhibitor standard of care therapy is permitted and required in local regions where it is approved and available.\n* Participants with active leptomeningeal disease or uncontrolled, untreated brain metastasis.\n\nNOTE: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":272,"type":273},105,"ESTIMATED","INTERVENTIONAL",[276],"PHASE1","The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75098 alone and in combination with BGB-43395 and fulvestrant in participants with advanced solid tumors.",[279],"Advanced Solid Tumor",[281,282,283,284],"Cyclin-Dependent Kinase 2- Targeted Protein Degrader","CDK2","CDK4","CDK4 inhibitor","2026-06-01",{"date":287,"type":288},"2026-06-03","ACTUAL",{"date":290,"type":288},"2025-12-11",{"date":292,"type":273},"2028-11-01",{"name":5,"class":6},21]