[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540777":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":24,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":24,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":24,"overallStatus":39,"whyStopped":24,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Jemincare","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dose Escalation","EXPERIMENTAL","Subjects will be assigned to pre-specified dose level to determine MTD\u002FMAD of JMKX003948. Each treatment cycle will be 21 days.",[13],"Drug: JMKX003948",{"label":15,"type":10,"description":16,"interventionNames":17},"Dose Expansion","Subjects will be assigned to the recommended dose level determined in dose escalation Phase. Each treatment cycle will be 21 days.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","JMKX003948","Subjects will receive JMKX003948 tablets until disease progression",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Jun Guo","Peking University Cancer Hospital & Institute","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Huihui Xiang","CONTACT","+86 15928607671","xianghuihui@jemincare.com",[37],{"facility":38,"status":39,"city":40,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Beijing Caancer Hospital","RECRUITING","Beijing","China","CN",{"type":44,"coordinates":45},"Point",[46,47],116.39723,39.9075,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":24,"phoneExt":24,"email":24},"Jun Guo, Master",{"type":53,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[55],{"name":56,"class":6},"Zhejiang Hangyu Pharmaceutical Co., Ltd.","100540777","phase-1-a-study-of-jmkx003948-tablets-in-patients-with-renal-cell-carcinoma-100540777",false,"NCT06321250","A Study of JMKX003948 Tablets in Patients With Renal Cell Carcinoma","An Open-label, Multicenter Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of JMKX003948 Tablets in Patients With Renal Cell Carcinoma","Inclusion Criteria:\n\n1. Has the ability to understand and willingness to sign a written informed consent form.\n2. Male or female from 18 years of age or older.\n3. Histologically confirmed locally advanced or metastasis clear cell renal cell carcinoma.\n4. Has at least one measurable lesion per RECIST v1.1.\n5. Has a life expectancy of ≥ 12 weeks.\n6. Adequate organ function.\n\nExclusion Criteria:\n\n1. Patients with known active CNS metastases and\u002For cancerous meningitis.\n2. Has received any type of systemic anticancer monoclonal antibodies or other immunosuppressants within 4 weeks prior to the first dose. Has received prior chemotherapy, targeted therapy, or other investigational therapy within 2 weeks prior to the first dose.\n3. Has failed to recover from a ≥ grade 2 adverse event due to prior anti-tumor therapy.\n4. Has impaired heart function,or clinically significant cerebrovascular and cardiovascular disease.\n5. Subjects with dysphagia or known drug absorption disorders.\n6. Has a history of any other malignancy within 5 years.\n7. Has severe oncological complications.\n8. Is currently participating in other clinical studies.\n9. Subjects with be unsuitable for participation in the trial evaluated by investigator.","ALL","18 Years",{"count":67,"type":68},80,"ESTIMATED","INTERVENTIONAL",[71],"PHASE1","This open-label Phase 1 study will evaluate the safety, tolerability, PK characteristics and preliminarily efficacy of JMKX003948 tablets in patients with renal cell carcinoma.",[74],"Renal Cell Carcinoma Metastatic","2024-07-06",{"date":77,"type":78},"2024-07-09","ACTUAL",{"date":80,"type":78},"2024-03-14",{"date":82,"type":68},"2027-04-30",{"name":5,"class":6},1]