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l'Archet","Nice","06200",{"type":60,"coordinates":723},[724,725],7.26608,43.70313,{"lat":725,"lon":724},[728],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":730,"status":53,"city":731,"state":11,"zip":732,"country":688,"countryCode":689,"cosmosGeoPoint":733,"geoPoint":737,"contacts":738},"Institut de cancerologie du Gard","Nîmes","30029",{"type":60,"coordinates":734},[735,736],4.35788,43.83665,{"lat":736,"lon":735},[739],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":730,"status":53,"city":731,"state":11,"zip":11,"country":688,"countryCode":689,"cosmosGeoPoint":741,"geoPoint":743,"contacts":744},{"type":60,"coordinates":742},[735,736],{"lat":736,"lon":735},[745],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":747,"status":53,"city":748,"state":11,"zip":749,"country":688,"countryCode":689,"cosmosGeoPoint":750,"geoPoint":754,"contacts":755},"Hospital Saint Louis","Paris","75010",{"type":60,"coordinates":751},[752,753],2.3488,48.85341,{"lat":753,"lon":752},[756],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":758,"status":53,"city":759,"state":11,"zip":760,"country":688,"countryCode":689,"cosmosGeoPoint":761,"geoPoint":765,"contacts":766},"University Hospital of Poitiers","Poitiers","86021",{"type":60,"coordinates":762},[763,764],0.34348,46.58261,{"lat":764,"lon":763},[767],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":769,"status":53,"city":770,"state":11,"zip":771,"country":688,"countryCode":689,"cosmosGeoPoint":772,"geoPoint":776,"contacts":777},"Institut Gustave Roussy","Villejuif","94805",{"type":60,"coordinates":773},[774,775],2.35992,48.7939,{"lat":775,"lon":774},[778],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":780,"status":53,"city":781,"state":11,"zip":782,"country":783,"countryCode":784,"cosmosGeoPoint":785,"geoPoint":789,"contacts":790},"Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo","Alessandria","15121","Italy","IT",{"type":60,"coordinates":786},[787,788],8.61007,44.90924,{"lat":788,"lon":787},[791],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":793,"status":53,"city":794,"state":11,"zip":795,"country":783,"countryCode":784,"cosmosGeoPoint":796,"geoPoint":800,"contacts":11},"Istituto Nazionale Tumori, IRCCS Centro di Riferimento Oncologico di Aviano","Aviano","33081",{"type":60,"coordinates":797},[798,799],12.59472,46.07056,{"lat":799,"lon":798},{"facility":802,"status":53,"city":803,"state":11,"zip":804,"country":783,"countryCode":784,"cosmosGeoPoint":805,"geoPoint":809,"contacts":810},"IRCCS Azienda Ospedaliero -Universitaria Di Bologna - Dipartimento Malattie Oncologiche ed Ematologiche - UO Ematologia","Bologna","40138",{"type":60,"coordinates":806},[807,808],11.33875,44.49381,{"lat":808,"lon":807},[811],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":813,"status":53,"city":814,"state":11,"zip":11,"country":783,"countryCode":784,"cosmosGeoPoint":815,"geoPoint":819,"contacts":820},"ASST - Spedali Civili di Brescia","Brescia",{"type":60,"coordinates":816},[817,818],10.21472,45.53558,{"lat":818,"lon":817},[821],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":823,"status":53,"city":824,"state":11,"zip":825,"country":783,"countryCode":784,"cosmosGeoPoint":826,"geoPoint":830,"contacts":831},"IRCCS istituto Romagnolo per lo studio dei tumori \"Dino Amadori\"","Meldola","47014",{"type":60,"coordinates":827},[828,829],12.0626,44.12775,{"lat":829,"lon":828},[832],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":834,"status":53,"city":835,"state":11,"zip":836,"country":783,"countryCode":784,"cosmosGeoPoint":837,"geoPoint":841,"contacts":842},"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","Milan","20122",{"type":60,"coordinates":838},[839,840],9.18951,45.46427,{"lat":840,"lon":839},[843],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":845,"status":53,"city":846,"state":11,"zip":847,"country":783,"countryCode":784,"cosmosGeoPoint":848,"geoPoint":852,"contacts":853},"Azienda Ospedaliera Universitaria Citta' Della Salute E della Scienza di Torino","Torino","10126",{"type":60,"coordinates":849},[850,851],11.99138,44.88856,{"lat":851,"lon":850},[854],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":856,"status":53,"city":857,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":860,"geoPoint":864,"contacts":865},"Aichi Medical University Hospital","Aichi","Japan","JP",{"type":60,"coordinates":861},[862,863],130.62158,32.51879,{"lat":863,"lon":862},[866],{"name":867,"role":44,"phone":868,"phoneExt":11,"email":869},"Akiyoshi Takami","0561-62-3311","takami.akiyoshi.490@mail.aichi-med-u.ac.jp",{"facility":871,"status":53,"city":872,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":873,"geoPoint":877,"contacts":878},"Aomori Prefectural Central Hospital","Aomori",{"type":60,"coordinates":874},[875,876],140.73333,40.81667,{"lat":876,"lon":875},[879],{"name":880,"role":44,"phone":881,"phoneExt":11,"email":882},"Tomoaki Akagi, MD","017-726-8111","tomakagi@med.pref.aomori.jp",{"facility":884,"status":53,"city":885,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":886,"geoPoint":890,"contacts":891},"National Cancer Center Hospital East","Chiba",{"type":60,"coordinates":887},[888,889],140.11667,35.6,{"lat":889,"lon":888},[892],{"name":893,"role":44,"phone":894,"phoneExt":11,"email":895},"Junichiro Yuda, MD","04-7133-1111","jyuda@east.ncc.go.jp",{"facility":897,"status":53,"city":898,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":899,"geoPoint":903,"contacts":904},"Kyushu University Hospital","Fukuoka",{"type":60,"coordinates":900},[901,902],130.41667,33.6,{"lat":902,"lon":901},[905],{"name":906,"role":44,"phone":907,"phoneExt":11,"email":908},"Takuji Yamauchi, MD","092-641-1151","yamauchi.takuji.355@m.kyushu-u.ac.jp",{"facility":910,"status":53,"city":911,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":11,"geoPoint":11,"contacts":912},"Hokkaido University Hospital","Hokkaido",[913],{"name":914,"role":44,"phone":915,"phoneExt":11,"email":916},"Takanori Teshima, MD","011-716-1161","teshima@med.hokudai.ac.jp",{"facility":918,"status":53,"city":919,"state":11,"zip":920,"country":858,"countryCode":859,"cosmosGeoPoint":921,"geoPoint":925,"contacts":926},"Shonan Kamakura General Hospital","Kamakura","247-8533",{"type":60,"coordinates":922},[923,924],139.54698,35.31085,{"lat":924,"lon":923},[927],{"name":928,"role":44,"phone":929,"phoneExt":11,"email":930},"Tomiteru Togano, MD","0467-46-1717","t_togano@shonankamakura.or.jp",{"facility":932,"status":53,"city":933,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":934,"geoPoint":938,"contacts":939},"University of Miyazaki Hospital","Miyazaki",{"type":60,"coordinates":935},[936,937],131.41667,31.91667,{"lat":937,"lon":936},[940],{"name":941,"role":44,"phone":942,"phoneExt":11,"email":943},"Kazuya Shimoda, MD","0985-85-1510","kshimoda@med.miyazaki-u.ac.jp",{"facility":945,"status":53,"city":946,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":947,"geoPoint":951,"contacts":952},"Okayama University Hospital","Okayama",{"type":60,"coordinates":948},[949,950],133.93333,34.65,{"lat":950,"lon":949},[953],{"name":954,"role":44,"phone":955,"phoneExt":11,"email":956},"Noboru Asada, MD","086-223-7151","nasada@okayama-u.ac.jp",{"facility":958,"status":53,"city":959,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":960,"geoPoint":964,"contacts":965},"The University of Osaka Hospital","Osaka",{"type":60,"coordinates":961},[962,963],135.50107,34.69379,{"lat":963,"lon":962},[966],{"name":967,"role":44,"phone":968,"phoneExt":11,"email":11},"Michiko Ichii, MD","06-6879-5111",{"facility":970,"status":53,"city":971,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":972,"geoPoint":976,"contacts":977},"Saitama Medical Center","Saitama",{"type":60,"coordinates":973},[974,975],139.65657,35.90807,{"lat":975,"lon":974},[978],{"name":979,"role":44,"phone":980,"phoneExt":11,"email":981},"Takayuki Tabayashi","049-228-3411","ttabaya@saitama-med.ac.jp",{"facility":983,"status":53,"city":984,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":985,"geoPoint":989,"contacts":990},"Tohoku University Hospital","Sendai",{"type":60,"coordinates":986},[987,988],140.86667,38.26667,{"lat":988,"lon":987},[991],{"name":992,"role":44,"phone":993,"phoneExt":11,"email":11},"Noriko Fukuhara, MD","022-717-7000",{"facility":995,"status":158,"city":996,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":997,"geoPoint":1001,"contacts":11},"Shizuoka Cancer Center","Shizuoka",{"type":60,"coordinates":998},[999,1000],138.38333,34.98333,{"lat":1000,"lon":999},{"facility":1003,"status":53,"city":1004,"state":11,"zip":1005,"country":858,"countryCode":859,"cosmosGeoPoint":1006,"geoPoint":1010,"contacts":1011},"Tokyo Medical University Hospital","Tokyo","160-0023",{"type":60,"coordinates":1007},[1008,1009],139.69171,35.6895,{"lat":1009,"lon":1008},[1012],{"name":1013,"role":44,"phone":1014,"phoneExt":11,"email":1015},"Daigo Akahane, MD","03-3342-6111","dakahane@tokyo-med.ac.jp",{"facility":1017,"status":53,"city":1004,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":1018,"geoPoint":1020,"contacts":1021},"Juntendo University Hospital",{"type":60,"coordinates":1019},[1008,1009],{"lat":1009,"lon":1008},[1022],{"name":1023,"role":44,"phone":1024,"phoneExt":11,"email":1025},"Shuichi Shirane, MD","03-3813-3111","sshirane@juntendo.ac.jp",{"facility":1027,"status":53,"city":1028,"state":11,"zip":11,"country":858,"countryCode":859,"cosmosGeoPoint":1029,"geoPoint":1033,"contacts":1034},"Mie University Hospital","Tsu",{"type":60,"coordinates":1030},[1031,1032],136.51667,34.73333,{"lat":1032,"lon":1031},[1035],{"name":1036,"role":44,"phone":1037,"phoneExt":11,"email":1038},"Yuka Sugimoto, MD","059-232-1111","yuka2@clin.medic.mie-u.ac.jp",{"facility":1040,"status":53,"city":1041,"state":11,"zip":11,"country":1042,"countryCode":1043,"cosmosGeoPoint":1044,"geoPoint":1048,"contacts":1049},"Lincoln County Hospital","Lincoln","United Kingdom","UK",{"type":60,"coordinates":1045},[1046,1047],-0.53792,53.22683,{"lat":1047,"lon":1046},[1050],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":1052,"status":53,"city":1041,"state":11,"zip":11,"country":1042,"countryCode":1043,"cosmosGeoPoint":1053,"geoPoint":1055,"contacts":1056},"United Lincolnshire Hospitals NHS Trust - Pilgrim Hospital",{"type":60,"coordinates":1054},[1046,1047],{"lat":1047,"lon":1046},[1057],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":1059,"status":53,"city":1060,"state":11,"zip":11,"country":1042,"countryCode":1043,"cosmosGeoPoint":1061,"geoPoint":1065,"contacts":1066},"University College London Hospital's NHS foundation Trust","London",{"type":60,"coordinates":1062},[1063,1064],-0.12574,51.50853,{"lat":1064,"lon":1063},[1067],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"facility":1069,"status":53,"city":1070,"state":11,"zip":11,"country":1042,"countryCode":1043,"cosmosGeoPoint":1071,"geoPoint":1075,"contacts":1076},"Oxford University Hospitals NHS Foundation","Oxford",{"type":60,"coordinates":1072},[1073,1074],-1.25596,51.75222,{"lat":1074,"lon":1073},[1077],{"name":428,"role":44,"phone":11,"phoneExt":11,"email":11},{"type":1079,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100376029","phase-1-a-study-of-oral-nuvisertib-tp-3654-in-patients-with-myelofibrosis-100376029",false,"NCT04176198","A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis","A Phase 1\u002F2, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral Nuvisertib (TP-3654) in Patients With Intermediate or High-Risk Primary or Secondary Myelofibrosis","Patients must meet all of the following inclusion criteria to be eligible:\n\nNuvisertib (TP-3654) Monotherapy Arm:\n\n* Confirmed pathological diagnosis of primary myelofibrosis (PMF) or post-PV-MF\u002Fpost-ET- MF and intermediate or high-risk primary or secondary MF\n* Previously treated with JAK inhibitor(s) and is intolerant, resistant, refractory or has lost response to the JAK inhibitor(s) or is ineligible to be treated with JAK inhibitor\n* Fulfill the following clinical laboratory parameters:\n* Platelet count ≥ 25 x 10\\^9 \u002FL, without assistance of growth factors or platelet transfusions\n* ANC ≥ 1 x 10\\^9\u002FL without assistance of granulocyte growth factors\n* Peripheral blood blast count \\\u003C 5%\n* ECOG performance status ≤ 1\n* Life expectancy ≥ 6 months\n* Adequate renal function\n* Adequate hepatic function\n* Adequate coagulation function\n* Splenomegaly (spleen volume of ≥ 450 cm3 by MRI or CT scan) within 2 weeks prior to Cycle 1 Day 1.\n* Dose escalation: At least 2 symptoms measurable (score ≥ 1) using the MF-SAF\n* Dose expansion: At least 2 symptoms measurable with each score of ≥ 3 or a total average score of ≥ 10 per MFSAF\n\nNuvisertib (TP-3654) + Ruxolitinib Arm:\n\n* Confirmed pathological diagnosis of PMF or post-PV-MF\u002Fpost ET- MF and intermediate or high-risk primary or secondary MF\n* On ruxolitinib treatment for ≥ 6 months, and on a stable dose of ruxolitinib (5 to 25 mg BID) for ≥ 8 weeks prior to the first dose of nuvisertib, but has either lost response or had a suboptimal or plateau in response\n* Fulfills the following clinical laboratory parameters:\n* Platelet count ≥ 50 × 10\\^9\u002FL (without assistance of growth factors or platelet transfusions)\n* ANC ≥ 1 × 109\u002FL without assistance of granulocyte growth factors\n* Peripheral blood blast count \\\u003C 5% at screening\n* Adequate renal function\n* Adequate hepatic function\n* Adequate coagulation function\n* Splenomegaly (spleen volume of ≥ 450 cm3 by MRI\u002FCT scan) within 2 weeks prior to Cycle 1 Day 1\n* At least 2 symptoms measurable with each score ≥ 3 or a total average score of ≥ 10 per MFSAF v4.0\n* ECOG performance status ≤ 1\n* Life expectancy ≥ 6 months\n\nNuvisertib (TP-3654) + Momelotinib Arm\n\n* Confirmed pathological diagnosis of PMF or post-PV-MF\u002Fpost ET-MF and intermediate or high-risk primary or secondary MF\n* Previously treated with an approved JAK inhibitor (except momelotinib) for PMF or Post-PV\u002FET MF for ≥ 12 weeks, or ≥ 4 weeks if JAK inhibitor therapy was complicated by a transfusion requirement of ≥ 4 units of red blood cells in 8 weeks, or Grade 3\u002F4 AEs of thrombocytopenia, anemia, or hematoma\n* Fulfills the following clinical laboratory parameters:\n* Anemic, defined as Hb \\\u003C10 g\u002FdL or requiring RBC transfusion at baseline\n* Platelet count ≥ 50 × 109\u002FL (without assistance of growth factors or platelet transfusions)\n* ANC ≥ 1 × 109\u002FL without assistance of granulocyte growth factors\n* Peripheral blood blast count \\\u003C 5% at screening\n* Adequate renal function\n* Adequate hepatic function\n* Adequate coagulation function\n* Splenomegaly (spleen volume of ≥ 450 cm3 by MRI\u002FCT scan) within 2 weeks prior to Cycle 1 Day 1\n* At least 2 symptoms measurable with each score of ≥ 3 or a total average score of ≥ 10 per MFSAF v4.0\n* ECOG performance status ≤ 1\n* Life expectancy ≥ 6 months\n\nPatients meeting any one of these exclusion criteria will be prohibited from participating in this study:\n\nNuvisertib (TP-3654) Monotherapy Arm:\n\n* Received previous systemic antineoplastic therapy or any experimental therapy within 2 weeks or 5 half-lives, whichever is longer, prior to Cycle 1 Day 1. Hydroxyurea or anagrelide are allowed up to 24 hours prior to Cycle 1 Day 1).\n* Major surgery within 4 weeks prior to Cycle 1 Day 1 and\u002For not recovered adequately from from surgery prior to first dose.\n* Splenic irradiation within 6 months prior to Screening or prior splenectomy.\n* Prior allogeneic stem cell transplant within the last 6 months.\n* Eligible for allogeneic bone marrow or stem cell transplantation.\n* Unresolved Grade ≥ 2 non-hematological toxicity related to prior treatment\n* History of symptomatic congestive heart failure, or myocardial infarction, or uncontrolled arrhythmia within 6 months prior to Cycle 1 Day 1; left ventricular ejection fraction (LVEF) \\\u003C 45% by echocardiogram within 4 weeks prior to Cycle 1 Day 1.\n* Corrected QT interval \\> 480msec.\n* Prior or concurrent malignancy that could interfere with the investigational regime.\n* Known history of chronic liver disease, e.g. portal hypertension or any of its complications, cirrhosis, Child-Pugh C, auto-immune hepatitis, alpha-1 anti-trypsin deficiency, Wilson's disease, etc.\n* Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic antimicrobial within 1 week prior to Cycle 1 Day 1.\n* Chronic active or acute viral hepatitis A, B, or C infection (testing for hepatitis B and C are required)\n* Exhibited allergic reactions or sensitivity to nuvisertib, or similar compound.\n* Medical condition or GI tract surgery that could impair absorption or result in short bowel syndrome with diarrhea.\n* Systemic steroid therapy (\\>10 mg daily prednisone or equivalent) within 1 week prior to the first dose of study treatment (note: topical, inhaled, nasal, and ophthalmic steroids are not prohibited).\n* Known clinically significant anemia due to iron, vitamin B12, or folate deficiencies, or autoimmune or hereditary hemolytic anemia, or thalassemia, or severe GI bleeding.\n* Pregnant or breastfeeding\n* Currently receiving any other investigational agent.\n\nNuvisertib (TP-3654) + Ruxolitinib Arm:\n\n* Received previous systemic antineoplastic therapy (other than ruxolitinib) or any other experimental therapy within 2 weeks or 5 half-lives, whichever is longer, prior to Cycle 1 Day 1 (Note: Prior treatment with nuvisertib is not allowed. Hydroxyurea or anagrelide are allowed up to 24 hours prior to Cycle 1 Day 1).\n* Received systemic steroid therapy (\\>10 mg daily prednisone or equivalent) within 1 week prior to Cycle 1 Day 1 (Note: Topical, inhaled, nasal, and ophthalmic steroids are not prohibited)\n* Known allergic reactions or sensitivity to nuvisertib, or similar compound.\n* Splenic irradiation within 6 months prior to Screening or prior splenectomy\n* Prior allogeneic stem cell transplant within the last 6 months (Note: Patients who have relapsed after 6 months post-transplant and do not have active GVHD are eligible).\n* Eligible for allogeneic bone marrow or stem cell transplantation (Note: Patients who are not willing to undergo transplantation or for whom a suitable donor is not available are considered as transplant ineligible.)\n* Major surgery within 4 weeks prior to Cycle 1 Day 1 and\u002For have not recovered adequately prior to first dose.\n* Active, uncontrolled bacterial, viral, or fungal infections, requiring parenteral antimicrobial within 1 week prior to Cycle 1 Day 1\n* Chronic active or acute viral hepatitis A, B, or C infection (testing for hepatitis B and C are required)\n* Known history of chronic liver disease (eg, portal hypertension or any of its complications, cirrhosis, Child-Pugh C, auto-immune hepatitis, alpha-1 anti-trypsin deficiency, Wilson's disease, etc) (Note: Abnormal liver morphology at baseline imaging may require additional testing, as needed).\n* Unresolved Grade ≥ 2 non-hematological adverse events related to prior treatment (stable Grade 2 conditions may be permitted in consultation with the Sponsor)\n* History of myocardial infarction or symptomatic congestive heart failure or uncontrolled arrhythmia within 6 months prior to Cycle 1 Day 1; LVEF \\\u003C45% by echocardiogram within 4 weeks prior to Cycle 1 Day 1\n* Corrected QTcF of \\> 480 msec\n* Prior or concurrent malignancy that could interfere with the safety or efficacy assessment of the study intervention\n* History of a medical condition or GI tract surgery that could impair absorption or could result in short bowel syndrome with diarrhea\n* Known clinically significant anemia due to iron, vitamin B12, or folate deficiencies, or autoimmune or hereditary hemolytic anemia, or thalassemia, or severe GI bleeding\n* Pregnant or breastfeeding\n\nNuvisertib (TP-3654) + Momelotinib Arm:\n\n* Received previous systemic antineoplastic therapy or any experimental therapy within 2 weeks or 5 half-lives, whichever is longer, prior to Cycle 1 Day 1 (Notes: Prior treatment with momelotinib or nuvisertib is not allowed; in patients with ongoing JAK inhibitor therapy, ie, ruxolitinib, at screening, JAK inhibitor therapy must be tapered over a period of at least 1 week. Patients on a low dose of ruxolitinib (eg, 5 mg QD) may have a reduced taper period or no taper; hydroxyurea or anagrelide are allowed up to 24 hours prior to Cycle 1 Day 1).\n* Received systemic steroid therapy (\\>10 mg daily prednisone or equivalent) within 1 week prior to Cycle 1 Day 1 (Note: Topical, inhaled, nasal, and ophthalmic steroids are not prohibited).\n* Known allergic reactions or sensitivity to nuvisertib, momelotinib, or any structurally similar drug, or to any component of the formulations of either study intervention\n* Splenic irradiation within 6 months prior to screening or prior splenectomy\n* Prior allogenic stem cell transplant within the last 6 months (Note: Patients who have relapsed after 6 months post-transplant and do not have active GVHD are eligible).\n* Eligible for allogeneic bone marrow or stem cell transplantation (Note: Patients who are not willing to undergo transplantation or for whom a suitable donor is not available are considered as transplant ineligible).\n* Major surgery within 4 weeks prior to Cycle 1 Day 1 and\u002For have not recovered adequately from surgery prior to first dose.\n* Active, uncontrolled bacterial, viral, or fungal infections, requiring parenteral antimicrobial within 1 week prior to Cycle 1 Day 1\n* Chronic active or acute viral hepatitis A, B, or C infection (testing for hepatitis B and C are required)\n* Known history of chronic liver disease (eg, portal hypertension or any of its complications, cirrhosis, Child-Pugh C, auto-immune hepatitis, alpha-1 anti-trypsin deficiency, Wilson's disease, etc) (Note: Abnormal liver morphology at baseline imaging may require additional testing, as needed)\n* Unresolved Grade ≥ 2 non-hematological adverse events related to prior treatment (stable Grade 2 conditions may be permitted in consultation with the Sponsor)\n* Presence of Grade ≥ 2 peripheral neuropathy\n* History of myocardial infarction or symptomatic congestive heart failure or uncontrolled arrhythmia within 6 months prior to Cycle 1 Day 1; LVEF \\\u003C 45% by echocardiogram within 4 weeks prior to Cycle 1 Day 1\n* Corrected QTcF of \\> 480 msec\n* Prior or concurrent malignancy that could interfere with the safety or efficacy assessment of the study intervention\n* History of a medical condition or GI tract surgery that could impair absorption or could result in short bowel syndrome with diarrhea\n* Known clinically significant anemia due to iron, vitamin B12, or folate deficiencies, or autoimmune or hereditary hemolytic anemia, or thalassemia, or severe GI bleeding\n* Pregnant or breastfeeding","ALL","18 Years",{"count":1090,"type":1091},240,"ESTIMATED","INTERVENTIONAL",[1094,1095],"PHASE1","PHASE2","This study is a Phase 1\u002F2, multicenter, dose-escalation, open-label trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of nuvisertib (TP-3654) in patients with intermediate or high-risk primary or secondary MF.",[1098],"Myelofibrosis","2026-04-30",{"date":1101,"type":1102},"2026-05-01","ACTUAL",{"date":1104,"type":1102},"2019-12-16",{"date":1106,"type":1091},"2030-04-30",{"name":5,"class":6},84]