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Participants with endocrine-related AEs who are adequately treated with hormone replacement or participants who have Grade ≤2 neuropathy are eligible. Participants with Grade ≤2 alopecia are also eligible\n* Hepatitis B surface antigen (HBsAg) positive participants are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load\n* Participants with a history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has a history of (noninfectious) interstitial lung disease (ILD)\u002Fpneumonitis that required steroids or has current ILD\u002Fpneumonitis, and\u002For suspected ILD\u002Fpneumonitis that cannot be ruled out by standard diagnostic assessments\n* Has clinically severe respiratory compromise resulting from intercurrent pulmonary illness\n* Has a history of solid organ transplant\n* Has a history of allogeneic stem cell transplant\n* Has clinically significant corneal disease\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis\u002Fleptomeningeal disease; participants with previously treated brain metastases may participate provided they are radiologically stable (ie, without evidence of progression) for at least 4 weeks\n* Has uncontrolled or significant cardiovascular disorder\n* Has a history of clinically significant congenital cardiac syndrome\n* Has a history of human immunodeficiency virus (HIV) infection\n* Has a known additional malignancy that is progressing or has required active treatment within the past 1 year\n* Has an active infection requiring systemic therapy\n* Has concurrent active hepatitis B (HBsAg positive and\u002For detectable HBV deoxyribonucleic acid \\[DNA\\]) and HCV defined as anti-HCV antibody (Ab) positive and detectable HCV ribonucleic acid \\[RNA\\]) infection\n* Has not adequately recovered from major surgery or have ongoing surgical complications","ALL","1 Month","17 Years",{"count":853,"type":854},50,"ESTIMATED","INTERVENTIONAL",[857,858],"PHASE1","PHASE2","Researchers are looking for new ways to treat children with hepatoblastoma or rhabdomyosarcoma (RMS) that has relapsed or is refractory:\n\n* Hepatoblastoma is a common liver cancer in babies and very young children\n* RMS is a cancer that starts in muscle cells, often in a child's head and neck, bladder, arms, or legs\n* Relapsed means the cancer came back after treatment\n* Refractory means the cancer did not respond (get smaller or go away) to treatment\n\nThe study treatment HER3-DXd (also known as MK-1022 or patritumab deruxtecan) is an antibody-drug conjugate (ADC). 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