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Splenectomy is considered a line of therapy\n* Have relapsed or treatment-resistant primary ITP, with no available therapies known to provide clinical benefit\n* Have a platelet count less than 30,000\u002FμL on 2 occasions at least 5 days apart in the 15 days before randomization\n* Have adequate liver, renal, and hematologic functions as defined by a table\n* Are willing to follow contraception requirements\n\nExclusion Criteria:\n\n* Have a history of any thrombotic or embolic event within 12 months before screening\n* Had a transfusion with blood or blood products or plasmapheresis within 14 days (Phase 1) or within 28 days (Phase 2) of randomization\n* Have significant cardiovascular disease\n* Have a diagnosis or history of hematologic malignancy\n* Have hepatitis B virus (HBV) defined as positive for antigen of hepatitis B (HBsAg) or polymerase chain reaction (PCR) positive for HBV deoxyribonucleic acid (DNA)\n* Have hepatitis C virus (HCV) defined as positive for anti-HCV antibodies and PCR positive for HCV ribonucleic acid (RNA)","ALL","18 Years",{"count":482,"type":483},68,"ESTIMATED","INTERVENTIONAL",[486,487],"PHASE1","PHASE2","The purpose of the phase 1 part of this study was to evaluate how well pirtobrutinib is tolerated and what side effects may occur. 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