[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578155":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":119,"collaborators":121,"id":125,"slug":126,"hasResults":127,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":35,"eligibilityCriteria":131,"healthyVolunteers":127,"sex":132,"minAge":133,"maxAge":35,"enrollmentInfo":134,"targetDuration":35,"studyType":137,"phases":138,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":43,"whyStopped":35,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":158},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DCOI naïve","EXPERIMENTAL","Will receive the standard dose of sotorasib.",[13],"Drug: Sotorasib",{"label":15,"type":16,"description":17,"interventionNames":18},"Progressed on the DCOI","ACTIVE_COMPARATOR","Will continue to receive the sotorasib dose they were previously receiving, according to their doctor's instruction.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Sotorasib","Enrolled patients will be administered DCOI at the FDA-recommended dose or continued on the DCOI at the discretion of the treating Oncologist per standard of care",[9,15],[26],"AMG 510",[28],{"name":29,"affiliation":5,"role":30},"Nelson Moss, MD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","212-639-7075",null,"mossn@mskcc.org",{"name":38,"role":33,"phone":39,"phoneExt":35,"email":35},"Cameron Brennan, MD","212-639-8268",[41,57,68,80,87,98,108],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)","RECRUITING","Basking Ridge","New Jersey","07920","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-74.54932,40.70621,{"lat":53,"lon":52},[56],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"facility":58,"status":43,"city":59,"state":45,"zip":60,"country":47,"countryCode":48,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Memorial Sloan Kettering Monmouth (Limited Protocol Activities)","Middletown","07748",{"type":50,"coordinates":62},[63,64],-74.11709,40.39428,{"lat":64,"lon":63},[67],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"facility":69,"status":43,"city":70,"state":71,"zip":72,"country":47,"countryCode":48,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Memorial Sloan Kettering Commack (Limited Protocol Activities)","Commack","New York","11725",{"type":50,"coordinates":74},[75,76],-73.29289,40.84288,{"lat":76,"lon":75},[79],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"facility":81,"status":43,"city":70,"state":71,"zip":72,"country":47,"countryCode":48,"cosmosGeoPoint":82,"geoPoint":84,"contacts":85},"Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)",{"type":50,"coordinates":83},[75,76],{"lat":76,"lon":75},[86],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"facility":88,"status":43,"city":89,"state":71,"zip":90,"country":47,"countryCode":48,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Memorial Sloan Kettering West Harrison (Limited Protocol Activities)","Harrison","10604",{"type":50,"coordinates":92},[93,94],-73.71263,40.96899,{"lat":94,"lon":93},[97],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"facility":99,"status":43,"city":71,"state":71,"zip":100,"country":47,"countryCode":48,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Memorial Sloan Kettering Cancer Center (All Protocol Activities)","10065",{"type":50,"coordinates":102},[103,104],-74.00597,40.71427,{"lat":104,"lon":103},[107],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"facility":109,"status":43,"city":110,"state":71,"zip":111,"country":47,"countryCode":48,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Memorial Sloan Kettering Nassau (Limited Protocol Activities)","Uniondale","11553",{"type":50,"coordinates":113},[114,115],-73.59291,40.70038,{"lat":115,"lon":114},[118],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":35},{"type":120,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR",[122],{"name":123,"class":124},"Amgen","INDUSTRY","100578155","phase-1-a-study-of-sotorasib-in-people-with-brain-tumors-100578155",false,"NCT06807619","A Study of Sotorasib in People With Brain Tumors","BrainMet ADePPT (Anticancer Drug Penetration Platform Trial)","Inclusion Criteria:\n\n* Adult patients ≥ 18 years of age with one or more brain tumors planned for neurosurgical resection\u002Fbiopsy\n* Patients with concomitant leptomeningeal metastasis are eligible provided they have parenchymal brain neoplastic disease requiring resection\u002Fbiopsy\n* For all cohorts: no limit on prior CNS radiation or systemic therapyKPS ≥ 60\n* Life expectancy \\>12 weeks\n* Adequate treatment washout period from prior therapies to allow recovery from any prior treatment-related toxicities before enrollment in the judgment of the Investigator\n* Adequate bone marrow, renal, hepatic, and coagulation parameters (obtained ≤7 days prior to the first day of study treatment):\n\n  * Absolute neutrophil count (ANC) ≥1.0 × 10\\^3\u002FμL (granulocyte-colony stimulating factor administration is not allowed within 1 week prior to C1D1)\n  * Platelet count ≥10.0x10\\^4\u002FμL. Note: Participants requiring ongoing transfusions or growth factor support to maintain platelet count ≥10.0x10\\^4\u002FμL are not eligible. (Platelet transfusion is not allowed within 1 week prior to C1D1)\n  * Hemoglobin ≥ 7.0 g\u002FdL (≥ 8 g\u002FdL in gastric cancer \u002F gastroesophageal cancer indications). Note: Participants requiring ongoing transfusions or growth factor support to maintain hemoglobin ≥8.0 g\u002FdL are not eligible (Red blood cell transfusion is not allowed within 1 week prior to C1D1)\n  * Creatinine clearance ≥30 mL\u002Fmin, as calculated using the Cockcroft-Gault equation\n  * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤3 × upper limit of normal (ULN) (\\\u003C5x ULN in participants with liver metastases)\n  * Total bilirubin ≤1.5 × ULN) if no liver metastases or \\\u003C3 × ULN in the presence of documented Gilbert's syndrome (unconjugated hyperbilirubinemia) or liver metastases at baseline\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to study treatment or any of the study drug excipients. For patients who are allergic to gadolinium-based agents may receive premedication as per institutional protocol or imaged without contrast at the discretion of the Principal Investigator; reactions will be managed per standard institutional protocol\n* Multiple primary malignancies within 3 years, with the exception of:\n\n  * adequately resected non-melanoma skin cancer\n  * carcinoma in situ of the cervix\n  * Smoldering pre-malignant or malignant conditions with minimal concern for CNS or extracranial progression during treatment such as CLL or MGUS based on the assessment of the treating provider\n  * curatively treated in-situ disease\n  * other solid tumors curatively treated\n  * for patients with metastatic breast cancer: contralateral breast cancer","ALL","18 Years",{"count":135,"type":136},16,"ESTIMATED","INTERVENTIONAL",[139],"PHASE1","The researchers are doing this study to find out how effective sotorasib is at getting into KRAS G12C+ brain tumors. The researchers will also find out whether sotorasib is a safe and effective treatment for people undergoing surgical resection of KRAS G12C+ metastatic brain tumors, and do tests that show how the body absorbs, distributes, and gets rid of sotorasib.",[142],"Brain Tumor",[144,145,146,147,148],"SOTORASIB","KRAS G12C","CNS-BRAIN","Advanced","24-111","2026-05-21",{"date":151,"type":152},"2026-05-22","ACTUAL",{"date":154,"type":152},"2025-01-29",{"date":156,"type":136},"2028-01",{"name":5,"class":6},7]