[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640375":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":11,"responsibleParty":25,"collaborators":11,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":11,"eligibilityCriteria":33,"healthyVolunteers":29,"sex":34,"minAge":35,"maxAge":11,"enrollmentInfo":36,"targetDuration":11,"studyType":39,"phases":40,"briefSummary":42,"conditions":43,"keywords":11,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":11},{"fullName":5,"class":6},"CSPC Megalith Biopharmaceutical Co.,Ltd.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"SYS6051","EXPERIMENTAL",null,[13],"Drug: SYS6051",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":11},"DRUG","SYS6051 is administered by intravenous infusion every 3 weeks (Q3W). The doses administered for the first and subsequent visits of SYS6051 will be calculated based on the weight at screening\u002Fbaseline and prior to dosing at subsequent visits.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},"Clinical Trials Information Group","CONTACT","86-0311-69085587","ctr-contact@cspc.cn",{"type":26,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100640375","phase-1-a-study-of-sys6051-in-subjects-with-advanced-solid-tumors-100640375",false,"NCT07591285","A Study of SYS6051 in Subjects With Advanced Solid Tumors","A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of SYS6051 in Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n1. Fully understand the clinical study and voluntarily sign the written ICF;\n2. Age ≥ 18 years;\n3. Have at least one measurable lesion according to RECIST 1.1;\n4. ECOG performance status score of 0 to 1;\n5. Have adequate organ function;\n6. Expected survival of at least 3 months;\n7. Eligible participants of childbearing potential must agree to use a reliable method of contraception with their partner during the study and for at least 4 months (males) or 7 months (females) after the last dose. Female participants of childbearing potential must have a negative blood pregnancy test within 7 days prior to the first dose;\n8. Histologically or cytologically confirmed diagnosis of advanced solid tumors. -\n\nExclusion Criteria:\n\n1\\. Presence of high bleeding risk factors; 2. Presence of active ocular disease; 3. Patients with other active malignant tumors; 4. Uncontrolled serous effusions requiring frequent drainage or medical intervention within 14 days prior to the first dose; 5. Serious chronic or active infection; 6. Surgical on vital organs within 4 weeks prior to the first dose or planned systemic or local tumor resection during the study; 7. Untreated (including baseline findings) or unstable parenchymal metastases, spinal cord metastases or compression, carcinomatous meningitis; 8. History of non-infectious lung disease\u002Fpneumonitis requiring steroid hormone therapy or current interstitial lung disease\u002Fpneumonitis or suspected by imaging during screening; 9. History of significant cardiovascular disease; 10. History of immunodeficiency, Active hepatitis B or hepatitis C; 11. Known serious allergic reactions to the study drug or other ingredients and excipients in the formulation; 12. Pregnant or lactating women; 13. Presence of other conditions that could interfere with the participant 's participation in study procedures or would not be in the best interest of the participant' s participation in the study or affect the study results: such as a history of mental illness, drug use, or drug abuse, any other clinically significant disease or condition.\n\n\\-","ALL","18 Years",{"count":37,"type":38},114,"ESTIMATED","INTERVENTIONAL",[41],"PHASE1","This is a multicenter, open-label, dose-escalation and backfill, and cohort-expansion phase I clinical study to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor efficacy of SYS6051 in participants with advanced solid tumors.",[44],"Advanced Solid Tumors","NOT_YET_RECRUITING","2026-05-09",{"date":48,"type":49},"2026-05-15","ACTUAL",{"date":51,"type":38},"2026-05-12",{"date":53,"type":38},"2028-06-30",{"name":5,"class":6}]