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Subjects who have been cured of other tumors by local therapy, such as basal cell carcinoma, squamous cell carcinoma of skin, bladder cancer in situ, cervical carcinoma in situ, or breast cancer in situ, are not excluded.\n2. Patients with brainstem metastases, leptomeningeal metastases, spinal cord metastases, or spinal cord compression.\n3. Patients with severe, uncontrolled cardiovascular disease.\n4. Patients with concomitant pulmonary disease resulting in clinically severe impairment of respiratory function.\n5. History of interstitial lung disease (ILD) or non-infectious pneumonitis requiring corticosteroid therapy, OR current ILD or non-infectious pneumonitis.\n6. Prior treatment with a B7-H3 targeted therapy (including antibodies, antibody-drug conjugates \\[ADCs\\], CAR-T cells, and other agents), or with a topoisomerase I inhibitor or an ADC containing a topoisomerase I inhibitor payload.\n7. 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