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275598","Heidelberg","Baden-Wurttemberg","69120","Germany","DE",{"type":68,"coordinates":291},[292,293],8.69079,49.40768,{"lat":293,"lon":292},{"facility":296,"status":61,"city":297,"state":298,"zip":299,"country":288,"countryCode":289,"cosmosGeoPoint":300,"geoPoint":304,"contacts":36},"Klinikum der Universitaet Muenchen Grosshadern \u002FID# 276658","Munich","Bavaria","81337",{"type":68,"coordinates":301},[302,303],11.57549,48.13743,{"lat":303,"lon":302},{"facility":306,"status":61,"city":307,"state":298,"zip":308,"country":288,"countryCode":289,"cosmosGeoPoint":309,"geoPoint":313,"contacts":36},"Universitaetsklinikum Wuerzburg \u002FID# 276657","Würzburg","97080",{"type":68,"coordinates":310},[311,312],9.95121,49.79391,{"lat":312,"lon":311},{"facility":315,"status":61,"city":316,"state":36,"zip":317,"country":288,"countryCode":289,"cosmosGeoPoint":318,"geoPoint":322,"contacts":36},"Universitaetsklinikum Hamburg-Eppendorf \u002FID# 275803","Hamburg","20246",{"type":68,"coordinates":319},[320,321],9.99302,53.55073,{"lat":321,"lon":320},{"facility":324,"status":61,"city":325,"state":326,"zip":327,"country":328,"countryCode":329,"cosmosGeoPoint":330,"geoPoint":334,"contacts":36},"Rabin Medical Center. \u002FID# 272073","Petah Tikva","Central District","4941492","Israel","IL",{"type":68,"coordinates":331},[332,333],34.88747,32.08707,{"lat":333,"lon":332},{"facility":336,"status":61,"city":337,"state":338,"zip":339,"country":328,"countryCode":329,"cosmosGeoPoint":340,"geoPoint":344,"contacts":36},"The Chaim Sheba Medical Center \u002FID# 271251","Ramat Gan","Tel Aviv","5265601",{"type":68,"coordinates":341},[342,343],34.81065,32.08227,{"lat":343,"lon":342},{"facility":346,"status":61,"city":338,"state":338,"zip":347,"country":328,"countryCode":329,"cosmosGeoPoint":348,"geoPoint":352,"contacts":36},"Tel Aviv Sourasky Medical Center \u002FID# 271252","6423906",{"type":68,"coordinates":349},[350,351],34.78057,32.08088,{"lat":351,"lon":350},{"facility":354,"status":61,"city":355,"state":36,"zip":356,"country":328,"countryCode":329,"cosmosGeoPoint":357,"geoPoint":361,"contacts":36},"Rambam Health Care Campus- Haifa \u002FID# 271256","Haifa","3109601",{"type":68,"coordinates":358},[359,360],34.99928,32.81303,{"lat":360,"lon":359},{"facility":363,"status":61,"city":364,"state":36,"zip":365,"country":328,"countryCode":329,"cosmosGeoPoint":366,"geoPoint":370,"contacts":36},"Hadassah Medical Center-Hebrew University \u002FID# 271253","Jerusalem","91120",{"type":68,"coordinates":367},[368,369],35.21633,31.76904,{"lat":369,"lon":368},{"facility":372,"status":61,"city":373,"state":36,"zip":374,"country":375,"countryCode":376,"cosmosGeoPoint":377,"geoPoint":381,"contacts":36},"Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico \u002FID# 276306","Milan","20122","Italy","IT",{"type":68,"coordinates":378},[379,380],12.59836,42.78235,{"lat":380,"lon":379},{"facility":383,"status":61,"city":384,"state":385,"zip":386,"country":387,"countryCode":388,"cosmosGeoPoint":389,"geoPoint":393,"contacts":36},"Nagoya City University Hospital \u002FID# 271427","Nagoya","Aichi-ken","467-8602","Japan","JP",{"type":68,"coordinates":390},[391,392],136.90641,35.18147,{"lat":392,"lon":391},{"facility":395,"status":61,"city":396,"state":396,"zip":397,"country":387,"countryCode":388,"cosmosGeoPoint":398,"geoPoint":402,"contacts":36},"University Hospital Kyoto Prefectural University of Medicine \u002FID# 271911","Kyoto","602-8566",{"type":68,"coordinates":399},[400,401],135.75385,35.02107,{"lat":401,"lon":400},{"facility":404,"status":61,"city":405,"state":406,"zip":407,"country":387,"countryCode":388,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"The University of Osaka Hospital \u002FID# 271636","Suita-shi","Osaka","565-0871",{"facility":409,"status":61,"city":410,"state":411,"zip":412,"country":387,"countryCode":388,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Japanese Red Cross Medical Center \u002FID# 272018","Shibuya-ku","Tokyo","150-8935",{"facility":414,"status":61,"city":411,"state":36,"zip":415,"country":387,"countryCode":388,"cosmosGeoPoint":416,"geoPoint":420,"contacts":36},"The Jikei University Hospital \u002FID# 272091","105-8461",{"type":68,"coordinates":417},[418,419],139.69171,35.6895,{"lat":419,"lon":418},{"facility":422,"status":61,"city":423,"state":424,"zip":425,"country":426,"countryCode":427,"cosmosGeoPoint":428,"geoPoint":432,"contacts":36},"Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie \u002FID# 276052","Lublin","Lublin Voivodeship","20-081","Poland","PL",{"type":68,"coordinates":429},[430,431],22.57009,51.25058,{"lat":431,"lon":430},{"facility":434,"status":61,"city":423,"state":424,"zip":435,"country":426,"countryCode":427,"cosmosGeoPoint":436,"geoPoint":438,"contacts":36},"Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie \u002FID# 276352","20-090",{"type":68,"coordinates":437},[430,431],{"lat":431,"lon":430},{"facility":440,"status":61,"city":441,"state":442,"zip":443,"country":426,"countryCode":427,"cosmosGeoPoint":444,"geoPoint":448,"contacts":36},"Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada \u002FID# 276263","Warsaw","Masovian Voivodeship","02-781",{"type":68,"coordinates":445},[446,447],21.01178,52.22977,{"lat":447,"lon":446},{"facility":450,"status":61,"city":451,"state":452,"zip":453,"country":454,"countryCode":455,"cosmosGeoPoint":456,"geoPoint":460,"contacts":36},"Instituto Portugues de Oncologia de Lisboa Francisco Gentil \u002FID# 275873","Lisbon","Lisbon District","1099-023","Portugal","PT",{"type":68,"coordinates":457},[458,459],-9.1498,38.72509,{"lat":459,"lon":458},{"facility":462,"status":61,"city":463,"state":36,"zip":464,"country":454,"countryCode":455,"cosmosGeoPoint":465,"geoPoint":469,"contacts":36},"Unidade Local de Saude de Braga, EPE \u002FID# 275853","Braga","4710-243",{"type":68,"coordinates":466},[467,468],-8.42311,41.5514,{"lat":468,"lon":467},{"facility":471,"status":61,"city":472,"state":36,"zip":473,"country":454,"countryCode":455,"cosmosGeoPoint":474,"geoPoint":478,"contacts":36},"Instituto Portugues de Oncologia do Porto Francisco Gentil \u002FID# 275851","Porto","4200-072",{"type":68,"coordinates":475},[476,477],-8.61097,41.1485,{"lat":477,"lon":476},{"facility":480,"status":61,"city":481,"state":482,"zip":483,"country":484,"countryCode":485,"cosmosGeoPoint":486,"geoPoint":490,"contacts":36},"Karolinska University Hospital Solna \u002FID# 271674","Solna","Stockholm County","171 64","Sweden","SE",{"type":68,"coordinates":487},[488,489],18.00086,59.36004,{"lat":489,"lon":488},{"facility":492,"status":61,"city":493,"state":494,"zip":495,"country":484,"countryCode":485,"cosmosGeoPoint":496,"geoPoint":500,"contacts":36},"Sodra Alvsborgs sjukhus \u002FID# 271822","Borås","Västra Götaland County","501 82",{"type":68,"coordinates":497},[498,499],12.9401,57.72101,{"lat":499,"lon":498},{"facility":502,"status":61,"city":503,"state":494,"zip":504,"country":484,"countryCode":485,"cosmosGeoPoint":505,"geoPoint":509,"contacts":36},"Sahlgrenska Universitetssjukhuset \u002FID# 272448","Gothenburg","413 46",{"type":68,"coordinates":506},[507,508],11.96679,57.70716,{"lat":508,"lon":507},{"facility":511,"status":61,"city":512,"state":36,"zip":513,"country":514,"countryCode":515,"cosmosGeoPoint":516,"geoPoint":520,"contacts":36},"The Christie NHS Foundation Trust - Christie Hospital \u002FID# 276276","Manchester","M20 4BX","United Kingdom","UK",{"type":68,"coordinates":517},[518,519],-2.23743,53.48095,{"lat":519,"lon":518},{"type":522,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100589403","phase-1-a-study-to-assess-adverse-events-and-change-in-disease-activity-of-oral-surzetoclax-alone-or-in-combination-with-subcutaneous-andor-oral-antimyeloma-agents-in-adult-participants-with-multiple-myeloma-mm-100589403",false,"NCT06953960","A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and\u002For Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)","A Phase 1\u002F2, Open-Label, Platform Study to Evaluate Safety and Efficacy of the BCL-2 Inhibitor Surzetoclax (ABBV-453) Given as Monotherapy or in Combination With Antimyeloma Regimens in Subjects With Multiple Myeloma","Inclusion Criteria:\n\n* Documented diagnosis of multiple myeloma (MM) based on standard international myeloma working group (IMWG) diagnostic criteria.\n* All participants must have measurable disease per central laboratory with at least 1 of the following assessed within 28 days prior to enrollment:\n\n  * Serum M-protein \\>= 0.5 g\u002FdL (\\>= 5g\u002FL); OR\n  * Urine M-protein \\>= 200 mg\u002F24 hours; OR\n  * For participants without measurable serum and urine M-protein: Serum free light chain (sFLC) ≥ 10 mg\u002FdL (100 mg\u002FL), provided sFLC ratio is abnormal.\n* B-cell lymphoma (BCL)-2 inhibitor treatment naïve.\n* t(11;14) positive status and\u002For BCL2 high status.\n* Substudy 1 Dose Escalation Cohorts and Substudy 2:\n\n  \\-- Must be triple class exposed (PI, IMiD and anti-CD38) and have received 3 to 5 lines of prior antimyeloma therapy, and who have no other appropriate treatment options as deemed by the investigator.\n* Substudy 1 Dose Expansion Cohorts:\n\n  * Must be double class exposed (PI, IMiD) and have received 1 to 3 lines of prior antimyeloma therapy.\n\nExclusion Criteria:\n\n* Major surgery within 4 weeks of study treatment or planned during study participation.\n* Active infections: no recent infection requiring systemic treatment that was completed \\\u003C= 7 days before first dose of study treatment and\u002For uncontrolled systemic infection.\n* Recent infection requiring systemic treatment that was completed \\\u003C= 7 days before first dose of study treatment and\u002For uncontrolled active systemic infection.","ALL","18 Years",{"count":533,"type":534},199,"ESTIMATED","INTERVENTIONAL",[537,538],"PHASE1","PHASE2","Multiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the safety and change in disease activity of surzetoclax in adult participants with relapsed\u002Frefractory (R\u002FR) MM. Adverse events and change in disease activity will be assessed.\n\nSurzetoclax is an investigational drug being developed for the treatment of R\u002FR MM. In Substudy 1 there will be a dose escalation phase where participants will receive various doses of surzetoclax in combination with daratumumab + dexamethasone, to determine the best dose of surzetoclax. This will be followed by a dose expansion and selection phase where participants will receive 1 of 2 doses of surzetoclax in combination with daratumumab + dexamethasone, or daratumumab + dexamethasone + pomalidomide (only during the expansion phase). In Substudy 2, there will be a dose escalation phase where participants will receive various doses of surzetoclax alone. Approximately 130 adult participants with R\u002FR MM will be enrolled in the study in approximately 40 sites worldwide.\n\nIn Substudy 1 escalation phase, participants will receive oral surzetoclax tablets in combination with subcutaneous (SC) daratumumab injections + oral dexamethasone tablets and in the expansion phase, will receive oral surzetoclax tablets in combination with SC daratumumab injections + oral dexamethasone tablets or daratumumab injections + oral pomalidomide + oral dexamethasone tablets. In Substudy 2, Japanese participants will receive oral surzetoclax tablets. The total study duration is approximately 4.5 years.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution. The effect of the treatment will be frequently checked by medical assessments, blood tests, and side effects.",[541],"Multiple Myeloma",[541,33,543,38,42,45,544],"Surzetoclax","Cancer","2026-06-22",{"date":547,"type":548},"2026-06-24","ACTUAL",{"date":550,"type":548},"2025-07-23",{"date":552,"type":534},"2030-12",{"name":5,"class":6},47]