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The study consists of 2 phases: Phase Ib and Phase II. Phase Ib will evaluate the safety and pharmacokinetics (PK) of GDC-4198 alone and in combination with giredestrant. Phase II stage will compare the activity and safety of GDC-4198 and giredestrant with abemaciclib and giredestrant.",[578],"Breast Cancer","2026-07-10",{"date":581,"type":582},"2026-07-13","ACTUAL",{"date":584,"type":582},"2025-10-07",{"date":586,"type":571},"2028-08-31",{"name":5,"class":6},52]