[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568558":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":28,"centralContacts":33,"locations":39,"responsibleParty":204,"collaborators":27,"id":206,"slug":207,"hasResults":208,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":208,"sex":214,"minAge":215,"maxAge":27,"enrollmentInfo":216,"targetDuration":27,"studyType":219,"phases":220,"briefSummary":223,"conditions":224,"keywords":242,"overallStatus":42,"whyStopped":27,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":268},{"fullName":5,"class":6},"A2 Biotherapeutics Inc.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"A2B395","EXPERIMENTAL","Participants receive preconditioning lymphodepletion (PCLD) regimen followed by a single dose of A2B395 intravenously on day 0",[13,14],"Biological: A2B395","Diagnostic Test: xT CDx with HLA-LOH assay",[16,22],{"type":17,"name":9,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","Allogeneic logic-gated Tmod CAR T cells",[9],[21],"Tmod CAR T-cell Therapy",{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIAGNOSTIC_TEST","xT CDx with HLA-LOH assay","An investigational next generation sequencing (NGS) in vitro diagnostic (IVD) medical device",[9],null,[29],{"name":30,"affiliation":31,"role":32},"John Welch, MD, PhD","A2 Biotherapeutics","STUDY_DIRECTOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":27,"email":38},"Clinical Trials","CONTACT","310-431-9180","ClinicalTrials@a2bio.com",[40,61,80,95,111,126,139,155,172,188],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Banner MD Anderson Cancer Center","RECRUITING","Gilbert","Arizona","85234","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-111.78903,33.35283,{"lat":52,"lon":51},[55,58],{"name":56,"role":36,"phone":27,"phoneExt":27,"email":57},"Kylie Ketchum","kylie.ketchum@bannerhealth.com",{"name":59,"role":60,"phone":27,"phoneExt":27,"email":27},"Matthew Ulrickson, MD","PRINCIPAL_INVESTIGATOR",{"facility":62,"status":42,"city":63,"state":64,"zip":65,"country":46,"countryCode":47,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"UCSD Moores Cancer Center","La Jolla","California","92093",{"type":49,"coordinates":67},[68,69],-117.2742,32.84727,{"lat":69,"lon":68},[72,75,78],{"name":73,"role":36,"phone":27,"phoneExt":27,"email":74},"Jona Plevin","jplevin@health.ucsd.edu",{"name":76,"role":36,"phone":27,"phoneExt":27,"email":77},"Rebecca Shatsky","rshatshy@health.ucsd.edu",{"name":79,"role":60,"phone":27,"phoneExt":27,"email":27},"Rebecca Shatsky, MD",{"facility":81,"status":42,"city":82,"state":64,"zip":83,"country":46,"countryCode":47,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"UCLA Medical Center","Los Angeles","90404",{"type":49,"coordinates":85},[86,87],-118.24368,34.05223,{"lat":87,"lon":86},[90,93],{"name":91,"role":36,"phone":27,"phoneExt":27,"email":92},"Lisa Del Rio","ldelrio@mednet.ucla.edu",{"name":94,"role":60,"phone":27,"phoneExt":27,"email":27},"Deborah Wong, MD",{"facility":96,"status":42,"city":97,"state":98,"zip":99,"country":46,"countryCode":47,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Mayo Clinic","Jacksonville","Florida","32224",{"type":49,"coordinates":101},[102,103],-81.65565,30.33218,{"lat":103,"lon":102},[106,109],{"name":107,"role":36,"phone":108,"phoneExt":27,"email":27},"Clinical Trials Referral Office","855-776-0015",{"name":110,"role":60,"phone":27,"phoneExt":27,"email":27},"Yanyan Lou, MD",{"facility":112,"status":42,"city":113,"state":98,"zip":114,"country":46,"countryCode":47,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Moffitt Cancer Center","Tampa","33606",{"type":49,"coordinates":116},[117,118],-82.45843,27.94752,{"lat":118,"lon":117},[121,124],{"name":122,"role":36,"phone":27,"phoneExt":27,"email":123},"Gillian Zankel","Gillian.Zankel@moffitt.org",{"name":125,"role":60,"phone":27,"phoneExt":27,"email":27},"Kedar Kirtane, MD",{"facility":96,"status":42,"city":127,"state":128,"zip":129,"country":46,"countryCode":47,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Rochester","Minnesota","55905",{"type":49,"coordinates":131},[132,133],-92.4699,44.02163,{"lat":133,"lon":132},[136,137],{"name":107,"role":36,"phone":108,"phoneExt":27,"email":27},{"name":138,"role":60,"phone":27,"phoneExt":27,"email":27},"Harry E. Fuentes Bayne, MD",{"facility":140,"status":42,"city":141,"state":142,"zip":143,"country":46,"countryCode":47,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Washington University","St Louis","Missouri","63110",{"type":49,"coordinates":145},[146,147],-90.19789,38.62727,{"lat":147,"lon":146},[150,153],{"name":151,"role":36,"phone":27,"phoneExt":27,"email":152},"Amberly Scott","amberly@wustl.edu",{"name":154,"role":60,"phone":27,"phoneExt":27,"email":27},"Patrick Grierson, M.D., Ph.D.",{"facility":156,"status":42,"city":157,"state":157,"zip":158,"country":46,"countryCode":47,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"NYU Langone Health","New York","10016",{"type":49,"coordinates":160},[161,162],-74.00597,40.71427,{"lat":162,"lon":161},[165,168,171],{"name":166,"role":36,"phone":27,"phoneExt":27,"email":167},"# Phase1Screening","#phase1screening@nyulangone.org",{"name":169,"role":36,"phone":27,"phoneExt":27,"email":170},"Salman Punekar, MD","Salman.punekar@nyulangone.org",{"name":169,"role":60,"phone":27,"phoneExt":27,"email":27},{"facility":173,"status":42,"city":174,"state":175,"zip":176,"country":46,"countryCode":47,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"The Ohio State University","Columbus","Ohio","43210",{"type":49,"coordinates":178},[179,180],-82.99879,39.96118,{"lat":180,"lon":179},[183,186],{"name":184,"role":36,"phone":27,"phoneExt":27,"email":185},"Cindi Jenkins","Cynthia.Jenkins@osumc.edu",{"name":187,"role":60,"phone":27,"phoneExt":27,"email":27},"Kai He, MD, PhD",{"facility":189,"status":42,"city":190,"state":191,"zip":192,"country":46,"countryCode":47,"cosmosGeoPoint":193,"geoPoint":197,"contacts":198},"Fred Hutch Cancer Center","Seattle","Washington","98109",{"type":49,"coordinates":194},[195,196],-122.33207,47.60621,{"lat":196,"lon":195},[199,202],{"name":200,"role":36,"phone":27,"phoneExt":27,"email":201},"Shelby Colden","scolden2@fredhutch.org",{"name":203,"role":60,"phone":27,"phoneExt":27,"email":27},"Jennifer Specht, MD",{"type":205,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100568558","phase-1-a-study-to-evaluate-the-safety-and-efficacy-of-a2b395-an-allogeneic-logic-gated-car-t-in-participants-with-solid-tumors-that-express-egfr-and-have-lost-hla-a02-expression-100568558",false,"NCT06682793","A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression","A Seamless Phase 1\u002F2 Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated Tmod™ CAR T, in Heterozygous HLA-A*02 Adults With Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression","DENALI-1","Inclusion Criteria:\n\nKey Inclusion Criteria:\n\n1. Appropriately enrolled in the BASECAMP-1 A2 Biotherapeutics, Inc. study, with tissue demonstrating LOH of HLA-A\\*02 by NGS (whenever possible from the primary site).\n2. Histologically confirmed recurrent unresectable, locally advanced, or metastatic CRC, NSCLC, HNSCC, TNBC, RCC, or other solid tumors with EGFR expression. Measurable disease is required with lesions of ≥1.0 cm by CT.\n3. Received previous required therapy for the appropriate solid tumor disease as described in the protocol\n4. Has adequate organ function as described in the protocol\n5. ECOG performance status of 0 to 1\n6. Life expectancy of ≥3 months\n7. Willing to comply with study schedule of assessments including long-term safety follow-up\n\nKey Exclusion Criteria:\n\n1. Has disease that is suitable for local therapy or able to receive standard of care therapy that is therapeutic and not palliative\n2. Prior allogeneic stem cell transplant\n3. Prior solid organ transplant\n4. Cancer therapy within 3 weeks or 3 half lives of A2B395 infusion\n5. Radiotherapy within 28 days of A2B395 infusion\n6. Unstable angina, arrhythmia, myocardial infarction, or any other significant cardiac disease within the last 6 months\n7. Any new symptomatic pulmonary embolism (PE) or a deep vein thrombosis (DVT) within 3 months of enrollment. Therapeutic dosing of anticoagulants is allowed for history of PE or DVT if greater than 3 months from time of enrollment, and adequately treated\n8. History of interstitial lung disease including drug-induced interstitial lung disease and radiation pneumonitis that requires treatment with prolonged steroids or other immune suppressive agents within 1 year\n9. Requires supplemental home oxygen\n10. Females of childbearing potential who are pregnant or breastfeeding\n11. Subjects, both male and female, of childbearing potential who are not willing to practice birth control from the time of consent through 6 months post infusion of A2B395","ALL","18 Years",{"count":217,"type":218},240,"ESTIMATED","INTERVENTIONAL",[221,222],"PHASE1","PHASE2","The goal of this study is to test A2B395, an allogeneic logic-gated Tmod™ CAR T-cell product in subjects with solid tumors including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), triple-negative breast cancer (TNBC), renal cell carcinoma (RCC) and other solid tumors that express EGFR and have lost HLA-A\\*02 expression.\n\nThe main questions this study aims to answer are:\n\n* Phase 1: What is the recommended dose of A2B395 that is safe for patients\n* Phase 2: Does the recommended dose of A2B395 kill the solid tumor cells and protect the patient's healthy cells\n\nParticipants will be required to perform study procedures and assessments, and will also receive the following study treatments:\n\n* Enrollment in BASECAMP-1 (NCT04981119)\n* Preconditioning lymphodepletion (PCLD) regimen\n* A2B395 Tmod CAR T cells at the assigned dose",[225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241],"Solid Tumor, Adult","Colorectal Cancer","Non-Small Cell Lung","NSCLC (Non-small Cell Lung Cancer)","Cancer","Colon Cancer","Rectal Cancer","Lung Cancer","CRC","Head and Neck Squamous Cell Cancer","HNSCC","Renal Cell Carcinoma","RCC","Kidney Cancer","Triple Negative Breast Cancer","TNBC","Colorectal Adenocarcinoma",[243,244,245,246,247,248,249,233,250,251,252,253,229,254,255,232,256,237,238,257,258,240],"CAR T Cell","Solid Tumors","Allogeneic","T Cell","EGFR","HLA-A2","Solid tumors expressing EGFR","Colorectal","Cell Therapy","Gene Therapy","Blocker","NSCLC","Non small Cell Lung Cancer","renal cell carcinoma","Renal cell cancer","Triple negative breast cancer","2025-09-03",{"date":261,"type":262},"2025-09-09","ACTUAL",{"date":264,"type":262},"2025-05-22",{"date":266,"type":218},"2030-03-31",{"name":5,"class":6},10]