[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606163":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":38,"locations":46,"responsibleParty":165,"collaborators":11,"id":167,"slug":168,"hasResults":169,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":11,"eligibilityCriteria":173,"healthyVolunteers":169,"sex":174,"minAge":175,"maxAge":176,"enrollmentInfo":177,"targetDuration":11,"studyType":180,"phases":181,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":49,"whyStopped":11,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":200},{"fullName":5,"class":6},"Bristol-Myers Squibb","INDUSTRY",[8,14,19,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Part A: Administration of BMS-986454","EXPERIMENTAL",null,[13],"Drug: BMS-986454",{"label":15,"type":16,"description":11,"interventionNames":17},"Part A: Placebo","PLACEBO_COMPARATOR",[18],"Other: Placebo",{"label":20,"type":10,"description":11,"interventionNames":21},"Part B: Administration of BMS-986454",[13],{"label":23,"type":16,"description":11,"interventionNames":24},"Part B: Placebo",[18],[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"DRUG","BMS-986454","Specified dose on specified days",[9,20],{"type":32,"name":33,"description":29,"armGroupLabels":34,"otherNames":11},"OTHER","Placebo",[15,23],[36],{"name":5,"affiliation":5,"role":37},"STUDY_DIRECTOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":11,"email":43},"BMS Clinical Trials Contact Center www.BMSClinicalTrials.com","CONTACT","855-907-3286","Clinical.Trials@bms.com",{"name":45,"role":41,"phone":11,"phoneExt":11,"email":11},"First line of the email MUST contain NCT # and Site #.",[47,59,74,87,99,113,126,140,152],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":11,"geoPoint":11,"contacts":55},"Nizams Institute Of Medical Sciences","RECRUITING","Hyderabad","Andhra Pradesh","500 082","India","IN",[56],{"name":57,"role":41,"phone":58,"phoneExt":11,"email":11},"Liza Rajasekhar, Site 0006","9391008618",{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":53,"countryCode":54,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Local Institution - 0004","NOT_YET_RECRUITING","Ahmedabad","Gujarat","382428",{"type":66,"coordinates":67},"Point",[68,69],72.58727,23.02579,{"lat":69,"lon":68},[72],{"name":73,"role":41,"phone":11,"phoneExt":11,"email":11},"Site 0004",{"facility":75,"status":61,"city":76,"state":77,"zip":78,"country":53,"countryCode":54,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Local Institution - 0003","Bangalore","Karnataka","560 034",{"type":66,"coordinates":80},[81,82],77.59369,12.97194,{"lat":82,"lon":81},[85],{"name":86,"role":41,"phone":11,"phoneExt":11,"email":11},"Site 0003",{"facility":88,"status":61,"city":89,"state":77,"zip":90,"country":53,"countryCode":54,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Local Institution - 0009","Mysuru","5700004",{"type":66,"coordinates":92},[93,94],76.63925,12.29791,{"lat":94,"lon":93},[97],{"name":98,"role":41,"phone":11,"phoneExt":11,"email":11},"Site 0009",{"facility":100,"status":49,"city":101,"state":102,"zip":103,"country":53,"countryCode":54,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"All India Institute of Medical Sciences (AIIMS) - Nagpur","Nagpur","Maharashtra","441108",{"type":66,"coordinates":105},[106,107],79.08491,21.14631,{"lat":107,"lon":106},[110],{"name":111,"role":41,"phone":112,"phoneExt":11,"email":11},"Rajashree Khot, Site 0008","9823134598",{"facility":114,"status":49,"city":115,"state":102,"zip":116,"country":53,"countryCode":54,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Life Point Mutispecialty Hospital Pvt. Ltd.","Pune","411057",{"type":66,"coordinates":118},[119,120],73.85535,18.51957,{"lat":120,"lon":119},[123],{"name":124,"role":41,"phone":125,"phoneExt":11,"email":11},"Pathak Ameya Ramchandra, Site 0005","02066 434366\u002F434343",{"facility":127,"status":49,"city":128,"state":129,"zip":130,"country":53,"countryCode":54,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"Kalinga Institute of Medical Sciences- Bhubaneswar","Bhubaneswar","Odisha","751024",{"type":66,"coordinates":132},[133,134],85.83385,20.27241,{"lat":134,"lon":133},[137],{"name":138,"role":41,"phone":139,"phoneExt":11,"email":11},"Debashis Maikap, Site 0007","9040145062",{"facility":141,"status":61,"city":50,"state":142,"zip":143,"country":53,"countryCode":54,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Local Institution - 0002","Telangana","500004",{"type":66,"coordinates":145},[146,147],78.45636,17.38405,{"lat":147,"lon":146},[150],{"name":151,"role":41,"phone":11,"phoneExt":11,"email":11},"Site 0002",{"facility":153,"status":49,"city":154,"state":142,"zip":155,"country":53,"countryCode":54,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Krishna Institute of Medical Sciences Limited","Secunderabad","500003",{"type":66,"coordinates":157},[158,159],78.54263,17.50427,{"lat":159,"lon":158},[162],{"name":163,"role":41,"phone":164,"phoneExt":11,"email":11},"Sarath Veeravalli, Site 0001","9866000685",{"type":166,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100606163","phase-1-a-study-to-evaluate-the-safety-tolerability-and-drug-levels-of-bms-986454-in-participants-with-rheumatoid-arthritis-100606163",false,"NCT07171983","A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis","A 2-Part, Phase 1b Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986454 in Participants With Rheumatoid Arthritis","Inclusion Criteria:\n\n* Participants with Rheumatoid Arthritis must have onset after age 18.\n* Participants who meet 2010 American College of Rheumatology\u002FEuropean League Against Rheumatism (ACR\u002FEULAR) classification criteria for RA.\n* Participants must have evidence of swelling in at least 1 joint of the hand or wrist by clinical examination at screening and Day -1.\n* Participants must have been an incomplete responder to prior methotrexate (MTX) treatment.\n\nExclusion Criteria:\n\n* Participants must not have any significant medical condition, with the exception of Rheumatoid Arthritis (including but not limited to, neurological, GI, renal, hepatic, cardiovascular, psychological, pulmonary, metabolic, endocrine, hematological, allergic disease, drug allergies, or other major disorders) that, in the Investigator's judgment, will substantially increase the risk to the participant if he or she participates in the study.\n* Participants must not have any condition aside from RA that confounds the ability to interpret data from the study.\n* Participants must not have severe Rheumatoid Arthritis as assessed by Disease Activity Score 28 c-reactive protein (DAS28-CRP) at screening or Day -1.\n* Other protocol-defined Inclusion\u002FExclusion criteria apply.","ALL","18 Years","65 Years",{"count":178,"type":179},46,"ESTIMATED","INTERVENTIONAL",[182],"PHASE1","The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986454 in participants with Rheumatoid Arthritis",[185],"Rheumatoid Arthritis",[187,188,189,190],"Rheumatoid Arthritis (RA)","Autoimmune Disease","Chronic Inflammatory Disease","Methotrexate-Inadequate Responders (MTX-IR)","2026-06-05",{"date":193,"type":194},"2026-06-08","ACTUAL",{"date":196,"type":194},"2026-02-27",{"date":198,"type":179},"2027-08-25",{"name":5,"class":6},9]